Results 1 to 10 of about 3,196,403 (286)
Temozolomide and Other Alkylating Agents in Glioblastoma Therapy
Biomedicines, 2019 The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly aggressive and lethal primary brain tumor.
Hannah Strobel +7 more
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Cell Reports, 2015 Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients.
Pu Wang +10 more
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HEMATOLOGICAL EFFECTS OF THE ALKYLATING AGENTS [PDF]
Annals of the New York Academy of Sciences, 1958 L. A. Elson
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Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
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Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. [PDF]
PLoS Genetics, 2013 Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues.
Jennifer A Calvo +10 more
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Alkylating Agents Stronger than Alkyl Triflates [PDF]
Journal of the American Chemical Society, 2004 A new class of potent electrophilic "R(+)" alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB(11)Me(5)X(6)) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions with conventional alkylating agents such as alkyl triflates, using the high oxophilicity of silylium ...
Kato, Tsuyoshi +4 more
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Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. [PDF]
PLoS ONE, 2011 First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis ...
Steve Quiros +2 more
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Biosynthesis of DNA-Alkylating Antitumor Natural Products
Molecules, 2022 DNA-alkylating natural products play an important role in drug development due to their significant antitumor activities. They usually show high affinity with DNA through different mechanisms with the aid of their unique scaffold and highly active ...
Qiu-Yue Nie +3 more
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Effect of curcumin on the genotoxicity induced by alkylating agents
Frontiers in Genetics, 2015 The protection of the structure of DNA is extremly important to transfer genetic information from generation to generation. DNA damage due to genotoxic ess is an important type of stress which organisms are exposed during their life.
İbrahim Hakkı Ciğerci
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Monocytosis and Multiple Myeloma: treatment-related acute leukaemia?
Surgical and Experimental Pathology, 2022 Background Therapy-related acute monocytic leukemias in patients with plasma cell dyscrasias are infrequent. Case presentation We here present a case of a 60 year old female who developed an acute monocytic leukemia two years after the diagnosis of ...
Cristina Veronica Trinidad Esparza +4 more
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