Results 61 to 70 of about 18,841,230 (238)

Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells

Journal of Lipid Research, 2004
An acidic phospholipase A2 (LPLA2) was recently purified and cloned. THP-1 cells were used to characterize the gene induction of LPLA2. THP-1 cells were stimulated with several differentiation agents.
Akira Abe, Heather K. Poucher, Miki Hiraoka, James A. Shayman   +3 more
doaj   +1 more source

RNA‐Binding Proteins Shape Mammalian Retroelement RNA Fate: Lessons From HIV‐1, LINE‐1, and Related Reverse‐Transcribing Elements

Animal Research and One Health, EarlyView.
RNA‐binding proteins (RBPs) and RNA‐associated factors shape retroelement RNA fate by regulating RNA processing, translation, RNP assembly and remodeling, reverse transcription, nuclear trafficking, chromatin engagement, and RNA surveillance. These pathways balance productive retroviral replication or retrotransposon insertion with RNA decay ...
Mingrui Li, Zhangyuan Pan, Yongjuan Guan
wiley   +1 more source

Supplementary Figure 3 from All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin Carcinogenesis

, 2009
Supplementary Figure 3 from All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin ...
Jennica Stein (15092659), Heather E. Kleiner (15092665), Satish B. Cheepala (15092653), Zanobia Syed (659360), Jennifer N. Gill (15092656), Cherie Ann Nathan (14905386), Patrick Adegboyega (5946032), John L. Clifford (15090888), Vinita Batra (15092662), John DiGiovanni (225702)   +9 more
core   +1 more source

Old data, new tricks: Comprehensive computational analysis of 10 years of multi‐center EuroFlow acute myeloid leukemia diagnostic immunophenotypic data

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute myeloid leukemia (AML) is characterized by high genotypic and immunophenotypic heterogeneity. We collected an extensive dataset containing 5366 flow cytometry files from 885 AML patients, stained with the EuroFlow acute leukemia orientation tube (ALOT) and AML/MDS panel, acquired in a standardized way at eight centers over a period of 10 
Sarah Bonte, Rosan Olsman, Sofie Van Gassen, Sergio Matarraz, Neus Villamor, Stefan Nierkens, Paula Fernandez, Elaine Sobral da Costa, Carmen‐Mariana Aanei, Alberto Orfao, Jacques J. M. van Dongen, Yvan Saeys, Mattias Hofmans, Vincent H. J. van der Velden   +13 more
wiley   +1 more source

Supplementary Figure 2 from All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin Carcinogenesis

, 2009
Supplementary Figure 2 from All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin ...
Jennica Stein (15092659), Heather E. Kleiner (15092665), Satish B. Cheepala (15092653), Zanobia Syed (659360), Jennifer N. Gill (15092656), Cherie Ann Nathan (14905386), Patrick Adegboyega (5946032), John L. Clifford (15090888), Vinita Batra (15092662), John DiGiovanni (225702)   +9 more
core   +1 more source

A single base‐pair variation in a limb‐specific Lhx9 cis‐regulatory region modulates HAND2‐associated posterior repression

Developmental Dynamics, EarlyView.
Abstract LIM Homeobox 9 (Lhx9) is a transcription factor involved in vertebrate limb development. Despite conserved anterior expression, its distal expression is species‐specific. In chickens, distal expression is restricted to the anterior mesoderm; in mice, it extends into posterior mesoderm.
Jeanyoung Kim, Grace Santrach, William M. Sparks, Molly Ahola, Jessica C. Britton, Novalee Erickson, Shimako Kawauchi, Eunyoung Kim, Charmaine U. Pira, Kerby C. Oberg   +9 more
wiley   +1 more source

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes

Haematologica, 2019
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1 ...
Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad   +19 more
doaj   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Isotretinoin and Adolescent Growth: A Systematic Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Despite widespread use as an effective systemic therapy for adolescent acne, the effects of isotretinoin on pediatric skeletal development remain a subject of debate in the medical literature. Evidence characterizing its potential influence on growth plate maturation and skeletal outcomes is limited.
Valentina Caicedo, Jennifer Keelin, Siddharth Jasti, Yasmine Mohseni, Devon Foster, Alexander Daoud   +5 more
wiley   +1 more source