Results 51 to 60 of about 4,990 (168)

Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum. [PDF]

, 2023
Antibody profiling is a fundamental component of understanding the humoral response in a wide range of disease areas. Most currently used approaches operate by capturing antibodies onto functionalised surfaces.

core   +2 more sources

Blood transfusion compatibility in patients with delayed serologic transfusion reaction: a retrospective analysis of 6 cases

Zhongguo shuxue zazhi, 2023
Objective To retrospectively analyze the characteristics of blood transfusion compatibility detection in patients with delayed serologic transfusion reaction ( DSTR), in order to provide reference for safe and effective blood transfusion in clinical ...
Jiping XU, Guang YANG, Zhengqiu LIAN, Ling LI   +3 more
doaj   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Evaluation of point‐of‐care versus laboratory antiglobulin‐enhanced major crossmatch testing in cats

Journal of Small Animal Practice, EarlyView.
Objectives It is recommended that all cats, regardless of transfusion history, undergo major crossmatch prior to blood product administration to decrease the likelihood of immunological transfusion reactions. A reliable and user‐friendly point‐of‐care crossmatch test would help make crossmatch testing more accessible.
S. L. Blois, A. J. Collier, S. Sanz, I. Chun   +3 more
wiley   +1 more source

Red blood cell alloimmunization among rhesus D-negative patients in a teaching hospital in Northeastern Malaysia

Asian Journal of Transfusion Science
BACKGROUND: Rhesus D (RhD) negative is considered a rare blood group in Asian country including Malaysia. Thus, the red blood cell (RBC) alloimmunization among RhD negative is considered significant because the blood’s availability and rarity makes it ...
Noorazlina Shaari, Mohd Nazri Hassan, Noor Haslina Mohd Noor, Marini Ramli, Salfarina Iberahim, Zefarina Zulkafli, Shafini Mohamed Yusoff, Rosnah Bahar, Marne Abdullah, Wan Suriana Wan Ab Rahman   +9 more
doaj   +1 more source

A retrospective analysis of the antigen‐negative red blood cell supply conducted at a single centre in China

Transfusion Medicine, EarlyView.
Abstract Objective This study aimed to analyse the distribution and demand patterns of antigen‐negative red blood cells (RBCs) in Shandong Province, China (2022–2024), with a focus on ABO blood groups and clinically significant antigens. The research was designed to provide rigorous data for advancing precision transfusion protocols and to establish a ...
Aiping Zhao, Xiujiao Jiang, Li An, Yuanfeng Chen, Weidong He, Qun Xu, Wenchao Li, Yingfang Pan   +7 more
wiley   +1 more source

Germinal centre alloantibody responses mediate progression of chronic heart allograft injury [PDF]

, 2019
Different profiles of alloantibody responses are observed in the clinic, with those that persist, often despite targeted treatment, associated with poorer long-term transplant outcomes. Although such responses would suggest an underlying germinal centre (
Peacock, S, Alsughayyir, J, Qureshi, MS, Ali, JM, Moseley, EL, Chhabra, M, Goddard, MJ, Mallik, M, Pettigrew, GJ, Kosmoliaptsis, V, Linterman, MA, Motallebzadeh, R, Gamper, I   +12 more
core   +1 more source

Functional validation of a modified platelet desialylation test for immune and hereditary thrombocytopenias

Transfusion Medicine, EarlyView.
Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza, Thamy Caroline Silva, Mateus Domentino, Marina Cavalcanti Albuquerque Veiga Conrado, João Vitor Bernardo Oliveira, Felipe Augusto Rós, Caroline Gabe, Elyse Moritz, Akemi Chiba, Paula Villaça, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Dante Langhi, Carla Luana Dinardo   +14 more
wiley   +1 more source

Hybrid structural modelling of alloantibody binding to human leukocyte antigen with rapid and reproducible cross-linking mass spectrometry (Set 3 of 3)

, 2023
Alloantibody recognition of donor human leukocyte antigen (HLA) is associated with poor clinical transplantation outcomes. However, the molecular and structural basis for the alloantibody-HLA interaction is not well understood.
WANG, Shi Mei, YAP, Jiawei, GU, Yue, GASCOIGNE, Nicholas R.J., LIM, Yan Ting, SER, Zheng, HAMIDINIA, Maryam, MACARY, Paul A., Murali, Tanusya Murali, SOBOTA, Radoslaw M., KUMAR, Ragini   +10 more
core   +1 more source

Simple image analysis for reliability control of column agglutination test in pretransfusion testing

Transfusion Medicine, EarlyView.
Abstract Objectives A novel meniscus‐based analysis provides a rapid method to identify analytical errors related to unrecognised pipetting errors. Background The indirect antihuman globulin test (IAT) is part of pretransfusion testing, enabling detection of erythrocyte alloantibodies.
Martin Töffner Pedersen, Tharisa Rajaguru, Albert Ashong, Ramis Arbi, Niko Hildebrandt, Thor Skovsted   +5 more
wiley   +1 more source