Results 71 to 80 of about 4,990 (168)

Immunoproteasome inhibition reduces donor specific antibody production and cardiac allograft vasculopathy in a mouse heart transplantation model

Frontiers in Transplantation
ObjectiveCardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is one of the leading causes of cardiac transplant failure.
Allison M. Schwalb, Imran Anwar, Isabel DeLaura, Joseph M. Ladowski, Janghoon Yoon, Rafaela Belloni, Mingqing Song, Carolyn Glass, Jun Wang, Stuart Knechtle, Jean Kwun   +10 more
doaj   +1 more source

Pretransfusion testing interference profile of IMC‐002: A novel anti‐CD47 monoclonal antibody engineered for minimized red cell binding

Transfusion, EarlyView.
Abstract Background CD47‐targeted agents can interfere with pretransfusion testing due to CD47 expression on red blood cells (RBCs). IMC‐002 is a novel anti‐CD47 human IgG4 monoclonal antibody engineered to minimize RBC binding; however, its interference profile during pretransfusion testing remains poorly characterized.
Tae‐Shin Kim, Jae Hyeon Park, Yousun Chung, Dae‐Hyun Ko, Seon Young Kim, Hyungsuk Kim   +5 more
wiley   +1 more source

Mapping obstetric biobanks: A scoping review highlighting gaps in the study of alloimmunized pregnancies

Transfusion, EarlyView.
Abstract Background Maternal red cell alloimmunization can cause hemolytic disease of the fetus and newborn (HDFN), yet prediction of disease severity remains limited. Biobanks that link pregnancy biospecimens with clinical and laboratory data could accelerate translational research; however, the landscape of relevant obstetric biobanks has not been ...
Orlin Chowdhury, Chantal Armali, Catherine Devion, Sasha Kyser‐Burke, Akash Gupta, Noor Niyar N. Ladhani, Harley Meirovich, Hubert Tsui, Noah Zweig, Yulia Lin, Heather VanderMeulen   +10 more
wiley   +1 more source

Red blood cell alloantibody titration - Does the titration method matter?

, 2020
Background: Red blood cell (RBC) alloantibody titration is a quasi-quantitative method to assess antibody concentration and is considered a useful means of estimating maternal alloimmunization during pregnancy. Traditionally, titration is performed using
Flesiopoulou, I., Damaskos, C., Pouliakis, A., Soulakis, V., Tsantes, A., Papakonstantinou, M., Dourouki, A., Valsami, S., Politou, M., Koutsouri, T.   +9 more
core   +1 more source

Molecular characterization of CD36 deficiency in blood donors of Middle Eastern and African origin reveals transcript‐level defects beyond genomic variants

Transfusion, EarlyView.
Abstract Background The increasing diversity of blood donor populations has created new challenges for transfusion services worldwide. The identification of donors lacking relevant high‐prevalence antigens is becoming increasingly important to ensure compatible blood products for alloimmunized patients and to support the development of rare donor ...
Sarah Petermann, Inga Stellmacher, Brigitte K. Flesch, Tanja Rehling, Irina Häcker, Marc F. Schetelig, Alexander Carbol, Lambros Kordelas   +7 more
wiley   +1 more source

Data_Sheet_4_Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion.docx

, 2018
Red blood cell (RBC) alloimmunization represents a significant immunological challenge for some patients. While a variety of immune constituents likely contribute to the initiation and orchestration of alloantibodies to RBC antigens, identification of ...
Connie M. Arthur, Kathryn Girard-Pierce (5980175), Connie M. Arthur (5364116), Lilian Cataldi Rodrigues (328771), Megan Fuller (5980184), Jeanne E. Hendrickson, Sean R. Stowell (659895), Satheesh Chonat (5980190), David R. Gibb (5980172), David R. Gibb, Nicole H. Smith, Ryan P. Jajosky (5980181), Nicole H. Smith (5980193), Christopher A. Tormey (5980196), Christopher A. Tormey, Ryan P. Jajosky, Megan Fuller, Seema R. Patel (5364107), Ashley L. Bennett (5980178), Xiaoxi Zhou (288605), Patricia E. Zerra, Cheryl L. Maier (394709), Lilian Cataldi Rodrigues, Ashley L. Bennett, Cheryl L. Maier, Satheesh Chonat, Sean R. Stowell, Patricia E. Zerra (5980187), Xiaoxi Zhou, Jeanne E. Hendrickson (5364113), Kathryn Girard-Pierce, Seema R. Patel   +31 more
core   +1 more source

Implementation of soluble CD38 in blood crossmatching for patients on anti‐CD38 therapy: A single‐center experience

Transfusion, EarlyView.
Abstract Background Human monoclonal (MoAb) anti‐CD38 antibodies, such as daratumumab, are used to treat diseases such as multiple myeloma. Because red blood cells (RBCs) express CD38, these MoAbs interfere with antibody screening and crossmatching in blood banks.
Ayda Javanbakht, David Hanna, Grishma Amatya Jaspau, Ravi Sarode   +3 more
wiley   +1 more source

Data_Sheet_3_Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion.docx

, 2018
Red blood cell (RBC) alloimmunization represents a significant immunological challenge for some patients. While a variety of immune constituents likely contribute to the initiation and orchestration of alloantibodies to RBC antigens, identification of ...
Kathryn Girard-Pierce (5980175), Connie M. Arthur (5364116), Lilian Cataldi Rodrigues (328771), Seema R. Patel (5364107), Ashley L. Bennett (5980178), Megan Fuller (5980184), Xiaoxi Zhou (288605), Sean R. Stowell (659895), Cheryl L. Maier (394709), Satheesh Chonat (5980190), David R. Gibb (5980172), Ryan P. Jajosky (5980181), Nicole H. Smith (5980193), Patricia E. Zerra (5980187), Christopher A. Tormey (5980196), Jeanne E. Hendrickson (5364113)   +15 more
core   +1 more source

A functionally distinct HPA‐1a‐specific alloantibody associated with fetal/neonatal alloimmune thrombocytopenia that activates platelets via FcγRIIa

Transfusion, EarlyView.
Abstract Background Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies directed against fetal platelet antigens, most commonly human platelet antigen‐1a (HPA‐1a). These antibodies mediate platelet destruction and can lead to fetal and neonatal thrombocytopenia severe enough to cause life‐threatening organ bleeds ...
Huiying Zhi, Cathy Paddock, Daniel Villalobos‐Garcia, Janita Oosterhoff, Heng Zhang, Gestur Vidarsson, Renren Wen, Jieqing Zhu, Debra Newman, Peter J Newman   +9 more
wiley   +1 more source

In vivo mechanisms of alloreactivity — IV. Cyclosporine differentially impairs accumulation of donor-reactive CTL but not donor-reactive alloantibody in murine sponge matrix allografts

, 1988
We have studied the influence of Cyclosporine on accumulation of donor-reactive CTL, donor-reactive cytotoxic alloantibody and as an immunosuppressive drug in individual murine sponge matrix allografts.
Charles G. Orosz, Lawrence P. Sirinek, Ferguson, Ronald M., Nancy E. Zinn, Orosz, Charles G., Ronald M. Ferguson, Sirinek, Lawrence P., Zinn, Nancy E.   +7 more
core   +1 more source