Results 31 to 40 of about 3,618 (129)

Deprotective Functionalization: An Emerging Concept for Amine Reactivity

Chemistry – A European Journal, Volume 32, Issue 4, 23 January 2026.
While protecting groups are indispensable in total synthesis to avoid undesired reactivity, installation and removal of protecting groups lead to an increase in the step‐count, cost, waste production and time requirement. One approach tackling these drawbacks is deprotective functionalization, which combines deprotection and postfunctionalization in a ...
Irmgard Tiefenbrunner, Saad Shaaban, Nuno Maulide   +2 more
wiley   +1 more source

The past and future of enzyme measurements using surface enhanced Raman spectroscopy [PDF]

, 2010
The ability to accurately and sensitively measure the activity of specific enzymes is central to many aspects of modern chemistry and when combined with new nanoscience based approaches, offers significant opportunities for advancing other scientific ...
Bailo, Baker, Banholzer, Benkovic, Bjerneld, Bonifacio, Bonifacio, Broderick, Campbell, Chourpa, Cohen, Constantino, Copeland, Cui, Dick, Dieringer, Dieringer, Dou, Enright, Etchegoin, Etchegoin, Faulds, Faulds, Fleischmann, Garcia-Viloca, Gole, Gorris, Graham, Hawi, Hedstrom, Hrabakova, Ingram, Ingram, Ingram, Ingram, International Human Genome Sequencing Consortium, Jarvis, Johnson, Kneipp, Kneipp, Lal, Le Ru, Macaskill, Mantelingu, McAnally, McHugh, Min, Moore, Morjani, Moskovits, Moskovits, Murgida, Murza, Nie, Otto, Pieczonka, Pieczonka, Pieczonka, Rissin, Rohr, Rondelez, Rospendowski, Ruan, Sharma, Shin, Stevenson, Tang, Thompson, Todorovic, Wahler, Wu, Xiao, Xiao, Xiao, Xiao, Xu, Yue, Zhao, Zhou   +78 more
core   +1 more source

Structure and catalytic properties of human glutathione transferase p1-1 [PDF]

, 2013
Glutathione transferases (EC 2.5.1.18, GSTs) catalyze the nucleophilic attack of glutathione (GSH) on the electrophilic centre of a number of electrophilic compounds helping to detoxify a diverse array of toxic xenobiotics including carcinogenic, and ...
Chatzikonstantinou, Marianna, Chronopoulou, Evangelia, Labrou, Nikolaos E., Madesis, Panagiotis, Nianiou-Obeidat, Irini   +4 more
core  

Relating the metatranscriptome and metagenome of the human gut [PDF]

, 2014
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R., Chan, Andrew T., Ciulla, Dawn, Earl, Ashlee M., Franzosa, Eric A., Garrett, Wendy S., Gevers, Dirk, Giannoukos, Georgia, Huttenhower, Curtis, Izard, Jacques, Morgan, Xochitl C., Reyes, Joshua, Segata, Nicola, Waldron, Levi   +13 more
core   +2 more sources

Arylcoumarin and novel biscoumarin derivatives as potent inhibitors of human glutathione S-transferase [PDF]

, 2023
A series of arylcoumarin derivatives and two novel biscoumarin derivatives were investigated for their human recombinant glutathione S-transferase P1-1 (GSTP1-1) enzyme inhibitory activities for the first time.
Danis, Özkan, Meletli, Furkan, Orhan, Berk, Çakmakcı, Emrah, Özalp, Lalehan   +4 more
core   +1 more source

A Modular Biosensor Platform for the Detection of Plastic Monomers and the Engineering of Promiscuous Amidases Toward Challenging Substrates

Advanced Science, Volume 13, Issue 6, 30 January 2026.
A luciferase is used as biosensor for aldehydes, produced enzymatically from different monomeric building blocks of plastics like polyurethanes (PUs). The screening platform is used to monitor esterase, amidase, and urethanase activity and to guide the selection of enzyme variants with improved hydrolytic activities toward difficult to hydrolyze ...
Ina Somvilla, Hannah Meier, Florian Oehlschläger, Hannes Meinert, Lena Koch, Patrick Ihrle, Katharina M. Mehnert, Morten Flieger, Jonas Boß, Marco Seifert, Dominique Böttcher, Uwe T. Bornscheuer, Thomas Bayer   +12 more
wiley   +1 more source

Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ortho‐Substituted Azobenzenes and Azonium Ions

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano, Rosa Márquez García, Wiktor Szymanski   +2 more
wiley   +2 more sources

Microbial β-Glucosidase: sources, production and applications [PDF]

, 2017
Cellulose is the most abundant biopolymer in biosphere and the major constituent of plant biomass. Cellulose polymer is made up of β-glucose units linked by β-glucosidic bonds. Cellulase is an enzymatic system that catalyzes the hydrolysis of cellulose
Ahmed, Amer, Batool, Kashfa, Bibi, Aasia, Nasim Faiz, ul-Hassan   +3 more
core  

Fragment-based approaches to TB drugs. [PDF]

, 2018
Tuberculosis is an infectious disease associated with significant mortality and morbidity worldwide, particularly in developing countries. The rise of antibiotic resistance in Mycobacterium tuberculosis (Mtb) urgently demands the development of new drug ...
Abell, Chris, Chan, Daniel SH, Coyne, Anthony G, Marchetti, Chiara   +3 more
core   +1 more source

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang, Yuyu Zhang, Yibo Chen, Wen Zhong, Subei Tan, Jinghuan Wang, Huanren Yan, Ning Yan, Mengjia Lin, Xinhua Liu, Jun Chang   +10 more
wiley   +1 more source