Results 21 to 30 of about 57 (55)

Mechanistic insights into the role of RNA demethylase ALKBH5 in malignant tumor therapy

Journal of Translational Medicine
m6A RNA methylation represents the most prevalent epitranscriptomic modification and modulates diverse dimensions of RNA metabolism. As a dynamic and reversible post-transcriptional mark, m6A is broadly distributed across multiple RNA types, including ...
Ruijie An, Yingjie Shao, Wendong Gu
doaj   +1 more source

ALKBH5 induces macrophage activation to promote renal fibrosis via Retnla

Renal Failure
Renal fibrosis is a common pathological endpoint of various chronic kidney diseases. Macrophages play an important role in the pathophysiological process of renal fibrosis.
Long Zheng, Wenjun Gao, Zhenan Zhang, An He, Qi Huangfu, Jinyu Luo, Ming Wang, Juntao Chen, Ming Cai   +8 more
doaj   +1 more source

Demethylase ALKBH4 Inhibits Cell Proliferation via Induction of 5′-tsRNAGlu in Non-Small Cell Lung Cancer

Frontiers in Bioscience-Landmark
Background: Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are an emerging class of small non-coding RNAs that play critical roles in tumor progression; however, the functions and underlying mechanisms of tsRNAs in lung cancer ...
Chuanlin Shen, Haimei Cheng, Yiling Liu, Dandan Xu, Weijie Ding, Miaoyan Pu, Luyu Shi, Jiaxin Tian, Ying Zhang   +8 more
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m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science
The transmembrane and coiled‐coil domains 3 (TMCO3) are highly expressed in many tumors. However, the underlying mechanisms governing the way in which TMCO3 affects the progression of hepatocellular carcinoma (HCC) remain unclear.
Xinxin Li, Mengzhen Han, He Zhu, Yonglong Pan, Chen Su, Yachong Liu, Zhibin Liao, Bixiang Zhang, Xiaoping Chen   +8 more
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ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction [PDF]

PeerJ
Background As one of the most common and abundant internal modifications of eukaryotic mRNA, N6-methyladenosine (m6A) modifications are closely related to placental development. Ferroptosis is a newly discovered form of programmed cell death.
Chuanmei Qin, Jiayi Wu, Xiaowei Wei, Xueqing Liu, Yi Lin   +4 more
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Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer

Advanced Science
Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti‐ferroptosis therapy. Through drug screening, it is found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC to ferroptosis.
Zhou Yang, Wei Su, Qinglin Zhang, Lili Niu, Baijie Feng, Yu Zhang, Feng Huang, Jiaxin He, Qinyao Zhou, Xin Zhou, Longjun Ma, Jingwan Zhou, Yuanrong Wang, Wenjing Xiong, Jun Xiang, Zhilin Hu, Qiang Zhan, Bing Yao   +17 more
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Aging‐Associated ALKBH5‐m6A Modification Exacerbates Doxorubicin‐Induced Cardiomyocyte Apoptosis Via AT‐Rich Interaction Domain 2

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Chemotherapy‐induced cardiovascular disease is a growing concern in the elderly population who have survived cancer, yet the underlying mechanism remains poorly understood.
Runtai Chen, Guogang Zhang, Kun Sun, Alex F. Chen   +3 more
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The m6A demethylases FTO and ALKBH5 aggravate the malignant progression of nasopharyngeal carcinoma by coregulating ARHGAP35

Cell Death Discovery
N 6-methyladenosine (m6A) is an RNA modification that can be removed by demethylases [fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5)], which regulate gene expression and cell function.
Zhiyuan Yang, Siyu Zhang, Jiayan Xiong, Tian Xia, Rui Zhu, Mengyu Miao, Keying Li, Wenyue Chen, Lin Zhang, Yiwen You, Bo You   +10 more
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ALKBH5 promotes hepatocellular carcinoma cell proliferation, migration and invasion by regulating TTI1 expression

Biomolecules & Biomedicine
The objective of this research was to investigate the potential mechanisms of AlkB homolog 5, RNA demethylase (ALKBH5) in hepatocellular carcinoma (HCC).
Qimeng Chang, Xiang Zhou, Huarong Mao, Jinfeng Feng, Xubo Wu, Ziping Zhang, Zhiqiu Hu   +6 more
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ALKBH5 promotes non-small cell lung cancer progression and susceptibility to anti-PD-L1 therapy by modulating interactions between tumor and macrophages

Journal of Experimental & Clinical Cancer Research
Background Understanding the mechanisms that mediate the interaction between tumor and immune cells may provide therapeutic benefit to patients with cancer.
Xin Hua, Qiuli Xu, Ranpu Wu, Wei Sun, Yanli Gu, Suhua Zhu, Xin Liu, Tangfeng Lv, Yong Song   +8 more
doaj   +1 more source