Results 1 to 10 of about 4,990 (168)

De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019

Journal of Infection and Public Health, 2022
The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies.
Jean Feuillard, Xavier Lafarge, Bruno François   +2 more
exaly   +4 more sources

Evaluation of Immune Functions in Transfusion-Dependent Thalassemia Patients with Alloimmunization [PDF]

Turkish Journal of Hematology
Objective: Regular erythrocyte suspension transfusions are still performed for most patients with beta-thalassemia major to prevent anemia. In recent years, it has been observed that patients are exposed to multiple allogeneic antigens and this leads to ...
Nazli Özge Özköteş, Tuba Hilkay Karapınar, Sultan Okur Acar, Yüce Ayhan, Nesrin Gülez, Yeşim Oymak, Ferah Genel   +6 more
doaj   +2 more sources

Antibody-Dependent and Antibody-Independent Hemolysis in Sickle Cell Disease [PDF]

Antibodies
Sickle cell disease (SCD) represents one of the most complex hematological diseases leading to a lifetime of physiological crises characterized by chronic hemolysis, inflammation, hypoxia, and anemia with changes to body systems that result in patients ...
Raeshun T. Glover, Robert W. Maitta
doaj   +2 more sources

Global Prevalence and Specificity of Red Blood Cell Antibodies in Blood Donors: A Systematic Review and Meta-Analysis [PDF]

Diseases
Background: Red blood cell (RBC) antibody screening in blood donors is a key component of transfusion safety. However, reported prevalence and antibody specificities vary widely across studies, and a consolidated global estimate remains limited.
Thitinat Duangchan, Moltira Promkan, Susan D. Kraner, Nurdina Charong   +3 more
doaj   +2 more sources

Prevalence of Alloantibodies in Thalassemia Patients and Its Relationship With Age, Gender and Blood Group

Acta Medica Iranica, 2023
To determine the prevalence of alloantibodies in patients with thalassemia and its relationship with age, sex, and blood group. A cross-sectional study was conducted on thalassemia patients requiring a blood transfusion presenting to Children’s Medical ...
Leili Koochakzadeh, Mohammad Kajiyazdi, Fahimeh Khoshhal, Alireza Hashemi, Mehdi Khabazkhoob   +4 more
doaj   +1 more source

Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization

Frontiers in Immunology, 2021
There is an urgent need for therapeutic interventions for desensitization and antibody-mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific HLA antibodies (DSA).
Ashley Y. Choi, Miriam Manook, Danae Olaso, Brian Ezekian, Jaeberm Park, Kyle Freischlag, Annette Jackson, Stuart Knechtle, Jean Kwun   +8 more
doaj   +1 more source

Characteristics of tumor patients with anti-P1 antibody: a retrospective study

Zhongguo shuxue zazhi, 2023
Objective To evaluate the detection and distribution characteristics of anti-P1 in tumor patients, so as to aid in blood screening and transfusion safety. Methods The clinical data of 112 658 tumor patients who underwent blood preparation and transfusion
Simeng CHEN, Jingjing YU, Juan CAI, Min LIU, Tao PENG, Weiwei FANG, Ruijuan ZHAO, Xiying LI   +7 more
doaj   +1 more source

Cellular and Humoral Immunogenicity Investigation of Single and Repeated Allogeneic Tenogenic Primed Mesenchymal Stem Cell Treatments in Horses Suffering From Tendon Injuries

Frontiers in Veterinary Science, 2022
The use of mesenchymal stem cells (MSCs) for the treatment of equine tendon disease is widely investigated because of their regenerative and immunomodulatory potential.
Eva Depuydt, Eva Depuydt, Sarah Y. Broeckx, Koen Chiers, Marco Patruno, Laura Da Dalt, Luc Duchateau, Jimmy Saunders, Frederik Pille, Ann Martens, Lore Van Hecke, Jan H. Spaas, Jan H. Spaas   +12 more
doaj   +1 more source

Central hepatectomy for hepatocellular carcinoma in a patient with anti-Gerbich antibody

Surgical Case Reports, 2020
Background Anti-Gerbich (Ge) alloantibody against high-frequency erythrocyte antigen is extremely rare. Owing to incomplete evidence regarding the degree and severity of adverse events induced by hemolytic transfusion reactions, the transfusion ...
Teruo Komokata, Maki Inoue, Bibek Aryal, Hiroto Yasumura, Chinami Mori, Mituharu Nomoto, Mamoru Kaieda, Shuichi Hanada   +7 more
doaj   +1 more source

Defining the structural basis for human leukocyte antigen reactivity in clinical transplantation

Scientific Reports, 2020
The current state-of-the-art technology employed to assess anti-human leukocyte antigen antibodies (Anti-HLA Ab) for donor-recipient matching and patient risk stratification in renal transplantation is the single antigen bead (SAB) assay.
Yue Gu, Robynne W. K. Koh, May Ling Lai, Denise Pochinco, Rachel Z. C. Teo, Marieta Chan, Tanusya M. Murali, Chong Wai Liew, Yee Hwa Wong, Nicholas R. J. Gascoigne, Kathryn J. Wood, Julien Lescar, Peter Nickerson, Paul A. MacAry, Anantharaman Vathsala   +14 more
doaj   +1 more source