Iridium-Catalyzed Enantioselective Formal α-Allylic Alkylation of Acrylonitrile [PDF]
, 2023 A highly enantioselective formal α-allylic alkylation of acrylonitrile is developed using 4-cyano-3-oxotetrahydrothiophene (c-THT) as a safe and easy-to-handle surrogate of acrylonitrile.
Pankaj, Roy, Santanu, Mukherjee
core +1 more source
Synthesis of Secondary Amines via Self-Limiting Alkylation of N-Aminopyridinium Salts [PDF]
, 2023 Partial amine alkylation to prepare secondary amines is challenging due to the enhanced N-nucleophilicity that accompanies alkylation. Here we introduce N-aminopyridinium salts as ammonia surrogates for the synthesis of secondary amines via self-limiting
David, Powers +4 more
core +2 more sources
Nickel-Catalyzed Reductive Alkylation of Heteroaryl Imines [PDF]
, 2022 A Ni-catalyzed reductive cross-coupling of heteroaryl imines with C(sp3) electrophiles for the preparation of heterobenzylic amines is reported. This umpolung-type alkylation proceeds under mild conditions, avoids the pre-generation of organometallic ...
Marco, Brandstätter +2 more
core +2 more sources
Nickel-catalyzed C-alkylation of nitroalkanes with alkyl halides
, 2022 Watson, Donald A.This dissertation focuses on the development of novel methods for nickel-catalyzed C-alkylation of nitroalkanes and mechanistic studies of them.
Rezazadeh, Sina
core +1 more source
Enantioselective Synthesis of Skipped Dienes via Iridium-Catalyzed Allylic Alkylation of Phosphonate Carbanions [PDF]
, 2022 An enantioselective synthesis of skipped diene has been developed based on an iridium-catalyzed allylic alkylation of phosphonate carbanions and Horner-Wadsworth-Emmons olefination.
Arko, Seal, Santanu, Mukherjee
core +1 more source
DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s-phase alkylation damage response in S. pombe [PDF]
, 2012 Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching ...
Koulintchenko Milana +20 more
core +2 more sources
Iridium-Catalyzed Asymmetric α-Allylic Alkylation of Amides using Vinyl Azide as Amide Enolate Surrogate [PDF]
, 2020 Among the unstabilized enolates used as nucleophile in iridium-catalyzed asymmetric allylic alkylation reactions, amide enolates are least explored. Vinyl azides are now employed as amide enolate surrogate for the first time in Ir-catalyzed asymmetric ...
Aditya, Chakrabarty, Santanu, Mukherjee
core +1 more source
New catalytic strategies for DNA and RNA alkylation using rhodium (II) and copper (I) carbenes - a versatile tool for applications in chemical biology [PDF]
, 2015 A variety of nucleic acid substrates were catalytically alkylated with rhodium(II) and copper(I)-carbenoids generated from diazocarbonyl compounds. The alkylation took place via an N-H insertion reaction selectively targeting the nucleobases in single ...
Tishinov, Kiril
core +1 more source
Catalytic Photochemical Enantioselective α-Alkylation with Pyridinium Salts [PDF]
, 2022 We have developed a chiral amine catalyzed enantioselective α-alkylation of aldehydes with amino acid derived pyridinium salts as alkylating reagents. The reaction proceeds in the presence of visible light (390 nm) and in the absence of a photocatalyst ...
Santhivardhana Reddy, Yetra +2 more
core +1 more source
Homogeneous Friedel–Crafts Alkylation
, 2023 Since its discovery in 1877, Friedel–Crafts alkylation has been one of the most significant reactions in organic chemistry. The breadth of this reaction has increased over 130 years, and it is now moving toward a more environmental friendly and ...
Dasireddy, VDBC +4 more
core +1 more source