Results 121 to 130 of about 89,156 (285)
Ligand Relay for Nickel‐Catalyzed Decarbonylative Alkylation of Aroyl Chlorides
Advanced ScienceTransition metal‐catalyzed direct decarboxylative transformations of aromatic carboxylic acids usually require high temperatures, which limit the substrate's scope, especially for late‐stage applications.
Tian‐Zhang Wang +3 more
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The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, Accepted Article.Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl +6 more
wiley +1 more source
New Alkylation Reactions Utilizing Potassium Fluoride as the Condensing Agent.
, 1959 Kenichi Fukui +3 more
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Cytotoxicity of alkylating agents towards sensitive and resistant strains of Escherichia coli in relation to extent and mode of alkylation of cellular macromolecules and repair of alkylation lesions in deoxyribonucleic acids [PDF]
, 1968 P.D. Lawley, P. Brookes
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Alkylation of a brain transport adenosinetriphosphatase at the cardiotonic steroid site by strophanthidin-3-haloacetates. [PDF]
, 1966 L E Hokin +2 more
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Angewandte Chemie International Edition, Accepted Article.This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.A disconnection model in which acylium ions generated from acyl chlorides are treated with variety of alkenes is reported for the synthesis of 2,5‐cis‐disubstituted tetrahydrofurans (THFs) and other THF derivatives. A charge relocation process leads to the formation of oxocarbenium ions, which are reduced to the desired THF structures.
Zhi‐Jie Niu +4 more
wiley +1 more source
Convenient C-alkylation of some acyloins [PDF]
, 1969 Johan H. van de Sande, Karl R. Kopecky
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