Results 11 to 20 of about 57 (55)

ALKBH5 inhibits TNF-α-induced apoptosis of HUVECs through Bcl-2 pathway

Open Medicine, 2022
The dysfunction and apoptosis of vascular endothelial cells are the initiating links in the formation of atherosclerosis. N6-methyladenosine (m6A) is an extremely extensive RNA methylation modification and its abnormality leads to the occurrence of ...
Zhang Xiaoshan, Deng ShiBing, Peng Yang, Wei Han, Tian Zhiming   +4 more
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RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner

Clinical and Translational Medicine, 2023
Background N6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) is a well‐described m6A demethylase in previous enzyme assays, we aimed to investigate the role of
Dingcheng Shen, Jinxin Lin, Yumo Xie, Zhuokai Zhuang, Gaopo Xu, Shaoyong Peng, Guannan Tang, Liangliang Bai, Mingxuan Zhu, Yu Zhang, Ziying Huang, Puning Wang, Xiaoxia Liu, Meijin Huang, Yanxin Luo, Xiaolin Wang, Huichuan Yu   +16 more
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5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis

Genome Medicine, 2021
Background tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues including blood and urine, play an important role in the progression of cancer. However, the expression of tDRs in colorectal cancer (CRC) plasma and their potential
Yingmin Wu, Xiangling Yang, Guanmin Jiang, Haisheng Zhang, Lichen Ge, Feng Chen, Jiexin Li, Huanliang Liu, Hongsheng Wang   +8 more
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m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration

Signal Transduction and Targeted Therapy, 2022
Neutrophil migration into the site of infection is necessary for antibacterial innate defense, whereas impaired neutrophil migration may result in excessive inflammation and even sepsis.
Yang Liu, Renjie Song, Lu Zhao, Zhike Lu, Yini Li, Xinyi Zhan, Fengjiao Lu, Jiang Yang, Yamei Niu, Xuetao Cao   +9 more
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ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1

Cellular & Molecular Biology Letters, 2022
Background N 6-methyladenosine (m6A) is the most common and abundant internal modification of RNA. Its critical functions in multiple physiological and pathological processes have been reported.
Wenqing Sun, Yan Li, Dongyu Ma, Yi Liu, Qi Xu, Demin Cheng, Guanru Li, Chunhui Ni   +7 more
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ALKBH5‐mediated m6A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma

Clinical and Translational Medicine, 2023
Background Radiation‐induced hepatic stellate cell (HSC) activation promotes radiation‐induced liver fibrosis (RILF), a complication for hepatocellular carcinoma (HCC) radiotherapy. The demethylase alpha‐ketoglutarate‐dependent dioxygenase alkB homolog 5
Yuhan Chen, Peitao Zhou, Yixun Deng, Xinni Cai, Mingrui Sun, Yining Sun, Dehua Wu   +6 more
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Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification

Journal of Animal Science and Biotechnology, 2019
Background N6-Methyladenosine (m6A), the most prevalent modification in mammalian mRNA, plays important roles in numerous biological processes. Several m6A associated proteins such as methyltransferase like 3 (METTL3), methyltransferase like 14 (METTL14),
Tao Huang, Jiayin Guo, Yinghua Lv, Yi Zheng, Tongying Feng, Qiang Gao, Wenxian Zeng   +6 more
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Progress of research on m6A demethylases in gastric cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban
Gastric cancer (GC) is one of the most common malignancies in the digestive system. Many patients are found in advanced stage and have a poor prognosis. Surgery and chemotherapy remain the main treatments for gastric cancer. N6-methyladenosine (m6A) is a
JIANG Shuang, YU Jiwei
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BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression

Acta Pharmaceutica Sinica B
The interaction between m6A-methylated RNA and chromatin modification remains largely unknown. We found that targeted inhibition of bromodomain-containing protein 4 (BRD4) by siRNA or its inhibitor (JQ1) significantly decreases mRNA m6A levels and ...
Haisheng Zhang, Linlin Lu, Cheng Yi, Tao Jiang, Yunqing Lu, Xianyuan Yang, Ke Zhong, Jiawang Zhou, Jiexin Li, Guoyou Xie, Zhuojia Chen, Zongpei Jiang, Gholamreza Asadikaram, Yanxi Peng, Dan Zhou, Hongsheng Wang   +15 more
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Complicated role of ALKBH5 in gastrointestinal cancer: an updated review

Cancer Cell International
Gastrointestinal cancer is the most common malignancy in humans, often accompanied by poor prognosis. N6-methyladenosine (m6A) modification is widely present in eukaryotic cells as the most abundant RNA modification.
Weitong Shu, Qianying Huang, Rui Chen, Huatao Lan, Luxin Yu, Kai Cui, Wanjun He, Songshan Zhu, Mei Chen, Li Li, Dan Jiang, Guangxian Xu   +11 more
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