Results 1 to 10 of about 50 (49)
Alkylating Agents Stronger than Alkyl Triflates [PDF]
Journal of the American Chemical Society, 2004 A new class of potent electrophilic "R(+)" alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB(11)Me(5)X(6)) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions with conventional alkylating agents such as alkyl triflates, using the high oxophilicity of silylium ...
Kato, Tsuyoshi +4 more
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Carcinogenicity of Alkylating Agents [PDF]
Public Health Reports (1896-1970), 1966 T O A CHEMIST interested in carcinogenesis, one of its fascinating aspects is the great variety of chemicals that after being administered to a test animal can lead to cancer. Some very simple molecules, that is, carbon tetrachloride or diazomethane, are carcinogenic in certain species of animals while in others only complex structures are cancer ...
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Letter: Alkylating agents and myeloma cells [PDF]
Blood, 1976 alkylating agents induce a proliferative response in myeloma ...
A. Pileri, CONTE, PIERFRANCO, N. Hulin
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ON THE MUTAGENIC EFFECT OF ALKYLATING AGENTS [PDF]
Proceedings of the National Academy of Sciences, 1960 Ekkehard Bautz, Ernst Freese
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Enzyme activated alkylating agents [PDF]
British Journal of Cancer, 1973 C R Ball, J A Double, J Goodban
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ChemInform Abstract: ORGANOBORANES AS ALKYLATING AGENTS [PDF]
Chemischer Informationsdienst, 1976 AbstractDurch Umsetzung von 1‐Hexen (I) mit Boran‐Dimethylsulfid in Äther wird Trihexylboran (II) erhalten, das mit Methylvinylketon (III) in einer Radikalkettenreaktion in 8l%iger Gesamtausbeute zu 2‐Decanon (IV) reagiert.
Gary W. Neal +2 more
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Some of the next articles are maybe not open access.
Alkylating Agents in Bronchogenic Carcinoma
Journal of Occupational and Environmental Medicine, 1969Abstract A large number of patients in a group of Veterans Administration Hospitals received a variety of alkylating agents in studies in which these agents were randomized with an inert compound. Intravenous cyclophosphamide, and possibly nitrogen mustard, had a slight favorable influence upon survival for all patients.
Edward Humphrey +3 more
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1989
The phenotypic expression of intrinsic or natural resistance and the selection of acquired resistance through sublethal exposure to anticancer agents remain major obstacles to the successful treatment of human neoplasms. A large number of solid tumors that fail to respond to chemotherapy do so because they possess characteristics that allow them to ...
Kenneth D. Tew, Margie L. Clapper
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The phenotypic expression of intrinsic or natural resistance and the selection of acquired resistance through sublethal exposure to anticancer agents remain major obstacles to the successful treatment of human neoplasms. A large number of solid tumors that fail to respond to chemotherapy do so because they possess characteristics that allow them to ...
Kenneth D. Tew, Margie L. Clapper
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Bulletin du cancer, 2011
With the approval of mechlorethamine by the FDA in 1949 for the treatment of hematologic malignancies, alkylating agents are the oldest class of anticancer agents. Even though their clinical use is far beyond the use of new targeted therapies, they still occupy a major place in specific indications and sometimes represent the unique option for the ...
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With the approval of mechlorethamine by the FDA in 1949 for the treatment of hematologic malignancies, alkylating agents are the oldest class of anticancer agents. Even though their clinical use is far beyond the use of new targeted therapies, they still occupy a major place in specific indications and sometimes represent the unique option for the ...
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On the Biological Alkylating Agents
Perspectives in Biology and Medicine, 1973Les poisons peuvent etre employes comme agents de destruction de la vie ou comme moyens de guerison des maladies; mais, outre ces deux usages bien connus de tout le monde, il en est un troisieme qui interesse particulierement le physiologiste. Pour lui, le poison devient un instrument qui dissocie et analyse les phenomenes les plus delicats de la ...
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