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Retinoic Acid, All-trans Retinoic Acid (ATRA), and Tamibarotene
2017Retinoids, all-trans retinoic acid (ATRA), and tamibarotene can induce differentiation of leukemic cells that carry t(15;17) and potentially lead to complete remission (CR) in patients with acute promyelocytic leukemia (APL). Although introduction of ATRA as a differentiating agent has been a major breakthrough in the treatment of APL, ATRA is ...
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Retinoids (13-Cis-Retinoic Acid, Isotretinoin, Accutane, All-Trans-Retinoic Acid)
2015Isotretinoin is a synthetic form of vitamin A that has been used in the United States since 1983 mainly for the treatment of severe cystic acne. Long-term therapy with low-dose isotretinoin has also been used for prevention of basal cell carcinoma and treatment of cutaneous T-cell lymphomas, and all-trans-retinoic acid (ATRA) has been used in patients ...
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Glucuronidation of all-trans-retinoic acid in liposomal membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1993Retinoyl beta-D-glucuronide is a biologically active metabolite of retinoic acid. The kinetics of UDP-glucuronosyltransferase-catalyzed biosynthesis of retinoyl beta-D-glucuronide was examined in rat liver and intestinal native microsomes incubated with [3H retinoic acid incorporated into liposomes.
K L, Salyers, M E, Cullum, M H, Zile
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All-Trans-Retinoic Acid (ATRA): Pediatric Acute Promyelocytic Leukemia
Pediatric Hematology and Oncology, 1998Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloblastic leukemia (AML). In this report, we present the clinical features, management, and outcome of pediatric patients with APL treated with all-trans-retinoic acid (ATRA). Of 52 newly diagnosed cases of APL between February 1992 and December 1996, 15 were in the pediatric age ...
A, Bapna +6 more
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[All-trans retinoic acid (Tretinoin)].
Gan to kagaku ryoho. Cancer & chemotherapy, 1997Differentiation therapy with all-trans retinoic acid (ATRA, tretinoin) alone or in combination with chemotherapy induces around 90% complete remission in acute promyelocytic leukemia (APL). By giving non-cross resistant chemotherapy as postremission therapy, more than 50% of APL, especially more than 70% of APL patients of age less than 30, became ...
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Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid
Anti-Cancer Drugs, 2001We report the first case of granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid (ATRA) in a patient with acute promyelocytic leukemia (APL). Acute renal failure during treatment with ATRA has been previously reported as a part of an ATRA syndrome or a thrombotic complication of a hypercoagulable state.
N, Tomita +9 more
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Tretinoin (all-trans-Retinoic Acid, Vitamin A Acid)
1993Vitamin A and its derivatives have been known for over 40 years to influence keratinization and epithelial differentiation. In 1962, Stuttgen in Dusseldorf and Beer in Basel independently demonstrated the efficacy of topical tretinoin (retinoic acid, vitamin A acid) in various neoplasms of the skin and chronic hyperkeratotic disorders, especially ...
Gerd Plewig, Albert M. Kligman
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The introduction of all-trans retinoic acid (ATRA) has further changed the manage-ment of acute promyelocytic leukemia (APL). After using of ATRA, the rate of early death and relapse has decreased dramatically. From February 1997 to March 2000, 12 consecutive patients with APL were treated with ATRA at an oral dose of 45mg/m(2)/d alone or in ...
Ayyildiz, O +3 more
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Ayyildiz, O +3 more
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All‐trans retinoic acid toxicity
European Journal of Haematology, 1992K.G. van der Hem, G.J. Ossenkoppele
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Clinical pharmacology of all-trans retinoic acid.
Leukemia, 1994The clinical pharmacology of all-trans retinoic acid (RA) has distinct differences from that of its widely studied stereoisomer 13-cis retinoic acid (cRA). RA is much more rapidly cleared from plasma following oral administration; their respective half-lives are < 1 h and 13 h.
J R, Muindi, C W, Young, R P, Warrell
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