Climate change, aeroallergens, and the aeroexposome
Environmental Research Letters, 2021 Allergic diseases are a major public health problem globally and are increasing. The impacts of climate change on aeroallergens such as pollen and fungal spores and allergic respiratory diseases such as allergic asthma and allergic rhinitis have been ...
Paul J Beggs
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Frontiers in Genetics, 2021 Environmental exposures have been linked to increased asthma risk, particularly during pregnancy and in early life. Here we use a mouse model of allergic lung disease to examine the effects of pre- and perinatal house dust mite (HDM) allergen exposure on
Jairus C. Pulczinski +8 more
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Genomic and transcriptional analysis of allergen genes in apple (Malus x domestica) [PDF]
, 2010 Apple consumption is highly recomended for a healthy diet and is the most important fruit produced in temperate climate regions. Unfortunately, it is also one of the fruit that most ofthen provoks allergy in atopic patients and the only treatment ...
Pagliarani, Giulia <1981>
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Regulation and directed inhibition of ECP production by human neutrophils
Frontiers in Immunology, 2022 BackgroundNeutrophils are involved in the pathophysiology of allergic asthma, where the Eosinophil Cationic Protein (ECP) is a critical inflammatory mediator.
Antonio Vega-Rioja +18 more
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Allergen sensitization associates with worse lung function parameters [PDF]
, 2022 To assess the association between the number of allergen sensitizations and lung function variables in individuals with airway symptoms. Methods. Retrospective study with all individuals who performed lung function and skin-prick tests at CUF-Porto (01 ...
Gonçalves, I. +4 more
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What Makes an Allergen an Allergen [PDF]
Allergy, 1978 In the vocabulary of daily life the term allergen is most often used to indicate the whole substance able to initiate an allergic reaction, such as certain pollens, moulds, house dust mites, animal dander, cow's milk and other inhalants or food items known to trigger immediate or late, hypersensitivity reactions.
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Allergen Peptides, Recombinant Allergens and Hypoallergens for Allergen-Specific Immunotherapy [PDF]
Current Treatment Options in Allergy, 2014 Allergic diseases are among the most common health issues worldwide. Specific immunotherapy has remained the only disease-modifying treatment, but it is not effective in all patients and may cause side effects. Over the last 25 years, allergen molecules from most prevalent allergen sources have been isolated and produced as recombinant proteins.
Marth, Katharina +4 more
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Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites [PDF]
, 2011 Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic
Ball, G. +33 more
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Preventing Atopic Diseases During Childhood – Early Exposure Matters
Frontiers in Immunology, 2021 Atopic diseases in childhood are a major burden worldwide and there is still a lack of knowledge about treatable causes. In industrialized countries such as Germany, almost every second child is sensitized to at least one common allergen.
Mandy Pierau +2 more
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The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. [PDF]
, 2014 Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Newton, GK +14 more
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