Results 201 to 210 of about 82,660 (245)

Radiologic Features of All-Trans-Retinoic Acid Syndrome

American Journal of Roentgenology, 2002
The treatment of acute promyelocytic leukemia with all-trans-retinoic acid (ATRA) sometimes results in a syndrome characterized by fever, respiratory distress, weight gain, pleural and pericardial effusion, and pulmonary infiltrates. We report the radiologic features of ATRA syndrome.During the past 5 years, 69 patients with acute promyelocytic ...
Jung Im, Jung, Jung Eun, Choi, Seong Tai, Hahn, Chang Ki, Min, Chun Choo, Kim, Seog Hee, Park   +5 more
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All-trans retinoic acid in acute promyelocytic leukaemia

Best Practice & Research Clinical Haematology, 2003
The vitamin A derivative, all-trans retinoic acid (ATRA), induces differentiation of leukaemic promyelocytes in patients with acute promyelocytic leukaemia (APL). As a result, the majority of patients achieve complete remission either with ATRA alone or with combined ATRA and chemotherapy.
Giuseppe, Avvisati, Martin S, Tallman
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All trans retinoic acid enhances human LAK activity

European Journal of Haematology, 1995
Abstract: All trans retinoic acid has various effects on normal and malignant cells. Lymphokine‐activated killer (LAK) activity can be derived from T lymphocytes and natural killer cells. This study shows that all trans retinoic acid significantly enhances this activity by increasing production of tumour necrosis factor and gamma interferon, which ...
C, Fegan, R, Bailey-Wood, S, Coleman, S A, Phillips, L, Neale, T, Hoy, J A, Whittaker   +6 more
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Dose-Dependent Pharmacokinetics of All-trans-Retinoic Acid

JNCI Journal of the National Cancer Institute, 1992
Orally administered all-trans-retinoic acid (all-trans-RA) can induce remission in a high proportion of patients with acute promyelocytic leukemia.To further define the drug's pharmacokinetics, a study of intravenous all-trans-RA was performed in rhesus monkeys.A total of nine monkeys received intravenous bolus injections of all-trans-RA.
P C, Adamson, F M, Balis, M A, Smith, R F, Murphy, K A, Godwin, D G, Poplack   +5 more
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Modulation of all-trans retinoic acid pharmacokinetics by liarozole

Cancer Chemotherapy and Pharmacology, 1994
Continuous oral dosing with all-trans retinoic acid (RA) is associated with a progressive decrease in plasma drug concentrations that has been linked to relapse and retinoid resistance in patients with acute promyelocytic leukemia (APL). Since oxidation by cytochrome P-450 enzymes is critical in the catabolism of this drug, we evaluated whether ...
V A, Miller, J R, Rigas, J R, Muindi, W P, Tong, E, Venkatraman, M G, Kris, R P, Warrell   +6 more
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Nuclear all-trans retinoic acid receptors

Biological Trace Element Research, 1998
The present study was undertaken to investigate the effects of selenite (SeIV) and selenate (SeVI) on the all-trans retinoic acid (RA)-nuclear retinoic acid receptor (RAR) complex formation in rat liver. We also present the data on the in vitro effects of SeIV on the RARalpha and the type I iodothyronine 5'-deiodinase gene expression in the GH4C1 rat ...
J, Brtko, P, Filipcík, S, Hudecová, A, Brtková, J, Bransová   +4 more
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All-trans-retinoic acid-induced myositis: A description of two patients

American Journal of Hematology, 2000
All-trans-retinoic acid (ATRA) induces complete clinical remissions in a high proportion of patients with acute promyelocytic leukemia and has become the standard induction therapy. Its use as a single agent results in short-lived remissions; thus, cytotoxic drugs are used for "consolidation" therapy.
van Der Vliet, H J, Roberson, A E, Hogan, M C, Morales, C E, Crader, S C, Letendre, L, Pruthi, R K   +6 more
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Retinoic Acid Syndrome Subsequent to the First Dose of All Trans Retinoic Acid

The Journal of Emergency Medicine, 2008
[Abstract Not Available]
Altintas, Abdullah, Pasa, Semir, Cil, Timucin, Kaplan, M. Ali, Ayyildiz, Orhan   +4 more
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All-trans retinoic acid beyond acute promyelocytic leukemia

Cancer Cell
All-trans retinoic acid (ATRA), a known regulator of hematopoiesis, is a key component of the established therapeutic regimen for treating acute promyelocytic leukemia (APL). In this issue of Cancer Cell, Mosialou et al. present a niche-based mechanism of ATRA targeting osteoblasts, repurposing ATRA treatment beyond APL.
Usama-Ur, Rehman, Michael, Lübbert
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All trans retinoic acid.

The Journal of the Association of Physicians of India, 1996
ATRA is extremely effective for inducing clinical remission in APML. The presence of PML/RAR-alpha fusion gene produced as a result of the unique chromosomal translocation in APML is a marker of the sensitivity to ATRA therapy. Further research is needed to elucidate the mechanisms by which the development of the fusion protein in APML leads to the ...
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