Results 11 to 20 of about 5,950 (136)

Quantitative and qualitative analysis of the antifungal activity of allicin alone and in combination with antifungal drugs. [PDF]

PLoS ONE, 2012
The antifungal activity of allicin and its synergistic effects with the antifungal agents flucytosine and amphotericin B (AmB) were investigated in Candida albicans (C. albicans). C.
Young-Sun Kim, Kyung Sook Kim, Ihn Han, Mi-Hyun Kim, Min Hyung Jung, Hun-Kuk Park   +5 more
doaj   +1 more source

Allicin shows antifungal efficacy against Cryptococcus neoformans by blocking the fungal cell membrane

Frontiers in Microbiology, 2022
Allicin, which is generated by the catalytic reaction between alliin and alliinase extracted from garlic, has been shown to have a wide range of antimicrobial activities, but its anti-Cryptococcus efficacy and mechanism are not quite clear. Here, we have
Zhun Li, Zhengtu Li, Jun Yang, Chun Lu, Yongming Li, Yinzhu Luo, Feng Cong, Rongmei Shi, Zhen Wang, Huaying Chen, Xinxia Li, Jinglu Yang, Feng Ye   +12 more
doaj   +1 more source

Allicin Facilitates Airway Surface Liquid Hydration by Activation of CFTR

Frontiers in Pharmacology, 2022
Airway epithelium plays critical roles in regulating airway surface liquid (ASL), the alteration of which causes mucus stasis symptoms. Allicin is a compound released from garlic and harbors the capacity of lung-protection.
Zhuo-Er Qiu, Jian-Bang Xu, Jian-Bang Xu, Lei Chen, Ze-Xin Huang, Tian-Lun Lei, Zi-Yang Huang, Xiao-Chun Hou, Hai-Long Yang, Qin-Hua Lin, Yun-Xin Zhu, Lei Zhao, Lei Zhao, Wen-Liang Zhou, Yi-Lin Zhang   +14 more
doaj   +1 more source

Allicin Modulates the Antioxidation and Detoxification Capabilities of Primary Rat Hepatocytes

Journal of Traditional and Complementary Medicine, 2012
The effect of allicin, an active ingredient of garlic, on lactate dehydrogenase (LDH) leakage, lipid peroxidation, glutathione (GSH) content, and GSH-related enzyme activity was investigated in primary hepatocytes.
Chih-Chung Wu, Yung-Lin Chu, Lee-Yan Sheen   +2 more
doaj   +1 more source

Allicin-induced Activation of Peristalsis in Rat Ileum Depends on Bicarbonate Ion Transport [PDF]

Iranian Journal of Colorectal Research, 2023
Background: Allicin, a main component of garlic, possesses various beneficial pharmacological and therapeutic properties, including anticarcinogenic, bactericidal, and intestinal regulatory effects. Although it is known to regulate intestinal contraction
Yo Tsuchiya, Nozomi Sasaki, Sae Satou, Kana Tozawa   +3 more
doaj   +1 more source

Allicin Alleviates Inflammation of Trinitrobenzenesulfonic Acid-Induced Rats and Suppresses P38 and JNK Pathways in Caco-2 Cells

Mediators of Inflammation, 2015
Background. Allicin has anti-inflammatory, antioxidative and proapoptotic properties. Aims. To evaluate the effects and investigate the mechanism of allicin on trinitrobenzenesulfonic acid-induced colitis, specifically with mesalazine or sulfasalazine ...
Chen Li, Weijian Lun, Xinmei Zhao, Shan Lei, Yandong Guo, Jiayi Ma, Fachao Zhi   +6 more
doaj   +1 more source

Allicin: Chemistry and Biological Properties

Molecules, 2014
Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with a broad range of biological activities. Allicin is produced upon tissue damage from the non-proteinogenic amino acid alliin (S-allylcysteine sulfoxide) in a ...
Jan Borlinghaus, Frank Albrecht, Martin C. H. Gruhlke, Ifeanyi D. Nwachukwu, Alan J. Slusarenko   +4 more
doaj   +1 more source

Introducing of some species of genus Allium subgenus Melanocrommyum from Iran as new sources of allicin

Acta Agriculturae Slovenica, 2020
Allicin is a sulfur compound found in genus Allium characterized by numerous biological and pharmacological properties. Melanocrommyum, the second largest subgenus of Allium, has about 10 sections and 82 species in Iran. In this study, allicin content of
Mahboobeh ZARE MEHRJERDI, Mahdi MORIDI FARIMANI, Mahdi ABBAS MOHAMMADI, Jalal REZAEI   +3 more
doaj   +1 more source

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

iScience, 2020
Summary: Brown adipose tissue (BAT) is a promising potential therapeutic target for the treatment of obesity and related metabolic diseases. Allicin, a natural product in garlic, has multiple biological and pharmacological functions. However, the role of
Chuanhai Zhang, Xiaoyun He, Yao Sheng, Jia Xu, Cui Yang, Shujuan Zheng, Junyu Liu, Haoyu Li, Jianbing Ge, Minglan Yang, Baiqiang Zhai, Wentao Xu, Yunbo Luo, Kunlun Huang   +13 more
doaj   +1 more source

Cellular uptake of allicin in the hCMEC/D3 human brain endothelial cells: exploring blood-brain barrier penetration in an in vitro model [PDF]

PeerJ
Background Allicin, a bioactive compound derived from garlic (Allium sativum), demonstrates antibacterial activity against a broad spectrum of bacteria including the most common meningitis pathogens.
Kankawi Satsantitham, Pishyaporn Sritangos, Sirawit Wet-osot, Nuannoi Chudapongse, Oratai Weeranantanapan   +4 more
doaj   +2 more sources