Results 191 to 200 of about 18,841,230 (238)

Retinoic Acid Syndrome Subsequent to the First Dose of All Trans Retinoic Acid

The Journal of Emergency Medicine, 2008
[Abstract Not Available]
Altintas, Abdullah, Pasa, Semir, Cil, Timucin, Kaplan, M. Ali, Ayyildiz, Orhan   +4 more
openaire   +1 more source

Colorimetric determination of all-trans-retinoic acid and 13-cis-retinoic acid

Analytical Biochemistry, 1978
Abstract A method employing trifluoroacetic acid for the quantitative determination of all- trans -retinoic acid and 13- cis -retinoic acid in serum is described. The method permits the detection of as little as 0.3 μg of either compound.
C C, Wang, R E, Hodges, D L, Hill
openaire   +2 more sources

Radiologic Features of All-Trans-Retinoic Acid Syndrome

American Journal of Roentgenology, 2002
The treatment of acute promyelocytic leukemia with all-trans-retinoic acid (ATRA) sometimes results in a syndrome characterized by fever, respiratory distress, weight gain, pleural and pericardial effusion, and pulmonary infiltrates. We report the radiologic features of ATRA syndrome.During the past 5 years, 69 patients with acute promyelocytic ...
Jung Im, Jung, Jung Eun, Choi, Seong Tai, Hahn, Chang Ki, Min, Chun Choo, Kim, Seog Hee, Park   +5 more
openaire   +2 more sources

Glucuronidation of all-trans-retinoic acid in liposomal membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1993
Retinoyl beta-D-glucuronide is a biologically active metabolite of retinoic acid. The kinetics of UDP-glucuronosyltransferase-catalyzed biosynthesis of retinoyl beta-D-glucuronide was examined in rat liver and intestinal native microsomes incubated with [3H retinoic acid incorporated into liposomes.
K L, Salyers, M E, Cullum, M H, Zile
openaire   +2 more sources

Variability in the Oral Bioavailability of All-trans-Retinoic Acid

JNCI Journal of the National Cancer Institute, 1993
Orally administered all-trans-retinoic acid (all-trans-RA) can induce complete remission in a high proportion of patients with acute promyelocytic leukemia. A previous pharmacokinetic study in patients with acute promyelocytic leukemia raised the possibility that the absorption of orally administered all-trans-RA is a saturable process that would have ...
P C, Adamson, H C, Pitot, F M, Balis, J, Rubin, R F, Murphy, D G, Poplack   +5 more
openaire   +2 more sources

All-trans retinoic acid in acute promyelocytic leukaemia

Best Practice & Research Clinical Haematology, 2003
The vitamin A derivative, all-trans retinoic acid (ATRA), induces differentiation of leukaemic promyelocytes in patients with acute promyelocytic leukaemia (APL). As a result, the majority of patients achieve complete remission either with ATRA alone or with combined ATRA and chemotherapy.
Giuseppe, Avvisati, Martin S, Tallman
openaire   +2 more sources

Biliary metabolites of all-trans-retinoic acid in the rat

Archives of Biochemistry and Biophysics, 1983
Biliary metabolites from physiological doses of all-trans-[10-3H]retinoic acid were examined in normal and vitamin A-deficient rats. The bile from normal and vitamin A-deficient rats contained approximately 60% of the administered dose following a 24-h collection period.
K L, Skare, H F, DeLuca
openaire   +2 more sources

Dose-Dependent Pharmacokinetics of All-trans-Retinoic Acid

JNCI Journal of the National Cancer Institute, 1992
Orally administered all-trans-retinoic acid (all-trans-RA) can induce remission in a high proportion of patients with acute promyelocytic leukemia.To further define the drug's pharmacokinetics, a study of intravenous all-trans-RA was performed in rhesus monkeys.A total of nine monkeys received intravenous bolus injections of all-trans-RA.
P C, Adamson, F M, Balis, M A, Smith, R F, Murphy, K A, Godwin, D G, Poplack   +5 more
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Have all-trans retinoic acid and arsenic trioxide replaced all-trans retinoic acid and anthracyclines in APL as standard of care

Best Practice & Research Clinical Haematology, 2014
Until recently, the standard of care in the treatment of APL has involved the combination of all-trans retinoic acid with anthracycline-based chemotherapy during both induction and consolidation. Additionally, the intensity of consolidation chemotherapy has evolved according to a universally accepted relapse-risk stratification algorithm based on the ...
Harry J, Iland, Andrew, Wei, John F, Seymour   +2 more
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All-trans-retinoic acid-induced myositis: A description of two patients

American Journal of Hematology, 2000
All-trans-retinoic acid (ATRA) induces complete clinical remissions in a high proportion of patients with acute promyelocytic leukemia and has become the standard induction therapy. Its use as a single agent results in short-lived remissions; thus, cytotoxic drugs are used for "consolidation" therapy.
van Der Vliet, H J, Roberson, A E, Hogan, M C, Morales, C E, Crader, S C, Letendre, L, Pruthi, R K   +6 more
openaire   +4 more sources