Results 1 to 10 of about 146,627 (304)

Allergen-Specific Antibodies Regulate Secondary Allergen-Specific Immune Responses

Frontiers in Immunology, 2019
Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensensitivity disease. It is based on the production of IgE antibodies and T cell responses against per se innocuous antigens (i.e., allergens) and subsequent ...
Rudolf Valenta, Julia Eckl-Dorna, Birgit Linhart   +2 more
exaly   +4 more sources

Allergen Extracts for In Vivo Diagnosis and Treatment of Allergy: Is There a Future?

Journal of Allergy and Clinical Immunology: in Practice, 2018
Today, in vivo allergy diagnosis and allergen-specific immunotherapy (AIT) are still based on allergen extracts obtained from natural allergen sources.
Rudolf Valenta, Musa Khaitov, Yury Zhernov   +2 more
exaly   +2 more sources

Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future

Journal of Allergy and Clinical Immunology, 2016
In the past, the development of more effective, safe, convenient, broadly applicable, and easy to manufacture vaccines for allergen-specific immunotherapy (AIT) has been limited by the poor quality of natural allergen extracts. Progress made in the field
Rudolf Valenta, Raffaela Campana, Margarete Focke   +2 more
exaly   +2 more sources

Allergen immunotherapy: past, present and future

Nature reviews. Immunology, 2022
Durham and Shamji review the history and future of allergen immunotherapy for established IgE-mediated hypersensitivity to common allergens. They describe the mechanisms of immunotherapy-induced tolerance and the new strategies being explored to achieve ...
S. Durham, M. Shamji
semanticscholar   +1 more source

The role of allergen‐specific IgE, IgG and IgA in allergic disease

Allergy. European Journal of Allergy and Clinical Immunology, 2021
Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease affecting more than 30% of the population. Exposure to even minute quantities of allergens can lead to the production of IgE antibodies in atopic individuals.
M. Shamji, R. Valenta, T. Jardetzky, V. Verhasselt, S. Durham, P. Würtzen, R. van Neerven   +6 more
semanticscholar   +1 more source

Novel BC02 Compound Adjuvant Enhances Adaptive and Innate Immunity Induced by Recombinant Glycoprotein E of Varicella-Zoster Virus

Vaccines, 2022
Both adaptive and innate immunity responses are necessary for the efficient elimination of different pathogens. However, the magnitude, quality and desired type of immune response specific to the co-administered antigen is largely determined by adjuvants.
Junli Li, Lili Fu, Xiaonan Guo, Yang Yang, Jiaxin Dong, Guozhi Wang, Aihua Zhao   +6 more
doaj   +1 more source

Enhanced Potency and Persistence of Immunity to Varicella-Zoster Virus Glycoprotein E in Mice by Addition of a Novel BC02 Compound Adjuvant

Vaccines, 2022
Herpes zoster (HZ) is one of two distinct syndromes caused by Varicella-zoster virus (VZV). A primary infection with VZV causes varicella in susceptible young children.
Junli Li, Lili Fu, Yang Yang, Guozhi Wang, Aihua Zhao   +4 more
doaj   +1 more source

Past, Present and Future of Bacillus Calmette-Guérin Vaccine Use in China

Vaccines, 2022
The BCG vaccine is prepared from a weakened strain of Mycobacterium bovis (M. bovis), a bacterium closely related to Mycobacterium tuberculosis (MTB), which causes tuberculosis (TB).
Junli Li, Jinbiao Lu, Guozhi Wang, Aihua Zhao, Miao Xu   +4 more
doaj   +1 more source

Comparison of the Immune Responses to Different Formulations of BC02-Adjuvanted HPV Types 16 and 18 Bivalent Vaccines in Mice

Vaccines, 2023
To achieve maximum efficacy, vaccines, such as subunit, recombinant, and conjugate vaccines, necessitate the incorporation of immunostimulators/adjuvants.
Junli Li, Huicong Xie, Lili Fu, Xiaonan Guo, Jiaxin Dong, Miao Xu, Guozhi Wang, Aihua Zhao   +7 more
doaj   +1 more source

Non‐specific lipid‐transfer proteins: Allergen structure and function, cross‐reactivity, sensitization, and epidemiology

Clinical and Translational Allergy, 2021
Background Discovered and described 40 years ago, non‐specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought.
I. Skypala, R. Asero, D. Barber, L. Cecchi, Arazeli Diaz Perales, K. Hoffmann-Sommergruber, E. Pastorello, I. Swoboda, J. Bartra, D. Ebo, M. Faber, M. Fernández-Rivas, F. Gomez, A. Konstantinopoulos, O. Luengo, Ronald van Ree, E. Scala, S. Till   +17 more
semanticscholar   +1 more source