Results 191 to 200 of about 46,126 (242)
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Alkylating Agents in Bronchogenic Carcinoma
Journal of Occupational and Environmental Medicine, 1969Abstract A large number of patients in a group of Veterans Administration Hospitals received a variety of alkylating agents in studies in which these agents were randomized with an inert compound. Intravenous cyclophosphamide, and possibly nitrogen mustard, had a slight favorable influence upon survival for all patients.
R A, Green +3 more
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1989
The phenotypic expression of intrinsic or natural resistance and the selection of acquired resistance through sublethal exposure to anticancer agents remain major obstacles to the successful treatment of human neoplasms. A large number of solid tumors that fail to respond to chemotherapy do so because they possess characteristics that allow them to ...
M L, Clapper, K D, Tew
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The phenotypic expression of intrinsic or natural resistance and the selection of acquired resistance through sublethal exposure to anticancer agents remain major obstacles to the successful treatment of human neoplasms. A large number of solid tumors that fail to respond to chemotherapy do so because they possess characteristics that allow them to ...
M L, Clapper, K D, Tew
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On the Biological Alkylating Agents
Perspectives in Biology and Medicine, 1973Les poisons peuvent etre employes comme agents de destruction de la vie ou comme moyens de guerison des maladies; mais, outre ces deux usages bien connus de tout le monde, il en est un troisieme qui interesse particulierement le physiologiste. Pour lui, le poison devient un instrument qui dissocie et analyse les phenomenes les plus delicats de la ...
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JAMA: The Journal of the American Medical Association, 1971
Eleven patients with malignant lymphoma had sperm counts done in the course of maintenance treatment with the alkylating agents chlorambucil or cyclophosphamide. Of the nine patients treated with chlorambucil, all had aspermia after treatment with doses ranging from 10.1 to 17.7 mg/kg of body weight.
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Eleven patients with malignant lymphoma had sperm counts done in the course of maintenance treatment with the alkylating agents chlorambucil or cyclophosphamide. Of the nine patients treated with chlorambucil, all had aspermia after treatment with doses ranging from 10.1 to 17.7 mg/kg of body weight.
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2005
Abstract Alkylating agents were among the first drugs to be used to treat malignant disease and form a major component of many regimens employed against both haematological and solid tumours. Their common mechanism of action is the formation of covalent adducts with the nucleotides of DNA. Subsequent processing or repair of these lesions
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Abstract Alkylating agents were among the first drugs to be used to treat malignant disease and form a major component of many regimens employed against both haematological and solid tumours. Their common mechanism of action is the formation of covalent adducts with the nucleotides of DNA. Subsequent processing or repair of these lesions
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Evolution of Nitrogen-Based Alkylating Anticancer Agents
Processes, 2021Fredrik Lehmann, Johan Wennerberg
exaly