Results 121 to 130 of about 18,841,230 (238)

Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

European Journal of Haematology, Volume 117, Issue 5, Page 1258-1264, November 2026.
ABSTRACT Objective This study aimed to evaluate the feasibility and safety of venetoclax as a cytoreductive strategy during induction therapy in newly diagnosed acute promyelocytic leukemia (APL), and to provide an exploratory description of its early efficacy.
Yu Wang, Rong Xiao, Xiaobing Huang, Yi Xiao   +3 more
wiley   +1 more source

Two Cases of Intracranial Hypertension Associated with All-Trans Retinoic Acid Therapy for Acute Promyelocytic Leukemia

, 1999
To review the literature and report two cases of intracranial hypertension associated with all- trans retinoic acid (ATRA) treatment in children with acute promyelocytic leukemia (APL)
Femida Kherani, MD; J. Lewis, MD; G. Drummond, MD
core  

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Differences in metabolism and isomerization of all-trans-retinoic acid and 9-cis-retinoic acid between human endothelial cells and hepatocytes

, 1997
Retinoic acid stimulates the expression of tissue-type plasminogen activator (t-PA) in vascular endothelial cells in vitro and enhances t-PA levels in plasma and tissues in vivo.
Kooistra, T., Lansink, M., Bennekum, A.M. van, Blaner, W.S.   +3 more
core  

Photoisomerization of retinoic acid and its influence on regulation of human keratinocyte growth and differentiation

, 2000
71-76Retinoic acid constantly undergoes structural inter-conversions among the geometrical isomers (all-trans-retinoic acid, 9-cis- retinoic acid, 11-cis-retinoic acid , 13-cis- retinoic acid and 9-13-di-cis-retinoic acid) by photoisomerization under ...
Suzuki, Takakaju, Kunchala, Sridhar Rao, Murayama, Akira   +2 more
core  

All-trans retinoic acid

, 2000
12th Mediterranean Congress of Chemotherapy -- NOV 11-14, 2000 -- MARRAKECH, MOROCCOThe introduction of all-trans retinoic acid (ATRA) has further changed the manage-ment of acute promyelocytic leukemia (APL). After using of ATRA, the rate of early death
Tiftik, N, Aybak, M, Ayyildiz, O, Müftüoglu, E   +3 more
core  

Embryonic subcellular distribution of 13-cis- and all-trans-retinoic acid indicates differential cytosolic/nuclear localization

, 2001
Isotretinoin (13-cis-retinoic acid [13CRA], Accutane®) is used for the treatment of dermatological diseases. Isotretinoin is, however, teratogenic in animals and humans. The mechanism of action of its teratogenicity is still not clearly identified.
Rühl, Ralph, Plum, Claudi, Nau, Heinz, Elmazar, Mohamed M.   +3 more
core   +1 more source

Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid. [PDF]

Invest Ophthalmol Vis Sci
Zhan B, Wang X, Chen Z, Li M, Ten W, Wang Y, Huang Y, Zhou X.   +7 more
europepmc   +1 more source

All-Trans Retinoic Acid Nanocrystals for Enhanced Anticancer Activity Against Neuroblastoma Cancer Stem Cells. [PDF]

Pharmaceutics
Ajmeera D, Ajumeera R.
europepmc   +1 more source

Leukemia cutis and all-trans retinoic acid-induced myocarditis in acute promyelocytic leukemia. [PDF]

Clin Hematol Int
Rahbari KJ, Patel PC, Profitt S, Kelley JT, O'Connell KA, Dewan AK, Kennedy KE, Mittlebeeler EE, Kishtagari A, Ball S, Mohan SR, Fedorov K.   +11 more
europepmc   +1 more source