Results 71 to 80 of about 177,465 (363)

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

Exploring plant polyphenols as anti-allergic functional products to manage the growing incidence of food allergy

Frontiers in Nutrition, 2023
The active substances derived from plants have received increasing attention owing to their wide range of pharmacological applications, including anti-tumor, anti-allergic, anti-viral, and anti-oxidative activities.
Tianxiang Wu, Tianxiang Wu, Tianxiang Wu, Zhenxing Li, Zhenxing Li, Yanyan Wu, Yanyan Wu, Yanyan Wu, Xianqing Yang, Xianqing Yang, Xianqing Yang, Laihao Li, Laihao Li, Laihao Li, Shengjun Chen, Shengjun Chen, Bo Qi, Bo Qi, Yueqi Wang, Yueqi Wang, Chunsheng Li, Chunsheng Li, Yongqiang Zhao, Yongqiang Zhao, Yongqiang Zhao   +24 more
doaj   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Food-specific sublingual immunotherapy is well tolerated and safe in healthy dogs : a blind, randomized, placebo-controlled study [PDF]

, 2017
Background: Food allergies are increasing in prevalence but no treatment strategies are currently available to cure dogs with food allergy. Over the past decade, experimental food allergen-specific sublingual immunotherapy (FA-SLIT) has emerged as a ...
Cox, Eric, Hesta, Myriam, Maina, Elisa, Pelst, Michael   +3 more
core   +2 more sources

Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL) Sensitization to inhalant and food allergens in Brazilian atopic children by in vitro total and specific IgE assay: Allergy Project - PROAL

Jornal de Pediatria, 2004
OBJETIVO: Determinar a freqüência de sensibilização a alérgenos inalantes e alimentares em crianças atendidas em serviços brasileiros de alergia. PACIENTES E MÉTODOS: IgE sérica total e específica (RAST) a alérgenos inalantes e alimentares (UniCAP ...
Charles K. Naspitz, Dirceu Solé, Cristina A. Jacob, Emanuel Sarinho, Francisco J. P. Soares, Vera Dantas, Márcia C. Mallozi, Neusa F. Wandalsen, Wellington Borges, Wilson Rocha Filho, Grupo PROAL   +10 more
doaj   +1 more source

Differential Immune Cell Infiltration in Eosinophilic and Non‐Eosinophilic CRS: Correlations With Clinical, Endoscopic, and Radiological Findings

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non‐eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
Katarzyna Czerwaty, Katarzyna Piszczatowska, Mirosław J. Szczepański, Natalia Jermakow, Nils Ludwig, Karolina Dżaman   +5 more
wiley   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

Intra-cervical lymphatic immunotherapy for dust mite-induced allergic rhinoconjunctivitis in children: a 3-year prospective randomized controlled trial

Frontiers in Immunology, 2023
BackgroundPediatric allergic rhinoconjunctivitis has become a public concern with an increasing incidence year by year. Conventional subcutaneous immunotherapy (SCIT) has long treatment time, high cost and poor compliance.
Qixing Wang, Kai Wang, Yang Qin, Weijun Huang, Yin Li, Qingqing Yu, Yu Xiong, Yingwei Guo, Rui Zheng, Rui Zheng, Jun Tang, Jun Tang   +11 more
doaj   +1 more source

Chitinases as Food Allergens

Molecules, 2019
Food allergies originate from adverse immune reactions to some food components. Ingestion of food allergens can cause effects of varying severity, from mild itching to severe anaphylaxis reactions.
Claudia Leoni, Mariateresa Volpicella, Maria C.G. Dileo, Bruno A.R. Gattulli, Luigi R. Ceci   +4 more
doaj   +1 more source

Microarray Technology May Reveal the Contribution of Allergen Exposure and Rhinovirus Infections as Possible Triggers for Acute Wheezing Attacks in Preschool Children

Viruses, 2021
Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. The identification of such trigger factors is difficult but may have therapeutic implications. Increases of IgE and IgG in sera, were
Katarzyna Niespodziana, Katarina Stenberg-Hammar, Nikolaos G. Papadopoulos, Margarete Focke-Tejkl, Peter Errhalt, Jon R. Konradsen, Cilla Söderhäll, Marianne van Hage, Gunilla Hedlin, Rudolf Valenta   +9 more
doaj   +1 more source