Calcium channel α2δ1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. [PDF]
, 2014 To investigate a potential mechanism underlying trigeminal nerve injury-induced orofacial hypersensitivity, we used a rat model of chronic constriction injury to the infraorbital nerve (CCI-ION) to study whether CCI-ION caused calcium channel α2δ1 ...
Kim, Doo-Sik +7 more
core +1 more source
Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation
Neurobiology of Disease, 1998 Postherpetic neuralgia (PHN) is a common and often devastatingly painful condition. It is also one of the most extensively investigated of the neuropathic pains. Patients with PHN have been studied using quantitative testing of primary afferent function,
Howard L. Fields +2 more
doaj +1 more source
Thalamo-cortical network activity between migraine attacks. Insights from MRI-based microstructural and functional resting-state network correlation analysis [PDF]
, 2016 BACKGROUND: Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Here we were aimed to verify functional connectivity between brain networks at rest and its relationship with thalamic microstructure in ...
Colonnese, Claudio +11 more
core +1 more source
Pain Phenotype in Knee Osteoarthritis: Implications for Mechanism‐Based Therapy
Orthopaedic Surgery, EarlyView.The paper reported on the precise and individual treatment of knee osteoarthritis (KOA) pain based on its new classification, including Nociceptive Pain, Neuropathic Pain, and Nociplastic Pain. Tailored treatment recommendations for different types of pain through exploring potential mechanisms of pain in KOA are provided to achieve better clinical ...
Chenchang He +5 more
wiley +1 more source
Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone
Frontiers in Cellular Neuroscience, 2014 A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor ...
Pierrick ePoisbeau +6 more
doaj +1 more source
Veterinary Dermatology, EarlyView.Background: Gabapentin reportedly decreases central sensitisation, a disorder associated with chronic pruritus in humans, although this is not well documented in cats. Its combined use with the standard antipruritic therapy for feline atopic skin syndrome (FASS) is not yet described.
Jeanne Morency +10 more
wiley +1 more source
Allodynia and Pinprick Hypesthesia in Acute Herpes Zoster, and the Development of Postherpetic Neuralgia [PDF]
, 2000 Maija Haanpää +2 more
openalex +1 more source
Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.Abstract Aim The pathophysiology and treatment of sensory hypersensitivity remain unclear. This study aimed to identify a simple behavioral analysis device and animal model evaluating glare sensitivity and to test the effects of psychotropic drugs using this device.
Shogo Hirota +7 more
wiley +1 more source
Antagonism of the Melanocortin System Reduces Cold and Mechanical Allodynia in Mononeuropathic Rats [PDF]
, 2000 Dorien H. Vrinten +3 more
openalex +1 more source
Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients. [PDF]
, 2020 ObjectivesTo evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis.MethodsIn a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen ...
Abouzari, Mehdi +7 more
core