Results 111 to 120 of about 82,660 (245)

Role of mitochondrial uncoupling protein-4 in energy supply during neuronal differentiation [PDF]

, 2011
OBJECTIVES: Neuronal differentiation is involved in brain development. Stimulation of all-trans-retinoic acid (RA) in neuroblastoma cells results in growth inhibition, increased neuron-specific enolase (NSE) activity, and promoted axonal growth ...
Chan, KH, Ho, JWM, Ho, PWL, Ho, SL, Liu, H, Ramsden, DB, So, DHF   +6 more
core  

Metabolism of all-trans-retinoic acid by cultured human epidermal keratinocytes

Journal of Lipid Research, 1997
The uptake and metabolism of exogenous all-trans-retinoic acid by human epidermal keratinocytes in submerged culture was examined. Retinoic acid presented to keratinocytes in physiological form bound to albumin was rapidly taken up.
R K Randolph, M Simon
doaj   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Effects of all Trans Retinoic Acid Combined with Cisplatin on Survival of Gastric Cancer Cell Line (AGS)

پزشکی بالینی ابن سینا, 2013
Introduction & Objective: All-trans retinoic acid, a derivative of retinoids, is widely used to in-duce prolifferation, differentiation and apoptosis in normal, precancareous and cancerous cells. Cisplatin, an effective drug for cancer treatment, induces
Noruz Najafzadeh, Asadollah Abbasi, Mohammad Mazani, Mojtaba Amani   +3 more
doaj  

All-trans Retinoic Acid Induced the Differentiation of Human Glioma Cells

Cancer Biology & Medicine, 2011
OBJECTIVE To observe the effect of all-trans retinoic acid (ATRA) on inducing human glioma MO59K cells differentiation and further explore the underlying molecular mechanisms.METHODS The expression of glial fibrillary acidic protein (GFAP) was ...
Qing-xi Liu, Nan Wang, Xing-hua Liao, Guang-da Ren, Tao Qin, Ru-fa Yu, Cai-lian Cheng   +6 more
doaj   +1 more source

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. [PDF]

, 2009
The innate immune response of airway epithelial cells to airborne allergens initiates the development of T cell responses that are central to allergic inflammation.
Angkasekwinai, Pornpimon, Barranco, Wade T, Corry, David B, Dong, Chen, Goswami, Sangeeta, Greenlee, Kendra J, Kheradmand, Farrah, Polikepahad, Sumanth, Redding, David, Seryshev, Alexander, Shan, Ming, Singh, Bhupinder, Song, Li-zhen, Sur, Sanjiv, Woodruff, Prescott   +14 more
core  

Targeting the Menin–KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation

European Journal of Haematology, EarlyView.
ABSTRACT Acute leukemias characterized by a shared epigenetic dependency on the menin–KMT2A axis rely on aberrant HOX‐driven transcriptional programs that sustain leukemic self‐renewal and impair differentiation. This dependency is most evident in KMT2A‐rearranged and NPM1‐mutated acute myeloid leukemia (AML), but also extends to other HOX‐dependent ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Mamdouh Skafi, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Self-assembled aldehyde dehydrogenase-activatable nano-prodrug for cancer stem cell-enriched tumor detection and treatment

Nature Communications
Cancer stem cells, characterized by high tumorigenicity and drug-resistance, are often responsible for tumor progression and metastasis. Aldehyde dehydrogenases, often overexpressed in cancer stem cells enriched tumors, present a potential target for ...
Bowen Li, Jianwu Tian, Fu Zhang, Chongzhi Wu, Zhiyao Li, Dandan Wang, Jiahao Zhuang, Siqin Chen, Wentao Song, Yufu Tang, Yuan Ping, Bin Liu   +11 more
doaj   +1 more source

A case of acute promyelocytic leukemia with morphologic multilineage dysplastic changes

Hematology Reports, 2013
Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS ...
Setsuki Isono, Katsuyasu Saigo, Keiko Nagata, Keiko Numata, Toshiaki Kojitani, Akiharu Okamura, Akihiko Nishizawa, Masafumi Takata, Mariko Takenokuchi, Eiji Tatsumi   +9 more
doaj   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source