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Alkylating and Platinating Agents
2001Alkylating agents form the backbone of many anticancer regimens and are used in both conventional and high-dose therapy settings. The biologic and chemical activities of the nitrogen mustards were studied extensively between the World Wars. Because of their vesicant activity on the skin, eyes, and respiratory tract, the mustards also were studied for ...
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Alkylating and platinum-based agents
Current Opinion in ONCOLOGY, 1990Alkylating agents and platinum coordination complexes represent a major part of the therapeutic armamentarium used against almost all tumors. The alkylating agents played an important role in the development of cancer chemotherapy. The nitrogen mustard mechlorethamine evolved from sulfur mustard gas used in World War 1, and was the first nonhormonal ...
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The Metabolism of Biological Alkylating Agents
Drug Metabolism Reviews, 1974(1974). The Metabolism of Biological Alkylating Agents. Drug Metabolism Reviews: Vol. 2, No. 1, pp. 71-100.
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Reproductive Toxicology of Alkylating Agents
Obstetrical & Gynecological Survey, 1994Alkylating agents have been used during childhood and in reproductive age groups for the treatment of malignancy or collagen-vascular disease. Because of their mechanism of action, alkylating agents have the ability to interfere with chromosomal structure, ovarian function, spermatogenesis, and embryogenesis.
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The Chemistry of Cytotoxic Alkylating Agents
1953Publisher Summary A considerable amount of work has been devoted to the study of the chemotherapy of cancer using agents related to the vesicant war gas, di-2-chloroethyl sulfide (mustard gas). The first agents to be used extensively were two nitrogen mustards—methyl-di-2-chloroethylamine (HN 2 ) and tri-2-chloroethylamine (HN 3 ).
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Alkylating Agents and the Nitrosoureas
1977The alkylating agents as a group have long held the interest of both practical cancer chemotherapists and experimental pharmacologists. They have assumed this position of importance because they were among the first clinical agents of recognized value, and because their study has increased our understanding of cancer chemotherapy in general.
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Polycythemia Vera and Alkylating Agents
Annals of Internal Medicine, 1982Excerpt To the editor: The UCLA conference on polycythemia (1) contains a serious misquotation. On p.
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