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DNA minor groove alkylating agents
Expert Opinion on Therapeutic Patents, 2000Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen mustards, where attachment of the mustard unit to carrier molecules can change the normal patterns of both regio- and sequence-selectivity, from reaction primarily at most guanine N7 sites in the ...
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2005
Abstract Alkylating agents were among the first drugs to be used to treat malignant disease and form a major component of many regimens employed against both haematological and solid tumours. Their common mechanism of action is the formation of covalent adducts with the nucleotides of DNA. Subsequent processing or repair of these lesions
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Abstract Alkylating agents were among the first drugs to be used to treat malignant disease and form a major component of many regimens employed against both haematological and solid tumours. Their common mechanism of action is the formation of covalent adducts with the nucleotides of DNA. Subsequent processing or repair of these lesions
openaire +1 more source