Results 161 to 170 of about 253,250 (328)

Charge‐Driven Self‐Assembly of Cholesterol Surfactants into Biofunctional Nanodiscs with Antiviral Activity

open access: yesAngewandte Chemie, EarlyView.
A modular synthesis strategy for cholesterol‐oligo‐glycerol‐based surfactants with tunable nonionic to anionic head groups is reported. The precise control of multivalent surface charges directs self‐assembly and transforms cholesterol vesicles into nanodiscs.
Yanping Long   +8 more
wiley   +2 more sources

Clinlabomics‐Enabled Blending Ensemble Learning for Low‐Cost Pan‐Cancer Detection and Classification Using Routine Clinical Laboratory Data

open access: yesAdvanced Intelligent Systems, EarlyView.
Researchers develop clinlabomics assisted for cancer identification, an artificial intelligence‐powered system using routine clinical lab data to detect and identify 10 cancer types. Tested on 19 199 individuals, it achieves 90.39% sensitivity and 82.41% specificity in cancer detection, with 72.57% accuracy in identifying specific cancer types ...
Bowen Zhang   +9 more
wiley   +1 more source

Photocatalyzed Ring Expansion of α‐Ketosulfonylaziridines: Ready Access to δ‐Sultams

open access: yesAngewandte Chemie, EarlyView.
A novel radical–polar crossover (RPC) photoredox‐catalyzed reaction for the synthesis of δ‐sultams from N‐sulfonyl α‐ketoaziridines through a controlled ring opening–expansion process is presented. This method allows the easy access to sultams with an unprecedented substitution pattern in up to 85% yield and 2:1 d.r., and highlights the potential of ...
Marco M. Mastandrea   +7 more
wiley   +2 more sources

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

open access: yesAdvanced NanoBiomed Research, EarlyView.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han   +4 more
wiley   +1 more source

Aziridine-Metathesis based Approaches to Alkaloid Synthesis [PDF]

open access: yes, 2009
The aim of the project is to synthesise (-)-morphine utilising aziridine and metathesischemistry. The thesis is divided into three chapters.Chapter 1 provides brief reviews on the subjects of total synthesis of morphine; ringrearrangementmetathesis (RRM)
Lu, Pengfei, Lu, Pengfei
core  

Dual Modality Semiconducting Polymer Nanoparticles for Use in Optical and Magnetic Resonance Imaging

open access: yesAdvanced NanoBiomed Research, EarlyView.
Well‐defined dual‐modality semiconducting polymer nanoparticles composed of red‐emitting conjugated polymers functionalized with novel gadolinium‐based contrast agents have been prepared. The assemblies show a greatly enhanced relaxivity performance compared to the clinical standard, Dotarem, while offering ultrabright fluorescence, ideal for optical ...
Faysal A. Farah   +5 more
wiley   +1 more source

Site‐Selective Peptide and Protein Functionalization with Cyclopropenium Cations

open access: yesAngewandte Chemie, EarlyView.
A cysteine‐selective bioconjugation using aromatic cyclopropenium cations is reported. The reaction proceeds rapidly under aqueous conditions, enabling site‐selective installation of tetrasubstituted cyclopropene rings on peptides and proteins. The method shows preference for internal cysteines and provides conjugates that serve as efficient radical ...
Adriana Faraone   +6 more
wiley   +2 more sources

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