Results 231 to 240 of about 147,295 (272)

Catalytic alkylation of unactivated C(sp3)-H bonds for C(sp3)-C(sp3) bond formation.

Chemical Society Reviews, 2019
The construction of carbon-carbon bonds is a central tenet of modern synthetic chemistry. Metal-catalyzed C-H functionalization can serve as a particularly powerful tool for achieving carbon-carbon bond formation.
Zhen Chen, Meng Rong, J. Nie, Xue-Feng Zhu, Bingfeng Shi, Jun‐An Ma   +5 more
semanticscholar   +1 more source

Alkylation of heteroaryl alkyl metals by bistrialkylsilylperoxides

Tetrahedron, 1990
AbstractHeteroalkyl methyl metals obtained from (III)/LDA undergo methylation upon treatment with the silylperoxide (I) to give the compounds (IV); in addition, the trimethylsilyloxylation products (Va) and (Vb) as well as the silylation product (VIa) are formed.
E. Epifani, Saverio Florio, Luigino Troisi   +2 more
openaire   +3 more sources

Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines

Nature, 2023
Ji-jun Chen, Jia-Heng Fang, Xuan-Yi Du, Jia-Yong Zhang, Jun-Qian Bian, Fu-Li Wang, Cheng Luan, Wei-Long Liu, Ji-Ren Liu, Xiao-Yang Dong, Zhong-Liang Li, Qiangshuai Gu, Zhe Dong, Xin‐Yuan Liu   +13 more
semanticscholar   +1 more source

Nucleophile-Dependent Z/ E- and Regioselectivity in the Palladium-Catalyzed Asymmetric Allylic C-H Alkylation of 1,4-Dienes.

Journal of the American Chemical Society, 2019
The asymmetric allylic alkylation (AAA), which features employing active allylic substrates, has historical significance in organic synthesis.
Hua-Chen Lin, Pei-Pei Xie, Zhenya Dai, Shuo-qing Zhang, Pu-Sheng Wang, Yu-Gen Chen, Tian-Ci Wang, Xin Hong, L. Gong   +8 more
semanticscholar   +1 more source

NiH-Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3 )-H Alkylation of Alkenes.

Angewandte Chemie, 2018
The terminal-selective, remote C(sp3 )-H alkylation of alkenes was achieved by a relay process combining NiH-catalyzed hydrometalation, chain walking, and alkylation.
F. Zhou, Jin Zhu, Yao-Wei Zhang, Shaolin Zhu   +3 more
semanticscholar   +1 more source

Rh(III)-Catalyzed Redox-Neutral Unsymmetrical C-H Alkylation and Amidation Reactions of N-Phenoxyacetamides.

Journal of the American Chemical Society, 2018
A Rh(III)-catalyzed unsymmetrical C-H alkylation and amidation of N-phenoxyacetamides with diazo compounds has been developed under mild and redox-neutral conditions, producing dinitrogen as the only byproduct.
Yunxiang Wu, Zhaoqiang Chen, Yaxi Yang, Weiliang Zhu, Bing Zhou   +4 more
semanticscholar   +1 more source

Alkylated steroids from tosylhydrazones and alkyl-lithiums

Journal of the Chemical Society C: Organic, 1971
The reaction between 5α-cholestan-3-one tosylhydrazone and alkyl-lithium reagents produces equatorial 3β-alkyl-5α-cholestanes.
Ciria Valencia Ortiz, Josef E. Herz
openaire   +3 more sources

Alkylation of tricarbonylcyclohexadienyliron salts () with lithium alkyls

Tetrahedron Letters, 1980
Abstract The salts 1 (Y=H, OMe, Me) react with RLi(R=Me, n-Bu, i-Pr, t-Bu) in CH2Cl2 at low temperature to give 2 and 3 in excellent yields. Nucleophilic addition at the 1-position of 1 (Y=OMe) has been observed for the first time.
B. M. Ratnayake Bandara, Thong-Chak Khor, Arthur J. Birch   +2 more
openaire   +2 more sources

Sequence-Dependent Stereodivergent Allylic Alkylation/Fluorination Reaction of Acyclic Ketones.

Angewandte Chemie, 2019
The stereodivergent Ir-catalyzed allylic alkylation and fluorination of acyclic ketones is described. α -Pyridyl- α -fluoroketones with vicinal tertiary and quaternary stereocenters were obtained in moderate to excellent yields and stereoselectivities ...
Xi‐Jia Liu, Shicheng Jin, Wen‐Yun Zhang, Qiang-qiang Liu, C. Zheng, S. You   +5 more
semanticscholar   +1 more source

Reductive alkyl–alkyl coupling from isolable nickel–alkyl complexes

Nature
The selective cross-coupling of two alkyl electrophiles to construct complex molecules remains a challenge in organic synthesis1,2. Known reactions are optimized for specific electrophiles and are not amenable to interchangeably varying electrophilic substrates that are sourced from common alkyl building blocks, such as amines, carboxylic acids and ...
Samir Al Zubaydi, Shivam Waske, Volkan Akyildiz, Hunter F. Starbuck, Mayukh Majumder, Curtis E. Moore, Dipannita Kalyani, Christo S. Sevov   +7 more
openaire   +3 more sources