Results 111 to 120 of about 1,461 (131)
m1A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma. [PDF]
BMC CancerWu Y +10 more
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Talanta, 2022
ALKBH3 is an important marker for early diagnosis and histopathological grading of prostate cancer. However, the lack of a rapid and sensitive method to quantify the enzyme's activity in the current time necessitates the development of a new quantitative assay.
Jinlong Li +2 more
exaly +3 more sources
ALKBH3 is an important marker for early diagnosis and histopathological grading of prostate cancer. However, the lack of a rapid and sensitive method to quantify the enzyme's activity in the current time necessitates the development of a new quantitative assay.
Jinlong Li +2 more
exaly +3 more sources
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer [PDF]
British Journal of Cancer, 2011 We have demonstrated for the first time that a novel human AlkB homologue, ALKBH3, contributes to prostate cancer development, but its clinical and biological roles in lung cancer remain unclear.Expression of both mRNA and protein of PCA-1 was examined by RT-PCR and western blotting.
Konishi N, N Konishi, Shimada K
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Contrasting role of ASCC3 and ALKBH3 in determining genomic alterations in Glioblastoma Multiforme
Journal of Emerging Investigators, 2022Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). Methylation status of O-6-methylguanine-DNA methyltransferase (MGMT) is the most promising biomarker known to have better therapy prediction and prognosis.
Ananya Sriram, Jeru Manoj Manuel
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Abstract 4034: ALKBH3 deficiency and liability to alkylating agents in CRC models
Cancer Research, 2022Abstract Colorectal cancer (CRC) is the third most frequent malignancy and the second leading cause of cancer death worldwide. Despite the increase in therapeutic options for the treatment of metastatic CRC (mCRC), cytotoxic chemotherapy using fluoropyrimidines, oxaliplatin, and irinotecan still constitutes the mainstay of the treatment.
Pietro Paolo Vitiello +7 more
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Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker [PDF]
Journal of the American Chemical Society, 2016 The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitumor target and a potential diagnostic marker for several tumor types, including prostate cancer. However, there is at present no simple way to measure this enzyme's activity. Here we describe a fluorogenic probe design (MAQ) that is directly responsive to ALKBH3 repair activity.
Eric Kool, Timothy R O'Connor
exaly +5 more sources
ChemistrySelect, 2023
Abstract DNA repair enzyme ALKBH3 has shown great potential as diagnostic as well as therapeutic target for several cancers. However, methods for the sensitive measurement of ALKBH3 repair activity are highly desirable but challenging.
Ying Long
exaly +2 more sources
Abstract DNA repair enzyme ALKBH3 has shown great potential as diagnostic as well as therapeutic target for several cancers. However, methods for the sensitive measurement of ALKBH3 repair activity are highly desirable but challenging.
Ying Long
exaly +2 more sources
Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3
Bioorganic & Medicinal Chemistry, 2018The mammalian AlkB homologue-3 (AlkBH3) is a member of the dioxygenase family of enzymes that in humans is involved in DNA dealkylation repair. Because of its role in promoting tumor cell proliferation and metastasis of cancer, extensive efforts are being directed in developing selective inhibitors for AlkBH3.
Richa Nigam +8 more
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DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation [PDF]
Molecular Cell, 2011 Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little is known about their functions in mammalian cells. We report the purification of the ALKBH3 complex and demonstrate its association with the activating signal cointegrator complex (ASCC).
Feizhen Wu, Mark Rubin
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