Results 11 to 20 of about 3,618 (129)

Environmentally benign glycosylation of aryl pyranosides and aryl/alkyl furanosides demonstrating the versatility of thermostable CGTase from Thermoanaerobacterium sp. [PDF]

, 2014
International audienceAn extensive study on the specificity of transglycosylation and disproportionation of Thermoanaerobacterium sp. cyclodextrin glucosyltranferases against aryl glucopyranosides or furanosides was achieved. While a mixture of maltoside
Chauvin, Anne-Laure, Ferrières, Vincent, Herrera-Estrella, Luis, Legentil, Laurent, Nugier-Chauvin, Caroline, Pennec, Alizé   +5 more
core   +3 more sources

Method of identifying inhibitors of glutathione S-transferase (GST) gene expression [PDF]

, 1999
Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer.
Akande, Olanike, Ali-Osman, Francis, Antoun, Gamil, Buolamwini, John K., Keller, Charles W., Lo, Hui-Wen, Lopez-Berestein, Gabriel   +6 more
core   +1 more source

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors [PDF]

, 2012
N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei.
Alan H. Fairlamb, Bowyer P. W., Brenk R., Brown D. L., Daniel Spinks, David A. Robinson, Devadas B., Devadas B., Ebara S., Ebara S., Ebiike H., Emsley P., Frearson J. A., Frearson J. A., Gelb M. H., Hertz-Fowler C., Hirumi H., Hopkins A. L., Ian H. Gilbert, Irene Hallyburton, Jacobs R. T., Julie A. Frearson, Justin R. Harrison, Kawasaki K., Kevin D. Read, Laste Stojanovski, Laura A. T. Cleghorn, Leah S. Torrie, Masubuchi M., Masubuchi M., Maurer-Stroh S., McWherter C. A., Michael A. J. Ferguson, Murshudov G. N., Nagarajan S. R., Neil R. Norcross, Otwinowski Z., Panethymitaki C., Parkin A., Paul G. Wyatt, Polli J. W., Price H. P., Price H. P., Raz B., Ruth Brenk, Schuttelkopf A. W., Sikorski J. A., Stephen Brand, Stuart P. McElroy, Suzanne Norval, Tracy Bayliss, Vagin A., Victoria C. Smith, Yamazaki K.   +53 more
core   +4 more sources

Chemical proteomics approaches for identifying the cellular targets of natural products. [PDF]

, 2016
Covering: 2010 up to 2016. Deconvoluting the mode of action of natural products and drugs remains one of the biggest challenges in chemistry and biology today.
Abegg, Abo, Agard, Alexander, Bachovchin, Bantscheff, Bantscheff, Bateman, Battenberg, Boersema, Boger, Broncel, Broncel, Böttcher, Böttcher, Böttcher, Cassiano, Charron, Cravatt, Dubinsky, Dubinsky, Eirich, Eirich, Ekkebus, Evans, Evans, Fischer, Fonovic, Geiger, Gersch, Heal, Hentzer, Heydenreuter, Hulce, Ishihama, Ismail, Ismail, Iwamaru, Kalesh, Kocaoglu, Koch, Kreuzer, Krysiak, La Clair, Lajkiewicz, Lanning, Lehmann, Leonti, Li, Li, Li, List, M. H. Wright, Mackinnon, MacKinnon, Martinez Molina, Meissner, Mellacheruvu, Moellering, Nahnsen, Nessen, Nickel, Nishino, Nodwell, Nordin, Old, Orth, Park, Patricelli, Patterson, Pitscheider, Preston, Rask-Andersen, Ravindran, Romeo, Rostovtsev, Rudolf, S. A. Sieber, Savitski, Schneider, Shannon, Shi, Shibata, Sibbersen, Smith, Speers, Speers, Srinivas, Staub, Staub, Stolze, Suchanek, Teplitski, Tietze, Tornoe, Trzoss, Vila, Wang, Wang, Wang, Wang, Wang, Wang, Weerapana, Weerapana, Weerapana, Weichert, White, White, Wirth, Wirth, Wittelsberger, Wright, Wright, Yang, Yang, Yang, Yang, Yang, Yu, Yu, Zeiler, Zhao, Zheng, Zhou, Ziegler   +125 more
core   +1 more source

Biocatalytic Friedel-Crafts Reactions [PDF]

, 2022
Friedel-Crafts alkylation and acylation reactions are important methodologies in synthetic and industrial chemistry for the construction of aryl-alkyl and aryl-acyl linkages that are ubiquitous in bioactive molecules. Nature also exploits these reactions
Leveson-Gower, Reuben B., Roelfes, Gerard   +1 more
core   +1 more source

Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]

, 2016
Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina, Pertusati, Fabrizio, Serpi, Michaela   +2 more
core   +1 more source

Creation and evolution of organocatalytic artificial enzymes [PDF]

, 2023
Leven is afhankelijk van chemische reacties die allerlei verschillende functies mogelijk maken, en veel van deze reacties moeten worden versneld omdat ze anders extreem traag zouden zijn.
Leveson-Gower, Reuben Boddington
core   +2 more sources

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]

, 2019
The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R., Domínguez de María, Pablo, Gonzalo Calvo, Gonzalo de   +2 more
core   +3 more sources

Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage X174 lysis protein E, and cationic antibacterial peptides [PDF]

, 2016
This review covers recent developments in the inhibition of translocase MraY and related phospho-GlcNAc transferases WecA and TagO, and insight into the inhibition and catalytic mechanism of this class of integral membrane proteins from the structure of ...
Bugg, Tim, Jamshidi, Shirin, Mihalyi, Agnes, Rodolis, Maria T.   +3 more
core   +1 more source

Inhibitory effect of 2,3,5,6-tetrafluoro-4-[4-(Aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide derivatives on HIV reverse transcriptase associated rnase H activities [PDF]

, 2016
The HIV-1 ribonuclease H (RNase H) function of the reverse transcriptase (RT) enzyme catalyzes the selective hydrolysis of the RNA strand of the RNA:DNA heteroduplex replication intermediate, and represents a suitable target for drug development.
Carcelli, Mauro, Corona, Angela, Esposito, Francesca, Grandi, Nicole, Naesens, Lieve, Pala, Nicolino, Palomba, Michele, Rogolino, Dominga, Sanna, Vanna, Sechi, Mario, Tramontano, Enzo   +10 more
core   +2 more sources