Results 121 to 130 of about 68,808 (283)
Innovation of Chemistry & Materials for SustainabilityThe hydrosilylation reaction plays a key role in organosilicon chemistry, enabling the formation of silicon-carbon bonds crucial for industrial and specialty chemical production.
Kazu Okumura +4 more
doaj +1 more source
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing
Advanced Science, EarlyView.A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi +8 more
wiley +1 more source
Synthesis of Tungsten Complexes Containing an Intramolecularly Coordinated Alkyne Group
, 2016 Irradiation of cyclopentadienyltungsten carbonyl complexes bearing a pendant alkyne group promoted intramolecular displacement of CO by the alkyne. The resulting complexes, which contain an intramolecularly coordinated alkyne group, were characterized ...
Murray V. Baker (1589071) +1 more
core +1 more source
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging
MoleculesFluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza +10 more
doaj +1 more source
Porphyrin‐Based Porous Materials for Antibacterial Applications
Advanced Science, EarlyView.Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang +4 more
wiley +1 more source
UNDERSTANDING GOLD‐ALKYNE ACTIVATION FROM BOND DISSOCIATION ENERGIES OF GOLD‐ALKYNE COMPLEXES
International audienceA detailed approach into electronic effects of ligands on gold‐alkyne interactions has been carried out in the gas phase using tandem mass spectrometry.
Gimbert, Yves +5 more
core +1 more source
An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence
Advanced Science, EarlyView.A supramolecular electrochemiluminescent (ECL) system is presented in which cucurbit[7]uril (CB7) is covalently linked to [Ru(bpy)3]2+, forming a recognition‐responsive emitter. Host‒guest preorganization of tri‐n‐propylamine enables intramolecular ECL, boosting intensity by 162% compared to the standard system.
Maria Vittoria Balli +7 more
wiley +1 more source