Results 31 to 40 of about 4,990 (168)

Reproducibility of phagocytosis rates of alloantibody specificity anti-c by monocyte monolayer assay (MMA)

, 2022
Im Zuge der Transfusion von Erythrozytenkonzentraten gilt es Komplikationen, wie zum Beispiel hämolytische Transfusionsreaktionen, zu vermeiden. Diese können unter anderem durch Alloantikörper verursacht werden, die gegen Antigene gerichtet sind, welche ...
Ott, Theresa
core   +2 more sources

Alloimmunization in autoimmune hemolytic anemia patient: The differential adsorption approach

Asian Journal of Transfusion Science, 2017
Patients of β-thalassemia major are dependent on regular blood transfusions for their entire lifetime. Development of antibodies against red blood cell (RBC) antigen which may be alloantibody or autoantibody, several times as a result of frequent red ...
Ravi C Dara, Aseem Kumar Tiwari, Dinesh Arora, Subhasis Mitra, Devi Prasad Acharya, Geet Aggarwal, Jyoti Sharma   +6 more
doaj   +1 more source

Prevalence of irregular red cell antibody in healthy blood donors attending a tertiary care hospital in North India

Asian Journal of Transfusion Science, 2018
Background: Alloantibodies may be detected in blood donors who have either been transfused previously or female donors with previous obstetric events.
Raj Nath Makroo, Saroj Rajput, Soma Agarwal, Mohit Chowdhry, Bindu Prakash, Prashant Karna   +5 more
doaj   +1 more source

Cell Surface Expression of CD154 Inhibits Alloantibody Responses: A Mechanism for the Prevention of Autoimmune Responses against Activated T Cells?

, 1999
Binding of CD40 by CD154 expressed on activated T cells is a pivotal event in T cell help to B cells, macrophages, and other antigen-presenting cells.
Heath, A.W., Santos-Argumedo, L., Thomas, M.S., McCormick, A.L.   +3 more
core   +1 more source

IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154–CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice

Frontiers in Immunology, 2017
In recent years, regulatory T cells (Treg)-based immunotherapy has emerged as a promising strategy to promote operational tolerance after solid organ transplantation (SOT).
Dela Golshayan, Lerisa Govender, Jean-Christophe Wyss, Rajesh Kumar, Manuel Pascual   +4 more
doaj   +1 more source

Anti‐Erythrocyte Antibody Formation in Individuals With and Without Known Sensitisation Pathways Reflecting Indications for Extended Immunohaematology Screening

Journal of Clinical Laboratory Analysis, EarlyView.
– The yearly incidence of anti‐red blood cell antibodies stratified by participant groups and temporal evolution. – Overall significance p = 3.756 × 10−29. ABSTRACT Background Blood transfusion therapies are of vital importance for many patient groups.
Milanka Milosavić, Marko Lilić, Gordana Guzijan, Dušan Vučetić   +3 more
wiley   +1 more source

CD8+ T Cells Negatively Regulate IL-4–Dependent, IgG1-Dominant Posttransplant Alloantibody Production

, 2010
We have previously reported that CD8+ T cells significantly influence Ab production based on the observation that posttransplant alloantibody levels in CD8-deficient murine hepatocyte transplant recipients are markedly enhanced.
Thomas A. Pham, Ginny L. Bumgardner, Virginia M. Sanders, Jason M. Zimmerer   +3 more
core   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Regulation of Alloantibody Responses

Frontiers in Cell and Developmental Biology, 2021
The control of alloimmunity is essential to the success of organ transplantation. Upon alloantigen encounter, naïve alloreactive T cells not only differentiate into effector cells that can reject the graft, but also into T follicular helper (Tfh) cells ...
Anita S. Chong, Peter T. Sage, Maria-Luisa Alegre   +2 more
doaj   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source