Results 21 to 30 of about 30,446 (212)

Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice

Cells, 2023
Background: Transient receptor potential ankyrin 1 (TRPA1) activation is implicated in neuropathic pain-like symptoms. However, whether TRPA1 is solely implicated in pain-signaling or contributes to neuroinflammation in multiple sclerosis (MS) is unknown.
Diéssica Padilha Dalenogare, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Mustafa Titiz, Gaetano De Siena, Francesco De Logu, Pierangelo Geppetti, Romina Nassini, Gabriela Trevisan   +8 more
doaj   +1 more source

C/EBPβ Contributes to Cancer-Induced Bone Pain by Inhibiting CD200/CD200R1 in the Spinal Cord. [PDF]

CNS Neurosci Ther
Patients with advanced cancer continue to endure severe bone pain, for which current therapeutic options remain inadequate. Spinal microglial activation and subsequent neuroinflammation constitute key pathological mechanisms underlying cancer‐induced bone pain (CIBP).
Li DY, Liu L, Liu DQ, Zhang LQ, Zhou YQ, Mei W.   +5 more
europepmc   +2 more sources

Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice

Journal of Traditional and Complementary Medicine, 2014
Peripheral neuropathy is a major dose-limiting side effect of the chemotherapeutic agent paclitaxel. This study examined whether the three related traditional herbal formulations, goshajinkigan (GJG; 牛車腎氣丸 Niú Chē Shèn Qì Wán), hachimijiogan (HJG; 八味地黃丸 ...
Tsugunobu Andoh, Ryo Kitamura, Hirotoshi Fushimi, Katsuko Komatsu, Naotoshi Shibahara, Yasushi Kuraishi   +5 more
doaj   +1 more source

Dietary Supplementation with Palmitoyl-Glucosamine Co-Micronized with Curcumin Relieves Osteoarthritis Pain and Benefits Joint Mobility

Animals, 2020
Chronic mixed pain and orthopedic dysfunction are the most frequently associated consequences of canine osteoarthritis (OA). An unmet need remains for safe and effective therapies for OA.
Enrico Gugliandolo, Alessio Filippo Peritore, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Ramona D’Amico, Rosanna Di Paola, Carlo Schievano, Salvatore Cuzzocrea, Rosalia Crupi   +10 more
doaj   +1 more source

Pregabalin–Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats

Pharmaceuticals, 2023
The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed.
Nariman Essmat, Anna Rita Galambos, Péter P. Lakatos, Dávid Árpád Karádi, Amir Mohammadzadeh, Sarah Kadhim Abbood, Orsolya Geda, Rudolf Laufer, Kornél Király, Pál Riba, Zoltán S. Zádori, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani   +13 more
doaj   +1 more source

Effects of onabotulinumtoxinA treatment in patients with and without allodynia: results of the COMPEL study

The Journal of Headache and Pain, 2019
Background OnabotulinumtoxinA is effective in treating chronic migraine (CM), but there are limited data assessing how allodynia affects preventive treatment responses.
William B. Young, J. Ivan Lopez, John F. Rothrock, Amelia Orejudos, Aubrey Manack Adams, Richard B. Lipton, Andrew M. Blumenfeld   +6 more
doaj   +1 more source

Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia

Molecular Pain, 2007
Background The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult.
Cervero Fernando, Entrena Jose M, Price Theodore J, Pitcher Mark H   +3 more
doaj   +1 more source

The Spicy Story of Cannabimimetic Indoles

Molecules, 2021
The Sterling Research Group identified pravadoline as an aminoalkylindole (AAI) non-steroidal anti-inflammatory pain reliever. As drug design progressed, the ability of AAI analogs to block prostaglandin synthesis diminished, and antinociceptive activity
Allyn C. Howlett, Brian F. Thomas, John W. Huffman   +2 more
doaj   +1 more source

Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats

Journal of Pharmacological Sciences, 2018
Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in ...
Shota Yamamoto, Nobuaki Egashira, Makoto Tsuda, Satohiro Masuda   +3 more
doaj   +1 more source

Neuropathic Pain: Mechanism, Representation, Management and Treatment

International Clinical Neuroscience Journal, 2022
Despite the development of screening tests and diagnostic tools, neuropathic pain is still identified as an underdiagnosed condition lacking proper epidemiological studies. It is difficult to estimate its incidence and prevalence the population.
Amir Saied Seddighi, Afsoun Seddighi, Mahsa Ghadirian, Alireza Zali, Seyed Mahmoud Tabatabaei Far   +4 more
doaj   +1 more source