Critical appraisal of MGMT in digestive NET treated with alkylating agents.
Endocrine-Related Cancer, 2020 The efficacy of alkylating agents (temozolomide, dacarbazine, streptozotocin) in patients with advanced neuroendocrine tumors (NETs) has been well documented, especially in pancreatic NETs. Alkylating agents transfer methyl adducts on DNA bases.
L. Mestier +15 more
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Exploring organic semiconductors in solution: The effects of solvation, alkylization, and doping [PDF]
PCCP 23, 4841 (2021), 2021 The first-principles simulation of the electronic structure of organic semiconductors in solution poses a number of challenges that are not trivial to address simultaneously. In this work, we investigate the effects and the mutual interplay of solvation, alkylization, and doping on the structural, electronic, and optical properties of sexithiophene, a ...
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Glutathione conjugates of the mercapturic acid pathway and guanine adduct as biomarkers of exposure to CEES, a sulfur mustard analog [PDF]
, 2021 Sulfur mustard (SM), a chemical warfare agent, is a strong alkylating compound that readily reacts with numerous biomolecules. The goal of the present work was to define and validate new biomarkers of exposure to SM that could be easily accessible in urine or plasma. Because investigations using SM are prohibited by the Organization for the Prohibition
arxiv +1 more source
Few layer 2D pnictogens catalyze the alkylation of soft nucleophiles with esters [PDF]
Nat. Commun. 2019, 10, 509, 2019 Group 15 elements in zero oxidation state (P, As, Sb and Bi), also called pnictogens, are rarely used in catalysis due to the difficulties associated in preparing well-structured and stable materials. Here, we report on the synthesis of highly exfoliated, few layer 2D phosphorene and antimonene in zero oxidation state, suspended in an ionic liquid ...
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HFIP Solvent Enables Alcohols To Act as Alkylating Agents in Stereoselective Heterocyclization.
Journal of the American Chemical Society, 2019 A new method for the stereoselective synthesis of highly functionalized oxygen heterocycles using allyl or benzyl alcohols as alkylating agents is presented.
Yuxiang Zhu +3 more
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First Principles Study of Photo-oxidation Degradation Mechanisms in P3HT for Organic Solar Cells [PDF]
Phys. Chem. Chem. Phys., 2014,16, 8092-8099, 2014 We present a theoretical study of degradation mechanisms for photoinduced oxidation in organic polymers in the condensed phase, using poly(3-hexylthiophene)(P3HT) as an example. Applying density functional theory with a hybrid density functional and periodic boundary conditions that account for steric effects and permit the modeling of interchain ...
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Differential proteomics highlights macrophage-specific responses to amorphous silica nanoparticles [PDF]
Nanoscale, Royal Society of Chemistry, 2017, 9 (27), pp.9641 -
9658. 10.1039/c7nr02140b, 2018 The technological and economic benefits of engineered nanomaterials may be offset by their adverse effects on living organisms. One of the highly produced nanomaterials under such scrutiny is amorphous silica nanoparticles, which are known to have an appreciable, although reversible, inflammatory potential.
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Effect of Alkyl-group Flexibility on the Melting Point of Imidazolium-based Ionic Liquids [PDF]
J. Chem. Phys. 153, 044504 (2020), 2021 The low melting point of room temperature ionic liquids is usually explained in terms of the presence of bulky, low symmetry and flexible ions, with the first two factors related to the lattice energy while an entropic effect is attributed to the latter.
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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
New England Journal of Medicine, 2000 BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a promoter; methylation of the promoter silences the gene in cancer, and the cells no ...
M. Esteller +7 more
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Tunneling conductance of amine linked alkyl chains [PDF]
Nano Lett 8, 1771 (2008), 2008 The tunneling transport theory developed in Phys. Rev. B {\bf 76}, 115102 (2007) is applied to molecular devices made of alkyl chains linked to gold electrodes via amine groups. Using the analytic expression of the tunneling conductance derived in our previous work, we identify the key physical quantities that characterize the conductance of these ...
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