Results 81 to 90 of about 66,158 (349)

Tattoo sarcoidosis presenting as abdominal allodynia

Medical Journal of Australia, 2022
A 40-year-old man was referred with left-sided abdominal pain (described as “like broken-glass”) radiating across his abdomen, arthralgias and a mild ileitis endoscopically (not histologically). Clinical examination revealed abdominal allodynia and a focally raised, firm and oedematous tattoo (Figure, A).
Faint, Annabelle, Daveson, A. James M.
openaire   +3 more sources

Animal models of cisplatin‐induced neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li, Mingzhu Li, Shengbo Jin, Jun Yu, Hongzhe Wei, Wenping Wang, Siyao Ma, Yuxin Jiang, Qian Liu, Huini Yao   +9 more
wiley   +1 more source

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

Molecular Pain, 2011
Background Fibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established
Mukae Takehiro, Araki Kohei, Nagai Jun, Uchida Hitoshi, Nishiyori Michiko, Kishioka Shiroh, Ueda Hiroshi   +6 more
doaj   +1 more source

Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice

Antioxidants, 2022
Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated.
Santiago Coral-Pérez, Ignacio Martínez-Martel, Maria Martínez-Serrat, Gerard Batallé, Xue Bai, Christie R. A. Leite-Panissi, Olga Pol   +6 more
doaj   +1 more source

Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer

Molecular Pain, 2018
Chronic pain induced by nerve damage due to trauma or invasion of cancer to the bone elicits severe ongoing pain as well as hyperalgesia and allodynia likely reflecting adaptive changes within central circuits that amplify nociceptive signals.
Moe Watanabe, Michiko Narita, Yusuke Hamada, Akira Yamashita, H. Tamura, D. Ikegami, T. Kondo, Tatsuto Shinzato, Takatsune Shimizu, Y. Fukuchi, A. Muto, H. Okano, A. Yamanaka, V. Tawfik, N. Kuzumaki, E. Navratilova, F. Porreca, M. Narita   +17 more
semanticscholar   +1 more source

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

Annals of Neurology, EarlyView.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim, Manyoel Lim, Thiago D. Nascimento, Frank Porreca, Robert A. Koeppe, Nouchine Hadjikhani, Alexandre F. DaSilva   +6 more
wiley   +1 more source

Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]

, 2015
Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine, Ramachandran, Roshni, Yaksh, Tony L   +2 more
core   +2 more sources

Pharmacological Differences Between Static and Dynamic Allodynia in Mice With Herpetic or Postherpetic Pain

Journal of Pharmacological Sciences, 2008
In the present study, we investigated whether dynamic and static allodynia would be developed in the affected dermatome in murine models of herpetic pain and postherpetic neuralgia and pharmacologically characterized the allodynia.
Atsushi Sasaki, Kenichi Serizawa, Tsugunobu Andoh, Kimiyasu Shiraki, Hiroki Takahata, Yasushi Kuraishi   +5 more
doaj  

Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy

Advanced NanoBiomed Research, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali, Rocco Latorre, Raquel Tonello, David Poolman, Suwan Ding, Brian L. Schmidt, Nigel W. Bunnett, Kam W. Leong   +7 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source