Results 221 to 230 of about 595,057 (344)

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Genome-Wide Allele Frequency Changes Reveal That Dynamic Metapopulations Evolve Differently. [PDF]

Mol Biol Evol
Angst P, Haag CR, Ben-Ami F, Fields PD, Ebert D.   +4 more
europepmc   +2 more sources

High <i>RAS</i> Allele Frequency Signals Increased Risk of <i>TERT</i> Promoter Mutations in Thyroid Tumors. [PDF]

Cancers (Basel)
Lefebvre C, Greenspoon H, Payne KE, Steinberg E, Tewfik F, Savoia G, da Silva SD, Pusztaszeri M, Forest VI, Payne RJ.   +9 more
europepmc   +1 more source

HLAfreq: Download and combine HLA allele frequency data

, 2023
Wells DA, McAuley M.
europepmc   +1 more source

αS1-casein alleles frequency in Carpathian goat.

, 2007
Valentin A. Bâlteanu, A. Vlaic, Felician Pop, Anda Raluca Rusu, Antonia Odagiu, V. Cighi, Șteofil Creangă   +6 more
openalex   +2 more sources

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

A path integral approach for allele frequency dynamics under polygenic selection. [PDF]

Genetics
Anderson NW, Kirk L, Schraiber JG, Ragsdale AP.   +3 more
europepmc   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Low Allele Frequency Variants Identified on Germline Multi-Gene Panel Testing for Cancer Predisposition Can Suggest the Presence of Constitutional Mosaicism. [PDF]

Clin Cancer Res
Rodriguez-Hernandez A, Polfus LM, Bychkovsky BL, Souders B, Prat A, Adamo B, Garber JE, Horton C, Rana HQ.   +8 more
europepmc   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source