Results 221 to 230 of about 66,858 (295)

Modular Access to α‐Tertiary Amines: Electrochemical Tandem Di‐Functionalization of Olefins With Ammonia Surrogates and Amino Acids

open access: yesAngewandte Chemie, EarlyView.
A metal‐ and oxidant‐free electrochemical multicomponent di‐functionalization strategy that rapidly converts 1,1‐disubstituted alkenes into α‐tertiary primary amines with simultaneous installation of bio‐relevant sulfur or selenium motifs was devised for late‐stage functionalization. ABSTRACT Quaternary carbon centers, especially those bearing nitrogen,
Adrija Ghosh   +4 more
wiley   +1 more source

Force‐Induced Control of Circularly Polarized Luminescence With Rotaxane Architecture

open access: yesAngewandte Chemie, EarlyView.
Force‐induced reversible on/off switching of circularly polarized luminescence is achieved with a rotaxane‐based supramolecular mechanophore. The mechanophore, featuring a chiral helicene luminophore, is incorporated as a first network cross‐linker into a double‐network organogel.
Keigo Nonaka   +10 more
wiley   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

open access: yesAngewandte Chemie, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran   +5 more
wiley   +1 more source

Unified Synthesis of Unconventional α‐Polyhalogenated Amines Through Hydroaminoalkylation

open access: yesAngewandte Chemie International Edition, EarlyView.
A unified, redox‐neutral method that transforms alkenes and alkynes into α‐polyhalomethyl amines using stable hemiaminal reagents is reported. This approach enables access to CF3, CF2H, CF2Cl, and CFClH motifs, expanding halogenated amine space with broad substrate scope, functional group tolerance, and applicability to late‐stage modification of drug ...
Angela K. Hofmeister   +9 more
wiley   +1 more source

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