Results 31 to 40 of about 57 (55)

ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction

Journal of Advanced Research
Introduction: N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A “eraser”, is responsible for decreased m6A modification.
Kun Yang, Yongchao Zhao, Jingjing Hu, Rifeng Gao, Jiaran Shi, Xiang Wei, Juntao Chen, Kai Hu, Aijun Sun, Junbo Ge   +9 more
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The dual mechanism of m6A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR

Cell Death and Disease
Exposure to MC-LR has been shown to cause multiple organ injury, particularly liver injury, and altered energy metabolism is closely linked. As an effective and efficient way to regulate biological gene expression, N(6)-methyladenosine(m6A) modification ...
Xiaoya Sun, Qinmei Tan, Yue Yang, Jia Wei, Xiaodie Zhou, Shanshan Gao, Fei Yang   +6 more
doaj   +1 more source

白N6-甲基腺苷修饰及其调控蛋在脑缺血中的表达变化及意义 Expression Changes and Significance of N6-Methyladenosine and its Regulatory Proteins in Cerebral Ischemia

Zhongguo cuzhong zazhi
目的 本研究通过探讨N6-甲基腺苷（N6-methyladenosine，m6A）修饰及其调控蛋白在脑缺血小鼠中的表达变化，为脑缺血治疗的分子靶点研究提供参考。 方法 取60只雄性C57BL/6J小鼠，随机分为假手术组、脑缺血1 d组、脑缺血3 d组和脑缺血7 d组，每组各15只，采用线栓法制作右侧大脑中动脉梗死模型，于缺血1 h进行拔栓再灌注。通过RNA提取及斑点印迹实验检测小鼠缺血侧脑组织RNA m6A水平；使用荧光定量逆转录PCR检测小鼠缺血侧脑组织甲基转移酶3 ...
叶维贞，赵顺英，姜鸣钰，黄秋茹，温少红，董雯，陈青芳，刘向荣(YE Weizhen, ZHAO Shunying, JIANG Mingyu, HUANG Qiuru, WEN Shaohong, DONG Wen, CHEN Qingfang, LIU Xiangrong)
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ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration

Cell & Bioscience
Background N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear.
Yu Lei, Enyu Zhan, Chao Chen, Yaoquan Hu, Zhengpin Lv, Qicong He, Xuenan Wang, Xingguo Li, Fan Zhang   +8 more
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Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression

Cellular & Molecular Biology Letters
Background The incidence of atherosclerosis markedly rises following menopause. Our previous findings demonstrated that elevated follicle-stimulating hormone (FSH) levels in postmenopausal women accelerate atherosclerosis progression. Plaque instability,
Ping Li, Yixiao Xiang, Jinzhi Wei, Xingyan Xu, Jiale Wang, Haowei Yu, Xiaosa Li, Huiping Lin, Xiaodong Fu   +8 more
doaj   +1 more source

ALKBH5 Promotes Breast Cancer Stemness Through Regulating Wnt/β-Catenin Signaling

Breast Cancer: Targets and Therapy
Kailin Wang,1,2 Kaiting Wang1 1Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology ...
Wang K, Wang K
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Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis

Frontiers in Physiology, 2022
Guohua Yuan, Huan Liu, Haojian Zhang
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The role of demethylase AlkB homologs in cancer

Frontiers in Oncology, 2023
Qingsan Zhu, Zhu Qingsan
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AlkB RNA demethylase homologues and N 6 ‐methyladenosine are involved in Potyvirus infection

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Mingmin Zhao, Fabio Pasin, Jian Ying Yue   +2 more
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Tanshinone IIA alleviates cardiac hypertrophy through m6A modification of galectin-3

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Weihua Wu
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