Results 121 to 130 of about 224,439 (406)

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity [PDF]

, 2012
Alchemix is an exemplar of a class of anthraquinone with efficacy against multidrug resistant tumors. We have explored further the mechanism of action of alchemix and investigated the effect of extending its side arm bearing the alkylating functionality ...
Abdallah, QMA, Abdel-Rahman, H, Bingham, JP, Cosentino, L, Etzad, J, Hartley, JA, Helleday, D, Johansson, F, Kiakos, K, Patterson, LH, Phillips, Roger, Pors, K, Wheelhouse, RT   +12 more
core   +1 more source

Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease Activity

Advanced Science, EarlyView.
Rheumatoid arthritis is a prototypic autoimmune disease characterized by highly prevalent autoantibodies – anti‐citrullinated protein antibodies (ACPA). A novel nanoHPLC‐MS approach based on the intact Fc/2 subunit identifies hitherto neglected Fc proteoform profiles of IgG (auto)antibodies across different biofluids. The findings demonstrate subclass‐
Constantin Blöchl, Eva Maria Stork, Hans Ulrich Scherer, Rene E. M. Toes, Manfred Wuhrer, Elena Domínguez‐Vega   +5 more
wiley   +1 more source

Active species in chloroaluminate ionic liquids catalyzing low-temperature polyolefin deconstruction

Nature Communications
Chloroaluminate ionic liquids selectively transform (waste) polyolefins into gasoline-range alkanes through tandem cracking-alkylation at temperatures below 100 °C.
Wei Zhang, Rachit Khare, Sungmin Kim, Lillian Hale, Wenda Hu, Chunlin Yuan, Yaoci Sheng, Peiran Zhang, Lennart Wahl, Jiande Mai, Boda Yang, Oliver Y. Gutiérrez, Debmalya Ray, John Fulton, Donald M. Camaioni, Jianzhi Hu, Huamin Wang, Mal-Soon Lee, Johannes A. Lercher   +18 more
doaj   +1 more source

Beyond Friedel and Crafts: Innate Alkylation of C-H Bonds in Arenes.

Angewandte Chemie, 2019
Alkylated arenes are ubiquitous molecules and building blocks commonly utilized in most areas of science. Despite its apparent simplicity, the regioselective alkylation of arenes is still a challenging transformation in a lot of cases.
G. Evano, Cédric Theunissen
semanticscholar   +1 more source

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

Advanced Science, EarlyView.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li   +11 more
wiley   +1 more source

Synthesis of 1-phenyl-3-pyrroline in water

Orbital: The Electronic Journal of Chemistry, 2012
Pyrrolines are bioactive compounds and can be used as starting materials or as intermediates in the synthesis of natural products [1,2]. N-phenyl-pyrrolines have been prepared by reaction of N-propargylanilines catalyzed by Cu(I) [3] or the ring-closing ...
Thiago Muniz de Souza, Ivani Malvestiti, Lothar W. Bieber   +2 more
doaj   +1 more source

Theoretical kinetic study of thermal unimolecular decomposition of cyclic alkyl radicals [PDF]

J. Phys. Chem. A 112, 46 (2008) 11598-11610, 2009
While many studies have been reported on the reactions of aliphatic hydrocarbons, the chemistry of cyclic hydrocarbons has not been explored extensively. In the present work, a theoretical study of the gas-phase unimolecular decomposition of cyclic alkyl radicals was performed by means of quantum chemical calculations at the CBS-QB3 level of theory ...
arxiv  

Study of synthesis of 2-(2-alkoxyphenyl)-1H-imidazoles. Comparison of oxidative aromatization reactions of imidazolines [PDF]

, 2006
The reaction of methyl salicylate with ethane-1,2-diamine has been used to prepare 2-(2-hydroxyphenyl)-1H-imidazoline. This compound was alkylated with alkyl halides to give five new 2-(2-alkoxyphenyl)-1H-imidazolines (alkyl = propyl, isopropyl, isobutyl,
Handlíř, Karel, Lišková, Vlasta, Ludwig, Miroslav, Pařík, Patrik, Šenauerová, Sylva   +4 more
core   +2 more sources

Beyond Friedel and Crafts: Directed Alkylation of C-H Bonds in Arenes.

Angewandte Chemie, 2019
Alkylation of arenes is one of the most fundamental transformations in chemical synthesis and leads to privileged scaffolds in many areas of science. Classical methods for the introduction of alkyl groups to arenes are mostly based on the Friedel-Crafts ...
G. Evano, Cédric Theunissen
semanticscholar   +1 more source

ADAR1‐HNRNPL‐Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
ADAR1‐HNRNPL interaction‐repressed circCANX recruits P53 mRNA and UPF1 to assemble a complex in nuclear. This complex promotes P53 mRNA degradation through the NMD pathway, and finally reduces autophagy and stress granules formation to further regulate inflammation.
Ting‐Ting Chen, Yuan‐Yuan Wei, Jia‐Ying Kang, Da‐Wei Zhang, Jing‐Jing Ye, Xi‐Shi Sun, Mei Hong, Wen‐Ting Zhang, Hui‐Mei Wu, Zhen‐Xing Ding, Guang‐He Fei   +10 more
wiley   +1 more source