Results 111 to 120 of about 18,841,230 (238)

Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation

The role of specific human cytochrome P450 (CYP) isoforms in the oxidative metabolism of all-trans-retinoic acid was investigated by studies in human liver microsomes using isoform-specific chemical inhibitors and inhibitory antibodies.
Daly AK, McSorley LC
core   +4 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, Volume 20, Issue 11, Page 2569-2583, November 2026.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Acute Promyelocytic Leukemia With PML‐RARA Rearrangement: Clinical and Morphologic Features

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Recognition of the characteristic morphologic features of acute promyelocytic leukemia on peripheral blood smear should prompt immediate initiation of all‐trans retinoic acid while awaiting confirmatory testing, as early intervention is critical to reducing hemorrhagic mortality and improving clinical outcomes.
Chukwuka Elendu, Ayodeji D. Johnson, Ayi T. Debua   +2 more
wiley   +1 more source

Supplementing With the Vitamin A Metabolite Retinoic Acid Can Alleviate Negative Affective States Caused by SPI1‐Induced Immune and Metabolic Dysfunctions Following Intestinal Barrier Impairment

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Ulcerative colitis (UC) and depression (DP) are significant comorbidities in epidemiological research. However, the mechanisms underlying UC‐induced DP remain poorly understood. Myeloid differentiation and retinoic acid metabolic dysregulation are implicated in both conditions, yet their interconnection in the context of comorbidity is unclear.
Yang Feng, Pai Xie, Ni‐ren Li, Yi‐xuan Zeng, Bing‐ying Deng, Yu‐feng Gu, Si‐fan Lu, Yi Liu   +7 more
wiley   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Engineering In Vitro Models of Skeletal Muscle With Neuromuscular Junctions Using Hierarchical Micro‐Nano Biomaterials: Cooperative Effect of Adhesion Ligand Nanoclustering and Surface Anisotropy

Small, Volume 22, Issue 62, 6 November 2026.
This study investigates the cooperative effects of adhesive ligand distribution, density, and biomaterial morphology for innervated skeletal muscle tissue engineering. Ligand nanoclusters were created in aligned micropatterns by electrospinning of a RAFT‐synthesized polymer with controlled ligand presentation.
Shirin Nour, Kristy Swiderski, Sahar Salehi, Gordon S. Lynch, Andrea J. O'Connor, Greg G. Qiao, Daniel E. Heath   +6 more
wiley   +1 more source

Optimizing the Treatment of Acute Promyelocytic Leukemia: A Maintenance-Free Strategy for Complete Remission

Haematology Journal of Bangladesh
Background: Acute promyelocytic leukaemia (APL) is a distinct variant of acute myeloid leukaemia (AML), comprising 5-10% of all AML cases. Characterized by the t(15; 17) chromosomal translocation, APL presents a unique challenge due to its associated ...
Muhammad Kamruzzaman, Sanghita Banik Proma, Mohit Kumar Pramanik, Marzia Afrin, Md. Sirajul Islam   +4 more
doaj   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, Volume 41, Issue 11, Page 1188-1200, November 2026.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

All-trans retinoic acid modulates microvascular endothelial cell hemostatic properties

Haematologica, 2003
BACKGROUND AND OBJECTIVES: All-trans retinoic acid (ATRA) is an anti-tumor agent capable of controlling the hypercoagulable state associated with malignancy.
M Marchetti, A Vignoli, MR Bani, D Balducci, T Barbui, A Falanga   +5 more
doaj  

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source