Results 11 to 20 of about 398 (93)

Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination. [PDF]

PLoS Pathogens, 2023
Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but the microbial genetic elements underlying ...
Jacob E Lemieux, Weihua Huang, Nathan Hill, Tjasa Cerar, Lisa Freimark, Sergio Hernandez, Matteo Luban, Vera Maraspin, Petra Bogovič, Katarina Ogrinc, Eva Ruzič-Sabljič, Pascal Lapierre, Erica Lasek-Nesselquist, Navjot Singh, Radha Iyer, Dionysios Liveris, Kurt D Reed, John M Leong, John A Branda, Allen C Steere, Gary P Wormser, Franc Strle, Pardis C Sabeti, Ira Schwartz, Klemen Strle   +24 more
doaj   +4 more sources

Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis [PDF]

The Journal of Clinical Investigation, 2023
BACKGROUND Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis ...
Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila L. Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham, Alan G. Barbour, Catherine E. Costello, James J. Moon, Allen C. Steere   +13 more
doaj   +2 more sources

Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis [PDF]

Frontiers in Immunology
IntroductionClinical presentation of Lyme disease is largely due to host immune response to infection. Previously, we identified a variant (1805GG) in the TLR1 gene, a key immune sensor for Borrelia burgdorferi, which was associated with excessive ...
Morgan A. Williams, Sergio A. Hernandez, Sheila L. Arvikar, Katherine B. Sulka, Franc Strle, Christopher C. Wells, Tanja Petnicki-Ocwieja, Allen C. Steere, Klemen Strle   +8 more
doaj   +2 more sources

Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis [PDF]

iScience
Summary: Lyme arthritis, caused by the spirochete Borrelia burgdorferi, is the most common feature of late disseminated Lyme disease in the United States.
Kathryn A. Bowman, Christine D. Wiggins, Elizabeth DeRiso, Steffan Paul, Klemen Strle, John A. Branda, Allen C. Steere, Douglas A. Lauffenburger, Galit Alter   +8 more
doaj   +2 more sources

Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi. [PDF]

PLoS Pathogens
The spirochete Borrelia burgdorferi causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis even after antibiotic therapy.
Joshua W McCausland, Zachary A Kloos, Irnov Irnov, Nicole D Sonnert, Junhui Zhou, Rachel Putnik, Elizabeth A Mueller, Allen C Steere, Noah W Palm, Catherine L Grimes, Christine Jacobs-Wagner   +10 more
doaj   +2 more sources

Wider recognition and greater understanding of postinfectious, antibiotic-refractory Lyme arthritis [PDF]

The Journal of Clinical Investigation
Lyme disease, caused by Borrelia burgdorferi (Bb), can progress to Lyme arthritis (LA). While most patients with LA respond successfully to antibiotic therapy, a small percentage fail to improve, a condition known as antibiotic-refractory Lyme arthritis (
Allen C. Steere, Jacob E. Lemieux
doaj   +2 more sources

Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States

Emerging Infectious Diseases, 2016
Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, and inflammatory potential.
Tjasa Cerar, Franc Strle, Dasa Stupica, Eva Ruzic-Sabljic, Gail McHugh, Allen C. Steere, Klemen Strle   +6 more
doaj   +1 more source

Care Needs for Patients Screened Positive for Cognitive Impairment and Delirium: A Cross‐Sectional Observational Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To describe the point prevalence of cognitive impairment in hospitalised adults and evaluate the association with care needs and perceived risks of complications. Design Multi‐site cross‐sectional study on a single day in May 2023. Methods Trained clinician auditors screened adult inpatients in acute medical, surgical, oncology, geriatric,
Alison M. Mudge, Sarah Anderson, Aparna Arjunan, Marguerite Byrnes, Margaret Cahill, Alison Craswell, Joel Dulhunty, Amanda Fox, Nicole C. Gavin, Peter Lawrenson, Karen Lee‐Steere, Hui‐Shan Lin, Andrew Teodorczuk, Elise Treleaven, Laura White, Chloe Yap   +15 more
wiley   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Life after herbarium digitisation: Physical and digital collections, curation and use

PLANTS, PEOPLE, PLANET, Volume 8, Issue 4, Page 1029-1041, July 2026.
Societal Impact Statement Collections of dried plant specimens (herbaria) provide an invaluable resource for the study of many areas of scientific interest and conservation globally. Digitisation increases access to specimens and metadata, enabling efficient use across a broad spectrum of research.
Alan James Paton, Gabriel K. Ameka, Alexandre Antonelli, Alex Asase, Russell L. Barrett, Ann Bogaerts, Domingos Cardoso, Mark Carine, Alastair Culham, Syadwina H. Dalimunthe, Nina Davies, Sofie De Smedt, Sebebe Demissew, Rafaela Campostrini Forzza, Quentin Groom, Elspeth M. Haston, Abdulrokhman Kartonegoro, Paul Kersey, Isabel Larridon, Jana Leong‐Škorničková, Lucia G. Lohmann, Jehova Lourenco Jr., Hannah McPherson, Muthama Muasya, Nicky Nicolson, Marcelo Pace, Jack F. Plummer, Hélène Ralimanana, Himmah Rustiami, Hervé Sauquet, Emily B. Sessa, Eric Smets, Alex Sumadijaya, Jordan Teisher, Daniel C. Thomas, Eka F. Tihurua, Janine E. Victor, Sarah T. Wagner, Quiang Wang, Andrew Young   +39 more
wiley   +1 more source