Results 1 to 10 of about 651 (138)

Wider recognition and greater understanding of postinfectious, antibiotic-refractory Lyme arthritis [PDF]

The Journal of Clinical Investigation
Lyme disease, caused by Borrelia burgdorferi (Bb), can progress to Lyme arthritis (LA). While most patients with LA respond successfully to antibiotic therapy, a small percentage fail to improve, a condition known as antibiotic-refractory Lyme arthritis (
Allen C. Steere, Jacob E. Lemieux
doaj   +3 more sources

Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination. [PDF]

PLoS Pathogens, 2023
Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but the microbial genetic elements underlying ...
Jacob E Lemieux, Weihua Huang, Nathan Hill, Tjasa Cerar, Lisa Freimark, Sergio Hernandez, Matteo Luban, Vera Maraspin, Petra Bogovič, Katarina Ogrinc, Eva Ruzič-Sabljič, Pascal Lapierre, Erica Lasek-Nesselquist, Navjot Singh, Radha Iyer, Dionysios Liveris, Kurt D Reed, John M Leong, John A Branda, Allen C Steere, Gary P Wormser, Franc Strle, Pardis C Sabeti, Ira Schwartz, Klemen Strle   +24 more
doaj   +4 more sources

Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis [PDF]

The Journal of Clinical Investigation, 2023
BACKGROUND Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis ...
Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila L. Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham, Alan G. Barbour, Catherine E. Costello, James J. Moon, Allen C. Steere   +13 more
doaj   +2 more sources

Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis [PDF]

Frontiers in Immunology
IntroductionClinical presentation of Lyme disease is largely due to host immune response to infection. Previously, we identified a variant (1805GG) in the TLR1 gene, a key immune sensor for Borrelia burgdorferi, which was associated with excessive ...
Morgan A. Williams, Sergio A. Hernandez, Sheila L. Arvikar, Katherine B. Sulka, Franc Strle, Christopher C. Wells, Tanja Petnicki-Ocwieja, Allen C. Steere, Klemen Strle   +8 more
doaj   +2 more sources

Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis [PDF]

iScience
Summary: Lyme arthritis, caused by the spirochete Borrelia burgdorferi, is the most common feature of late disseminated Lyme disease in the United States.
Kathryn A. Bowman, Christine D. Wiggins, Elizabeth DeRiso, Steffan Paul, Klemen Strle, John A. Branda, Allen C. Steere, Douglas A. Lauffenburger, Galit Alter   +8 more
doaj   +2 more sources

Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi. [PDF]

PLoS Pathogens
The spirochete Borrelia burgdorferi causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis even after antibiotic therapy.
Joshua W McCausland, Zachary A Kloos, Irnov Irnov, Nicole D Sonnert, Junhui Zhou, Rachel Putnik, Elizabeth A Mueller, Allen C Steere, Noah W Palm, Catherine L Grimes, Christine Jacobs-Wagner   +10 more
doaj   +2 more sources

Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States

Emerging Infectious Diseases, 2016
Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, and inflammatory potential.
Tjasa Cerar, Franc Strle, Dasa Stupica, Eva Ruzic-Sabljic, Gail McHugh, Allen C. Steere, Klemen Strle   +6 more
doaj   +1 more source

Care Needs for Patients Screened Positive for Cognitive Impairment and Delirium: A Cross‐Sectional Observational Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To describe the point prevalence of cognitive impairment in hospitalised adults and evaluate the association with care needs and perceived risks of complications. Design Multi‐site cross‐sectional study on a single day in May 2023. Methods Trained clinician auditors screened adult inpatients in acute medical, surgical, oncology, geriatric,
Alison M. Mudge, Sarah Anderson, Aparna Arjunan, Marguerite Byrnes, Margaret Cahill, Alison Craswell, Joel Dulhunty, Amanda Fox, Nicole C. Gavin, Peter Lawrenson, Karen Lee‐Steere, Hui‐Shan Lin, Andrew Teodorczuk, Elise Treleaven, Laura White, Chloe Yap   +15 more
wiley   +1 more source

Explosive Weapons Trauma Care Collective (EXTRACCT) Clinical Practice Guideline: Transfer of Critically Injured Casualties

World Journal of Surgery, Volume 50, Issue 8, Page 2455-2470, August 2026.
Blast‐injured patients often present to healthcare facilities which cannot definitively meet their clinical needs. This clinical practice guideline (CPG) reviews and describes best practice for inter‐facility transfer of casualties in resource limited and conflict‐afflicted contexts where there may not be a formal referral pathway or specialized inter ...
Emma Butterfield, Gavin Wooldridge, Solomon Abraha Asfaw, Mervat Alhilal, Mardi Steere, Benjamin W. Wachira, Paul Reavley, Roman Shtybel, Marius Rehn, On behalf of theEXTRACCT Clinical Practice Guidelines collaboration   +9 more
wiley   +1 more source

Procedural and Therapy Peripheral Intravenous Catheters: A Framework for Safety, Quality and Patient‐Centred Care

Journal of Advanced Nursing, Volume 82, Issue 8, Page 7748-7760, August 2026.
ABSTRACT Aim To introduce a novel conceptual framework that differentiates peripheral intravenous catheters according to their dwell time and therapeutic purpose, in order to improve the suitability of material choice, safety and cost‐effectiveness. Design Concept based on clinical guidelines, expert consensus and recent peer‐reviewed evidence.
Bertrand Drugeon, Claire M. Rickard, Nathan Peters, Vineet Chopra, Olivier Mimoz   +4 more
wiley   +1 more source