Results 111 to 120 of about 1,458 (131)

ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer [PDF]

British Journal of Cancer, 2011
We have demonstrated for the first time that a novel human AlkB homologue, ALKBH3, contributes to prostate cancer development, but its clinical and biological roles in lung cancer remain unclear.Expression of both mRNA and protein of PCA-1 was examined by RT-PCR and western blotting.
M Tasaki, N Konishi, Konishi N
exaly   +3 more sources

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Sensitive Measurement of ALKBH3 Activity using a Dual DNA Amplifier by Coupling DNA Circuits with CRISPR/Cas12a

ChemistrySelect, 2023
Abstract DNA repair enzyme ALKBH3 has shown great potential as diagnostic as well as therapeutic target for several cancers. However, methods for the sensitive measurement of ALKBH3 repair activity are highly desirable but challenging.
Zhenkun Wu, Ying Long
exaly   +2 more sources

Abstract 4034: ALKBH3 deficiency and liability to alkylating agents in CRC models

Cancer Research, 2022
Abstract Colorectal cancer (CRC) is the third most frequent malignancy and the second leading cause of cancer death worldwide. Despite the increase in therapeutic options for the treatment of metastatic CRC (mCRC), cytotoxic chemotherapy using fluoropyrimidines, oxaliplatin, and irinotecan still constitutes the mainstay of the treatment.
Pietro Paolo Vitiello, Elisa Mariella, Pietro Andrei, Vito Amodio, Giovanni Germano, Annalisa Lorenzato, Carlotta Cancelliere, Alberto Bardelli   +7 more
openaire   +1 more source

Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker [PDF]

Journal of the American Chemical Society, 2016
The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitumor target and a potential diagnostic marker for several tumor types, including prostate cancer. However, there is at present no simple way to measure this enzyme's activity. Here we describe a fluorogenic probe design (MAQ) that is directly responsive to ALKBH3 repair activity.
Andrew A Beharry, Eric T Kool
exaly   +5 more sources

Contrasting role of ASCC3 and ALKBH3 in determining genomic alterations in Glioblastoma Multiforme

Journal of Emerging Investigators, 2022
Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). Methylation status of O-6-methylguanine-DNA methyltransferase (MGMT) is the most promising biomarker known to have better therapy prediction and prognosis.
Ananya Sriram, Jeru Manoj Manuel
openaire   +1 more source

DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation [PDF]

Molecular Cell, 2011
Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little is known about their functions in mammalian cells. We report the purification of the ALKBH3 complex and demonstrate its association with the activating signal cointegrator complex (ASCC).
Sebastian Dango, Nima Mosammaparast, Mathew E Sowa   +2 more
exaly   +4 more sources

Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3

Bioorganic & Medicinal Chemistry, 2018
The mammalian AlkB homologue-3 (AlkBH3) is a member of the dioxygenase family of enzymes that in humans is involved in DNA dealkylation repair. Because of its role in promoting tumor cell proliferation and metastasis of cancer, extensive efforts are being directed in developing selective inhibitors for AlkBH3.
Richa Nigam, Kaki Raveendra Babu, Topi Ghosh, Bhavini Kumari, Deepa Akula, Subha Narayan Rath, Prolay Das, Roy Anindya, Faiz Ahmed Khan   +8 more
openaire   +3 more sources

PCA-1/ALKBH3 Contributes to Pancreatic Cancer by Supporting Apoptotic Resistance and Angiogenesis

Cancer Research, 2012
AbstractThe PCA-1/ALKBH3 gene implicated in DNA repair is expressed in several human malignancies but its precise contributions to cancer remain mainly unknown. In this study, we have determined its functions and clinical importance in pancreatic cancer.
Ichiro, Yamato, Masayuki, Sho, Keiji, Shimada, Kiyohiko, Hotta, Yuko, Ueda, Satoshi, Yasuda, Naoko, Shigi, Noboru, Konishi, Kazutake, Tsujikawa, Yoshiyuki, Nakajima   +9 more
openaire   +2 more sources

Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells [PDF]

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2019
In ovarian and breast cancers, the actions of the cytokine CSF-1 lead to poor prognosis. CSF-1 expression can be regulated post-transcriptionally. RNA methylation is another layer of posttranscriptional regulation. The methylation of N1 atom of adenine (m1A) results in a conformational change of RNA which regulates translational efficiency.
Ho-Hyung Woo, Setsuko K Chambers
exaly   +3 more sources

Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma

Oncology Reports, 2015
Prostate cancer antigen-1 (PCA-1)/ALKBH3 has been recently identified in human prostate cancer and its expression is correlated with disease progression and prognosis. However, the precise role and function of PCA-1/ALKBH3 in human malignancies are largely unknown.
Masayuki Sho, Kiyohide Fujimoto, Keiji Shimada   +2 more
exaly   +4 more sources