Results 21 to 30 of about 135,884 (265)

Preventing Atopic Diseases During Childhood – Early Exposure Matters

Frontiers in Immunology, 2021
Atopic diseases in childhood are a major burden worldwide and there is still a lack of knowledge about treatable causes. In industrialized countries such as Germany, almost every second child is sensitized to at least one common allergen.
Mandy Pierau, Aditya Arra, Monika C. Brunner-Weinzierl   +2 more
doaj   +1 more source

Spectrum of Allergens and Allergen Biology in India [PDF]

International Archives of Allergy and Immunology, 2018
The growing prevalence of allergy and asthma in India has become a major health concern with symptoms ranging from mild rhinitis to severe asthma and even life-threatening anaphylaxis. The “allergen repertoire” of this subcontinent is highly diverse due to the varied climate, flora, and food habits.
Kashinath, Bhattacharya, Gaurab, Sircar, Angira, Dasgupta, Swati, Gupta Bhattacharya   +3 more
openaire   +2 more sources

Allergen-Specific Immunotherapy With Liposome Containing CpG-ODN in Murine Model of Asthma Relies on MyD88 Signaling in Dendritic Cells

Frontiers in Immunology, 2020
Changing the immune responses to allergens is the cornerstone of allergen immunotherapy. Allergen-specific immunotherapy that consists of repeated administration of increasing doses of allergen extract is potentially curative. The major inconveniences of
Ricardo Wesley Alberca-Custodio, Lucas D. Faustino, Eliane Gomes, Fernanda Peixoto Barbosa Nunes, Mirian Krystel de Siqueira, Alexis Labrada, Rafael Ribeiro Almeida, Niels Olsen Saraiva Câmara, Denise Morais da Fonseca, Momtchilo Russo   +9 more
doaj   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Eosinophilic Pneumonia Triggered by Toxocara canis in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report

Medicina
Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects the structure and function of cilia, primarily impacting the respiratory system.
Kacper Packi, Wanda Fugiel, Violetta Gołąbek, Alicja Rudek, Agnieszka Śliwińska   +4 more
doaj   +1 more source

Early inhalant allergen sensitization at component level: an analysis in atopic Dutch children

Frontiers in Allergy, 2023
BackgroundAllergic rhinitis is a common respiratory disease in children and sensitization to inhalant allergens plays a significant role in its development.
Lonneke J. Landzaat, Joyce A. M. Emons, Laura J. H. Sonneveld, Marco W. J. Schreurs, Nicolette J. T. Arends   +4 more
doaj   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, EarlyView.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source

Testing and Simulation of Multilayer Polyvinylidene Fluoride‐Based Piezoelectric Energy Harvester Devices

Advanced Materials Technologies, EarlyView.
The study considers the use of polymer/dielectric‐based multilayers piezoelectric Energy Harvesters (EH) to produce an output voltage and current, by exploiting the mechanical energy provided by human organs movements. In particular, the heart motion is considered from the kinematic viewpoint, and a multiphysics theoretical model is developed to assess
Hamdi Ezzin, Silvia Monchetti, Paolo Emilio Puddu, Luciano Teresi, Antonio DeSimone, Roberto Brighenti   +5 more
wiley   +1 more source

Molecular Engineering Mediated Interfacial Assembly as an Artificial Extracellular Matrix Remolds Bacteria With Enhanced Abiotic Resilience

Advanced Science, EarlyView.
A biomimetic artificial extracellular matrix is assembled directly on Pseudomonas fluorescens by co‐assembling amyloid‐like lysozyme and alginate at the cell surface. This conformal nanocoating acts as both a hydration buffer and a physiological priming layer, markedly enhancing desiccation tolerance, seed adhesion, storage stability, and biocontrol ...
Yuanyuan Wang, Zili Jia, Yang Li, Qitao Wang, Shuai Hou, Lei Liu   +5 more
wiley   +1 more source

BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models

Human Vaccines & Immunotherapeutics
After infection with the varicella-zoster virus (VZV), the virus becomes latent in the sensory ganglia. Immune senescence may lead to its reactivation, resulting in herpes zoster (HZ). The limited immunogenicity of current vaccines in elderly populations
Junli Li, Xiaochi Li, Yang Yang, LiLi Fu, Weixin Du, Jiazheng Wei, Kexin Su, Cheng Su, Xiaobing Shen, Guozhi Wang, Aihua Zhao   +10 more
doaj   +1 more source