Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders
Advanced Science, EarlyView.Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li +7 more
wiley +1 more source
Temozolomide-Induced Myelodysplasia
Advances in Hematology, 2010 A patient who had received temozolomide (TMZ) as a single agent in treatment of malignant glioma developed therapy-induced myelodysplasia (T-MDS). TMZ is an orally active imidazotetrazine which methylates guanine residues in DNA, ultimately causing ...
Ethan A. Natelson, David Pyatt
doaj +1 more source
Advanced Science, EarlyView.This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su +18 more
wiley +1 more source
Emerging Memory and Device Technologies for Hardware‐Accelerated Model Training and Inference
Advanced Electronic Materials, EarlyView.This review investigates the suitability of various emerging memory technologies as compute‐in‐memory hardware for artificial intelligence (AI) applications. Distinct requirements for training‐ and inference‐centric computing are discussed, spanning device physics, materials, and system integration.
Yoonho Cho +6 more
wiley +1 more source
Stabilization of Polystyrene by Friedel-Crafts Chemistry: Effect of Position of Alcohol and the Catalyst [PDF]
, 1999 Polystyrene has been copolymerized with 4-vinylbenzyl alcohol, 4-(2-hydroxyethyl)styrene, and 4-(3-hydroxypropyl)styrene and it has been shown that thermal cross-linking of these copolymers is dependent upon the alcohol content.
McKinney, Michael A. +2 more
core +1 more source
Response to the feasibility of Kreher et al’s “Risk of melanoma and nonmelanoma skin cancer with immunosuppressants, part II: methotrexate, alkylating agents, biologics, and small molecule inhibitors” [PDF]
, 2023 Katelyn J. Rypka +2 more
openalex +1 more source
Clinical evaluation of a new alkylating agent: Cytoxan (cyclophosphamide) [PDF]
, 1960 Peter R. Coggins +2 more
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Nature CommunicationsRegioselective arene C−H bond alkylation is a powerful tool in synthetic chemistry, yet subject to many challenges. Herein, we report the meta-C−H bond alkylation of aromatics bearing N-directing groups using (hetero)aromatic epoxides as alkylating ...
Peng-Bo Bai +3 more
doaj +1 more source
Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene. [PDF]
, 1986 Hiroko Kataoka, J. Hall, Peter Karran
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