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2011
Methods of estimating allele frequencies from data on unrelated and related individuals are described in this chapter. For samples of unrelated individuals with simple codominant markers, the natural estimator of allele frequencies can be used. For genetic data on related individuals, maximum likelihood estimation (MLE) can be applied to compute allele
Indra, Adrianto, Courtney, Montgomery
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Methods of estimating allele frequencies from data on unrelated and related individuals are described in this chapter. For samples of unrelated individuals with simple codominant markers, the natural estimator of allele frequencies can be used. For genetic data on related individuals, maximum likelihood estimation (MLE) can be applied to compute allele
Indra, Adrianto, Courtney, Montgomery
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Allele and Genotype Frequencies
2021Abstract An introduction to basic terminology in population genetics such as alleles, genotypes, and loci. This chapter introduces the basics of Hardy-Weinberg assumptions and predictions and explains how these assumptions can be used to provide insights and make basic inferences for real populations.
Áki J. Láruson, Floyd A. Reed
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2018
The allele frequency net database (AFND, http://www.allelefrequencies.net ) is an online web-based repository that contains information on the frequencies of immune-related genes and their corresponding alleles in worldwide human populations. At present, the system contains data from 1505 populations in more than ten million individuals on the ...
Faviel F, Gonzalez-Galarza +6 more
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The allele frequency net database (AFND, http://www.allelefrequencies.net ) is an online web-based repository that contains information on the frequencies of immune-related genes and their corresponding alleles in worldwide human populations. At present, the system contains data from 1505 populations in more than ten million individuals on the ...
Faviel F, Gonzalez-Galarza +6 more
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Alpha thalassemia allelic frequency in Lebanon
Pediatric Blood & Cancer, 2014BackgroundHemoglobinopathies are the most common reported monogenic disorders worldwide. It is well established that Mediterranean and Arab countries are high risk areas for thalassemia in general, and for alpha thalassemia in particular. Reports of alpha thalassemia gene mutations from the Lebanese population are limited.ProcedureWe investigated the ...
Chantal, Farra +8 more
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New allele frequency database: http://www.allelefrequencies.net
Tissue Antigens, 2003Abstract: A new website (http://www.allelefrequencies.net) has been compiled to execute the frequency of alleles at various polymorphic regions of different populations in the field of histocompatibility and immunogenetics. Data for HLA alleles has been added but this will be extended to include frequency data of polymorphisms in other immunogenetic ...
D, Middleton +3 more
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Approaches to allele frequency determination
Pharmacogenomics, 2000Hundreds of thousands of candidate single nucleotide polymorphisms (SNPs) are being identified as part of the human genome project. For these markers to be useful in any study their allele frequencies in the study population must be known, or much effort will be wasted when markers with the wrong characteristics are selected for studies involving large-
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Allele frequencies with genic selection
Journal of Mathematical Biology, 1983The structure of the limit point process of the ordered allele frequencies in the stationary distribution of a K-allele diffusion model with mutation and genic selection is studied. This leads to a formula for expectations of functions of the allele frequencies in terms of expectations in the neutral infinite alleles model.
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The allele frequency net database (AFND, http://www.allelefrequencies.net ) is an online web-based repository that contains information on the frequencies of immune-related genes and their corresponding alleles in worldwide human populations. At present, the website contains data from 1784 population samples in more than 14 million individuals from 129
Faviel F, Gonzalez-Galarza +5 more
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Faviel F, Gonzalez-Galarza +5 more
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Variability of allelic recombination frequencies
Molecular and General Genetics MGG, 1978Estimates of allelic recombination frequencies are shown to have coefficients of variation of between 20 and 40%. In Coprinus this is true of both high and low recombination frequencies and is also true when the alleles involved show marker effect. This variability is not confined to Coprinus but is a general feature of both meiotic and mitotic allelic
David Moore, Najah S. O. Katy
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