Results 111 to 120 of about 253,250 (328)
Flexible synthesis of polyfunctionalised 3-fluoropyrroles [PDF]
, 2016 An efficient and selective approach for the synthesis of polyfunctionalised 3-fluoropyrroles has been developed starting from commercial aldehydes.
Cogswell, Thomas J. +2 more
core +1 more source
Stereodivergent catalytic asymmetric allylic alkylation (AAA) [PDF]
, 2020 Subarna Jyoti Kalita +2 more
openalex +1 more source
Beyond Friedel and Crafts: Innate Alkylation of C-H Bonds in Arenes.
Angewandte Chemie, 2019 Alkylated arenes are ubiquitous molecules and building blocks commonly utilized in most areas of science. Despite its apparent simplicity, the regioselective alkylation of arenes is still a challenging transformation in a lot of cases.
G. Evano, Cédric Theunissen
semanticscholar +1 more source
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, EarlyView.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Development of new supported catalysts for the continuous alkylation of amines with alcohols
Тонкие химические технологииObjectives. The work set out to develop catalysts based on nickel and copper obtained by active phase chemical reduction and investigate their activity including the influence of the type of supports on the course of alkylation of amines with primary or ...
V. M. Mokhov +5 more
doaj +1 more source
Scientia Pharmaceutica, 2017 According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics.
Liliana Azotla-Cruz +5 more
doaj +1 more source
Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation [PDF]
, 1997 Reductive activation of racemic 1,10-bis(acetoxy)-7-methoxymitosene WV15 in the presence of DNA, followed by enzymatic digestion and HPLC analysis, revealed the formation of various DNA adducts.
Duynhoven, John P.M. van +8 more
core +2 more sources
Advanced Science, EarlyView.A highly efficient method for Pd(II)–NHC (NHC = N‐heterocyclic carbene)‐catalyzed alkylation of primary amides using alkyl organozinc reagents is reported. The sterically‐hindered and readily accessible IPr* is found to be privileged for facilitating this highly challenging alkylation. Comparative studies, application to the synthesis of pharmaceutical
Peng Lei +8 more
wiley +1 more source
Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine
Beilstein Journal of Organic Chemistry, 2010 The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl)acetic acid.
Manfred Braun, Torsten Dittrich
doaj +1 more source
Synthesis of functionalized polyisobutylene and its block copolymers with D,L-lactide
Журнал Белорусского государственного университета: Химия, 2019 Method of reactive polyisobutylene modification by various alkoxybenzenes (anisole and 4-phenoxybutanol) was proposed to form functionalized polyisobutylenes.
Pavel A. Nikishau +4 more
doaj +1 more source