Results 41 to 50 of about 92,614 (315)

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.

, 2014
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Newton, GK, Jenkins, K, Robinson, C, Garrod, DR, Richardson, JP, Key, RE, Perrior, TR, Major, MR, Firth-Clark, S, Chen, J, Francis-Newton, NJ, Lloyd, SM, Stewart, MR, Zhang, J, Lai, P   +14 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

The Safety of Ethnic Foods in Campania Region: A Preliminary Study

Foods, 2023
Ethnic food is produced by an ethnic group—using their familiarity with local ingredients of plants and/or animal origin—and it is consumed in a country other than the country of origin.
Loredana Biondi, Andrea Fulgione, Assunta De Lella, Anna Cutarelli, Morena Nappa, Francesca Garofalo, Stefania Cavallo, Donatella Nava   +7 more
doaj   +1 more source

Testing and Simulation of Multilayer Polyvinylidene Fluoride‐Based Piezoelectric Energy Harvester Devices

Advanced Materials Technologies, EarlyView.
The study considers the use of polymer/dielectric‐based multilayers piezoelectric Energy Harvesters (EH) to produce an output voltage and current, by exploiting the mechanical energy provided by human organs movements. In particular, the heart motion is considered from the kinematic viewpoint, and a multiphysics theoretical model is developed to assess
Hamdi Ezzin, Silvia Monchetti, Paolo Emilio Puddu, Luciano Teresi, Antonio DeSimone, Roberto Brighenti   +5 more
wiley   +1 more source

Erroneous Belief that Digestive Stability Predicts Allergenicity May Lead to Greater Risk for Novel Food Proteins

Frontiers in Bioengineering and Biotechnology, 2021
There continues to be an erroneous belief that allergens (especially food allergens) are more resistant to gastrointestinal digestion than non-allergens.
Rod A. Herman, Jason M. Roper
doaj   +1 more source

Molecular Engineering Mediated Interfacial Assembly as an Artificial Extracellular Matrix Remolds Bacteria With Enhanced Abiotic Resilience

Advanced Science, EarlyView.
A biomimetic artificial extracellular matrix is assembled directly on Pseudomonas fluorescens by co‐assembling amyloid‐like lysozyme and alginate at the cell surface. This conformal nanocoating acts as both a hydration buffer and a physiological priming layer, markedly enhancing desiccation tolerance, seed adhesion, storage stability, and biocontrol ...
Yuanyuan Wang, Zili Jia, Yang Li, Qitao Wang, Shuai Hou, Lei Liu   +5 more
wiley   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Nanoparticle–allergen complexes for allergen immunotherapy

International Journal of Nanomedicine, 2017
Allergen-specific immunotherapy was introduced in clinical settings more than 100 years ago. It remains the only curative approach to treating allergic disorders that ameliorates symptoms, reduces medication costs, and blocks the onset of new sensitizations.
Paolo Colombo, Gabriella Di Felice
openaire   +5 more sources

Fish Allergens at a Glance: Variable Allergenicity of Parvalbumins, the Major Fish Allergens [PDF]

Frontiers in Immunology, 2014
Fish is a common trigger of severe, food-allergic reactions. Only a limited number of proteins induce specific IgE-mediated immune reactions. The major fish allergens are the parvalbumins. They are members of the calcium-binding EF-hand protein family characterized by a conserved protein structure.
Annette eKuehn, Ines eSwoboda, Karthik eArumugam, Christiane eHilger, François eHentges, François eHentges   +5 more
openaire   +3 more sources

T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects

, 2009
Lipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied.
Tordesillas Villuendas, Leticia, Sánchez-Monge Laguna de Rins, Rosa, Gonzalez-Muñoz, Miguel, Salcedo Duran, Gabriel, Pacios, Luis F., Compes, Esther, Díaz Perales, Araceli, Belen Garcia-Carrasco, Esther Compés, Cuesta-Herranz, Javier, Gabriel Salcedo, Rosa Sanchez-Monge, Miguel Gonzalez-Muñoz, Javier Cuesta-Herranz, Leticia Tordesillas, Garcia-Carrasco, Belen, Luis F. Pacios, Araceli Diaz-Perales   +17 more
core   +1 more source