Results 111 to 120 of about 224,439 (406)

A challenging redox neutral Cp*Co(III)-catalysed alkylation of acetanilides with 3-buten-2-one: synthesis and key insights into the mechanism through DFT calculations

Beilstein Journal of Organic Chemistry, 2018
Traditional, established palladium cross-coupling procedures are widely applied in complex molecule synthesis; however, there is a significant disadvantage in the requirement for pre-functionalised substrates (commonly halides/triflates).
Andrew Kenny, Alba Pisarello, Arron Bird, Paula G. Chirila, Alex Hamilton, Christopher J. Whiteoak   +5 more
doaj   +1 more source

Asymmetric synthesis of 2-substituted oxetan-3-ones via metalated SAMP/RAMP hydrazones [PDF]

, 2013
2-Substituted oxetan-3-ones can be prepared in good yields and enantioselectivities (up to 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a range of electrophiles that include alkyl, allyl, and benzyl ...
Beasley, Benjamin, Clarkson, Guy J., Geden, Joanna V., Shipman, Michael   +3 more
core   +1 more source

Molybdenum‐Catalyzed Asymmetric Amination of α‐Hydroxy Esters: Synthesis of α‐Amino Acids

Advanced Science, EarlyView.
N‐protected unnatural α‐amino acids are synthesized from α‐hydroxy esters and amines in a Mo‐catalyzed reaction. The formation of C─N bond takes place in a highly efficient way, which can be rendered asymmetric when a chiral molybdenum‐complex and chiral phosphoric acid (CPA) are used.
Shahida Perveen, Tahir Rahman, Tariq Ali, Lingyun Wang, Junjie Zhang, Ajmal Khan   +5 more
wiley   +1 more source

Study on the regioselectivity of the N-ethylation reaction of N-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Beilstein Journal of Organic Chemistry, 2019
4-Oxoquinolines are a class of organic substances of great importance in medicinal chemistry, due to their biological and synthetic versatility. N-1-Alkylated-4-oxoquinoline derivatives have been associated with different pharmacological activities such ...
Pedro N. Batalha, Luana da S. M. Forezi, Maria Clara R. Freitas, Nathalia M. de C. Tolentino, Ednilsom Orestes, José Walkimar de M. Carneiro, Fernanda da C. S. Boechat, Maria Cecília B. V. de Souza   +7 more
doaj   +1 more source

Synthesis and Cytotoxicity Evaluation of 13-<em>n</em>-Alkyl Berberine and Palmatine Analogues as Anticancer Agents

Molecules, 2012
By introducing long carbon-chain alkyl groups at the C-13 position of berberine and palmatine, 13-<em>n</em>-hexyl/13-<em>n</em>-octyl berberine and palmatine chloride analogues <strong>4a</strong>–<strong>d </
Lei Zhang, Jingjing Li, Fei Ma, Shining Yao, Naisan Li, Jing Wang, Yongbin Wang, Xiuzhen Wang, Qizheng Yao   +8 more
doaj   +1 more source

Immobilization by surface conjugation of cyclic peptides for effective mimicry of the HCV-envelope E2 protein as a strategy toward synthetic vaccines [PDF]

, 2018
Mimicry of the binding interface of antibody-antigen interactions using peptide-based modulators (i.e. epitope mimics) has promising applications for vaccine design.
Dunlop, James I., Liskamp, Rob M.J., Meuleman, Theodorus J., Owsianka, Anna M., Patel, Arvind H., van de Langemheen, Helmus   +5 more
core   +2 more sources

C-H Alkylation via Multisite-Proton-Coupled Electron Transfer of an Aliphatic C-H Bond.

Journal of the American Chemical Society, 2019
The direct, site-selective alkylation of unactivated C(sp3)-H bonds in organic substrates is a long-standing goal in synthetic chemistry. General approaches to the activation of strong C-H bonds include radical-mediated processes involving highly ...
C. Morton, Qilei Zhu, H. Ripberger, L. Troian‐Gautier, Z. S. Toa, R. Knowles, E. Alexanian   +6 more
semanticscholar   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine

Beilstein Journal of Organic Chemistry, 2010
The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl)acetic acid.
Manfred Braun, Torsten Dittrich
doaj   +1 more source

High-resolution IR absorption spectroscopy of polycyclic aromatic hydrocarbons in the 3 micron region: role of hydrogenation and alkylation [PDF]

, 2018
Aims. We aim to elucidate the spectral changes in the 3 micron region that result from chemical changes in the molecular periphery of polycyclic aromatic hydrocarbons (PAHs) with extra hydrogens (H-PAHs) and methyl groups (Me-PAHs). Methods. Advanced laser spectroscopic techniques combined with mass spectrometry were applied on supersonically cooled 1 ...
arxiv   +1 more source