Allantoin ameliorated liver fibrosis in a mouse model of non-alcoholic steatohepatitis: role of nuclear factor kappa B/cyclooxygenase 2/prostaglandin E2 pathway [PDF]
Journal of HerbMed Pharmacology, 2022 Introduction: Non-alcoholic steatohepatitis (NASH) is considered as current and critical liver disease and liver fibrosis is an initial step to vast NASH injuries. Allantoin is an important and sure composite, which has remark effects on inflammation and
Tahereh Komeili-Movahhed, Azam Moslehi
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Antioxidants, 2022 Allantoin is crucial for plant growth and development as well as adaptations to abiotic stresses, but the underlying molecular mechanisms remain unclear.
Juan Wang +10 more
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Scientific Reports, 2023 Allantoin is a good source of ammonium for many organisms, and in Escherichia coli it is utilized under anaerobic conditions. We provide evidence that allantoinase (AllB) is allosterically activated by direct binding of the allantoin catabolic enzyme ...
Irina A. Rodionova +9 more
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Assessment of allantoin concentrations in comfrey root available on the Polish market
Acta Agrobotanica, 2023 Comfrey ( Symphytum officinale L.) root is a commonly known rich source of allantoin. This compound is widely used in pharmacy and cosmetology, but mainly in a synthetic form. However, the properties of natural allantoin in products of biological origin
Barbara Hawrylak-Nowak +1 more
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Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson’s disease
npj Parkinson's Disease, 2023 Oxidative stress supposedly plays a role in the pathogenesis of Parkinson’s disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative stress, was not ...
Lenka Hasíková +10 more
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Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
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Antioxidants, 2023 Allantoin is an emerging plant metabolite, but its role in conferring drought-induced oxidative stress is still elusive. Therefore, an experiment was devised to explore the role of allantoin (0.5 and 1.0 mM; foliar spray) in rapeseed (Brassica campestris
Md. Rakib Hossain Raihan +4 more
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Allantoin ameliorates chemically-induced pancreatic β-cell damage through activation of the imidazoline I3 receptors [PDF]
PeerJ, 2015 Objective. Allantoin is the primary active compound in yams (Dioscorea spp.). Recently, allantoin has been demonstrated to activate imidazoline 3 (I3) receptors located in pancreatic tissues.
Marie Amitani +8 more
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Dynamic Epistasis under Varying Environmental Perturbations [PDF]
, 2014 Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current knowledge for
Barker, Brandon, Gu, Zhenglong, Xu, Lin
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Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Non-alcoholic steatohepatitis (NASH) is defined by steatosis and inflammation in the hepatocytes, which can progress to cirrhosis and possibly hepatocellular carcinoma. However, current treatments are not entirely effective.
Tahereh Komeili Movahhed +3 more
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