Results 201 to 210 of about 595,057 (344)

KRAS Mutation Allele Frequency Dynamics in Plasma Extracellular Vesicles: Association with Survival in Localized Pancreatic Adenocarcinoma. [PDF]

Ann Surg Oncol
Chopra A, He HZ, Milosevic J, Tirukkovalur N, Asmar RE, Nassour I, Nunns G, Chen M, Chen J, Jiang S, Singhi AD, Saeed A, Zhang J, Lee K, Zureikat A, Zheng SY, Paniccia A.   +16 more
europepmc   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

High BRAF variant allele frequency predicts poor outcomes in metastatic melanoma patients treated with BRAF/MEK inhibitors. [PDF]

J Transl Med
Guida M, Apollonio B, Romano L, Spagnolo F, Quaglino P, Depenni R, Pinto R, Squicciarini T, Fucci L, Di Tullio P, Scaini MC, Maccallini MT, Indini A, Troiani T, Natalicchio I, Brugnara S, Lombardo M, Pellegrini C, Queirolo P, Perrone F, Minisini A, Tucci M, Conca R, Costabile S, Macrì M, Tanda E, Croce E, Senetta R, Fava P, Pugliese G, Pellegrini S, Melucci E, Vecchio MD, Caraglia F, Girlando S, De Summa S, Strippoli S, Italian Melanoma Intergroup (IMI).   +37 more
europepmc   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations. [PDF]

Sci Adv
Arbeithuber B, Anthony K, Higgins B, Oppelt P, Shebl O, Tiemann-Boege I, Chiaromonte F, Ebner T, Makova KD.   +8 more
europepmc   +1 more source

Allele frequency data for rice chromosome 12

Vahedi, Behrooz
openalex   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Von Willebrand factor and JAK2V617F variant allele frequency predict thrombosis and bleeding in patients with myeloproliferative neoplasms. [PDF]

Ann Hematol
Gat A, Kazoom R, Shapira I, Shai E, Roth Jelinek B, Buchman N, Kalish Y, Arad A, Zimran E.   +8 more
europepmc   +1 more source

Frequency of vernalization requirement associated dominant VRN-A1 gene and earliness related Esp-A1 candidate genes in advanced wheat mutant lines and effect of allele on flowering time

, 2016
Saule Kenzhebayeva, Gulina Doktyrbay, Nargul Omirbekova, Fatma Sarsu, Dauren Tashenev, A. Aibekova   +5 more
openalex   +1 more source

Allele and haplotype frequencies of 11 human leukocyte antigen loci in Koreans by next-generation sequencing

, 2022
Inseong Oh, Kiwook Jung, Jisoo G. Kim, Sue Shin, Eun Youn Roh, Yun Ji Hong, Eun Young Song   +6 more
openalex   +2 more sources