Results 1 to 10 of about 57 (55)

The N6-Methyladenosine RNA Demethylase AlkB Homolog 5 (ALKBH5) in Metabolic Diseases: Molecular Mechanisms and Pharmacological Implications—A Review

Biomolecules
Metabolic diseases, including type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated fatty liver disease (MAFLD), are chronic disorders characterized by dysregulated glucose and lipid homeostasis and represent major contributors to insulin ...
Guida Cai, Leyi Fu, Xi Zhang, Meiling Yan   +3 more
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ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis

Molecular Therapy: Nucleic Acids, 2021
N6-methyladenosine (m6A) is the most commonly occurring internal RNA modification to be found in eukaryotic mRNA and serves an important role in various physiological events.
Hao Yu, Xiao Yang, Jinyuan Tang, Shuhui Si, Zijian Zhou, Jiancheng Lu, Jie Han, Baorui Yuan, Qikai Wu, Qiang Lu, Haiwei Yang   +10 more
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ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control

Cell Reports, 2023
Summary: N6-methyladenosine (m6A) RNA modification controls numerous cellular processes. To what extent these post-transcriptional regulatory mechanisms play a role in hematopoiesis has not been fully elucidated.
Yimeng Gao, Joshua T. Zimmer, Radovan Vasic, Chengyang Liu, Rana Gbyli, Shu-Jian Zheng, Amisha Patel, Wei Liu, Zhihong Qi, Yaping Li, Raman Nelakanti, Yuanbin Song, Giulia Biancon, Andrew Z. Xiao, Sarah Slavoff, Richard G. Kibbey, Richard A. Flavell, Matthew D. Simon, Toma Tebaldi, Hua-Bing Li, Stephanie Halene   +20 more
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ALKBH5 Regulates SPHK1-Dependent Endothelial Cell Angiogenesis Following Ischemic Stress

Frontiers in Cardiovascular Medicine, 2022
BackgroundEndothelial cells dysfunction has been reported in many heart diseases including acute myocardial infarction, and atherosclerosis. The molecular mechanism for endothelial dysfunction in the heart is still not clearly understood.
Rajesh Kumari, Roshan Dutta, Prabhat Ranjan, Zainab Gbongbo Suleiman, Sumanta Kumar Goswami, Jing Li, Harish Chandra Pal, Suresh Kumar Verma, Suresh Kumar Verma   +8 more
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ALKBH5 promotes hypopharyngeal squamous cell carcinoma apoptosis by targeting TLR2 in a YTHDF1/IGF2BP2-mediated manner

Cell Death Discovery, 2023
Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the most aggressive cancers and is notorious for its extremely poor prognosis. However, very few molecular biological studies have been performed.
Jing Ye, Yuting Wu, Yao Chen, Yiyue Ren, Xiaohua Jiang, Zhihuai Dong, Jingna Zhang, Mao Jin, Xiaozhen Chen, Zhanggui Wang, Mang Xiao   +10 more
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K235 acetylation couples with PSPC1 to regulate the m6A demethylation activity of ALKBH5 and tumorigenesis

Nature Communications, 2023
N6-methyladenosine (m6A) modification plays important roles in bioprocesses and diseases. AlkB homolog 5 (ALKBH5) is one of two m6A demethylases.
Xiao-Lan Zhang, Xin-Hui Chen, Binwu Xu, Min Chen, Song Zhu, Nan Meng, Ji-Zhong Wang, Huifang Zhu, De Chen, Jin-Bao Liu, Guang-Rong Yan   +10 more
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The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

Molecular Cancer, 2022
Background N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) remains elusive. Methods In this study,
Shufang Jin, Mingyu Li, Hanyue Chang, Ruijie Wang, Zhiyuan Zhang, Jianjun Zhang, Yue He, Hailong Ma   +7 more
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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

Cell Reports, 2023
Summary: Retinal pigment epithelium (RPE) dysfunction and choroidal neovascularization (CNV) are predominant features of age-related macular degeneration (AMD), with an unclear mechanism.
Ru-Xu Sun, Hong-Jing Zhu, Ye-Ran Zhang, Jia-Nan Wang, Ying Wang, Qiu-Chen Cao, Jiang-Dong Ji, Chao Jiang, Song-Tao Yuan, Xue Chen, Qing-Huai Liu   +10 more
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Parent tRNA Modification Status Determines the Induction of Functional tRNA-Derived RNA by Respiratory Syncytial Virus Infection

Viruses, 2022
tRNA-derived RNA fragments (tRFs) are a recently discovered family of small noncoding RNAs (sncRNAs). We previously reported that respiratory syncytial virus (RSV) infection induces functional tRFs, which are derived from a limited subset of parent tRNAs,
Eun-Jin Choi, Wenzhe Wu, Ke Zhang, Xiaohong Yuan, Junfang Deng, Deena Ismail, Darby L. Buck, Kerrie S. Thomason, Roberto P. Garofalo, Shenglong Zhang, Xiaoyong Bao   +10 more
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ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Experimental Hematology & Oncology, 2023
Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a variety of methyltransferases and
Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu   +9 more
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