Results 181 to 190 of about 595,057 (344)

Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma

, 2015
Imke Satzger, Lena Marks, Martin Kerick, Sven Klages, Carola Berking, Rudolf Herbst, B. Völker, Vivien Schacht, Bernd Timmermann, Ralf Gutzmer   +9 more
openalex   +2 more sources

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Uncovering heterogeneous intercommunity disease transmission from neutral allele frequency time series. [PDF]

Proc Natl Acad Sci U S A
Okada T, Isacchini G, Yu Q, Hallatschek O.   +3 more
europepmc   +1 more source

BCR/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors [PDF]

, 1996
Graham Pawelec, H. Max, Thomas Halder, Øyvind Bruserud, A Merl, P da Silva, Hubert Kalbacher   +6 more
openalex   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases [PDF]

, 2007
Kymberley Carter, Mark Worwood
openalex   +1 more source

The Impact of BRAF V600E Mutation Allele Frequency on the Histopathological Characteristics of Thyroid Cancer. [PDF]

Cancers (Basel), 2023
Abdulhaleem M, Bandargal S, Pusztaszeri MP, Rajab M, Greenspoon H, Krasner JR, Da Silva SD, Forest VI, Payne RJ.   +8 more
europepmc   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Low-Allele-Frequency Somatic Variants in a Cohort of Sporadic Saccular "Berry" Cerebral Aneurysms. [PDF]

J Am Heart Assoc
Karasozen Y, McAvoy M, Parada CA, Busald T, Kondaboina S, Osbun JW, Ruzevick J, Levitt MR, Gonzalez-Cuyar LF, Kim LJ, Dorschner MO, Ferreira M.   +11 more
europepmc   +1 more source

Homogeneity of pollen allele frequencies of single seed trees in Picea abies (L.) Karst. plantations [PDF]

, 1995
Reiner Finkeldey
openalex   +1 more source