Results 81 to 90 of about 82,660 (245)

Neuronal differentiation and tissue engineering strategies for central neurous system injury repair

BMEMat, EarlyView.
This review outlines tissue engineering advances for central nervous system (CNS) injury treatment, focusing on three core components: seed cells, inductive factors, and scaffold materials, with evaluation of their respective strengths and limitations. Tissue engineering for CNS injury repair.
Zhuqing Xia, Jinghui Zhang, Na Ren, Shuping Wang, Congcong Zhang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Chao Liu, Chunhui Sun, Jingang Wang   +9 more
wiley   +1 more source

The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development [PDF]

, 1998
Hox11 is a homeobox gene essential for spleen formation in mice, since atrophy of the anlage of a developing spleen occurs in early embryonic development in Hox11 null mice.
Greene, W.K., Bahn, S., Masson, N., Rabbitts, T.H.   +3 more
core   +2 more sources

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Predictive role of vitamin A serum concentration in psoriatic patients treated with IL-17 inhibitors to prevent skin and systemic fungal infections

Journal of Pharmacological Sciences, 2020
The use of biological drugs in psoriasis is replacing traditional therapies due to their specific mechanism and limited side effects. However, the use of Interleukin 17 inhibitors and the modification of its cytokine pathway could favor the risk of ...
Campione Elena, Cosio Terenzio, Lanna Caterina, Mazzilli Sara, Ventura Alessandra, Dika Emi, Gaziano Roberta, Dattola Annunziata, Candi Eleonora, Bianchi Luca   +9 more
doaj   +1 more source

The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells [PDF]

, 2018
Background: Tumorigenesis is driven by stem cell (SC) overpopulation. BecauseALDH is both a marker for SCs in many tissues and a key enzyme in retinoid acid (RA)signaling, we studied RA signaling in normal and malignant colonic SCs.Hypothesis: RA ...
Boman, Bruce M., Fields, Jeremy Z., Gupta, Anindita, Kowash, Ryan, Masters, Gabriel, Modarai, Shirin R., Opdenaker, Lynn M., Viswanathan, Vignesh, Zhang, Tao   +8 more
core   +1 more source

All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A. [PDF]

, 2016
Patients with type 1 diabetes mellitus are associated with impairment in vitamin A metabolism. This study evaluated whether treatment with retinoic acid, the biologically active metabolite of vitamin A, can ameliorate diabetes.
Chang, Fang-Pei, Chien, Chiao-Yun, Cho, Candy Hsin-Hua, Lee, Hsuan-Shu, Mao, Wan-Yu, Shen, Chia-Ning, Wu, Ruei-Ren, Yuan, Tze-An   +7 more
core   +2 more sources

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

The Effect of All-Trans Retinoic Acid Supplementation to Periodontitis

LINK, 2015
Vitamin A metabolite all-trans retinoic acid (ATRA), regulates periodontal collagen synthesis. Type 1 collagen, main component of periodontium was destroyed in perio-dontitis.
Praptiwi Hanafi, Enik Sulistyowati, Kustiono Kustiono   +2 more
doaj   +1 more source

Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group

Haematologica, 2018
In standard-risk acute promyelocytic leukemia, recent results have shown that all-trans retinoic acid plus arsenic trioxide combinations are at least as effective as classical all-trans retinoic acid plus anthracycline-based chemotherapy while being less
Lionel Adès, Xavier Thomas, Agnes Guerci Bresler, Emmanuel Raffoux, Olivier Spertini, Norbert Vey, Tony Marchand, Christian Récher, Arnaud Pigneux, Stephane Girault, Eric Deconinck, Claude Gardin, Olivier Tournilhac, Jean Francois Lambert, Patrice Chevallier, Stephane de Botton, Julie Lejeune, Hervé Dombret, Sylvie Chevret, Pierre Fenaux   +19 more
doaj   +1 more source