Results 81 to 90 of about 52,858 (307)

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Proton pump inhibitor concomitant use to prevent oxaliplatin‐induced peripheral neuropathy: Clinical retrospective cohort study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Oxaliplatin‐induced peripheral neuropathy (OIPN) is a major clinical challenge because it leads to discontinuation of chemotherapy. Omeprazole, a proton pump inhibitor (PPI), has been shown to prevent OIPN in a rat model. Therefore, we aimed to test whether the concomitant use of a PPI reduces oxaliplatin discontinuation due to OIPN.
Keisuke Mine, Takehiro Kawashiri, Kohei Mori, Yusuke Mori, Haruna Ishida, Hibiki Kudamatsu, Shunsuke Fujita, Mayako Uchida, Takaaki Yamada, Nobuaki Egashira, Ichiro Ieiri, Satoru Koyanagi, Shigehiro Ohdo, Takao Shimazoe, Daisuke Kobayashi   +14 more
wiley   +1 more source

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Beyond Pain Relief: Unveiling the Multifaceted Impact of Anti-CGRP/R mAbs on Comorbid Symptoms in Resistant Migraine Patients

Biomedicines
The study aimed to evaluate the effects of monoclonal antibodies (mAbs) acting on the calcitonin gene-related peptide (CGRP) or its receptor (anti-CGRP/R mAbs) on migraine comorbidities of depression, anxiety, and fatigue in patients resistant to ...
Alessandra Della Vecchia, Ciro De Luca, Lucrezia Becattini, Letizia Curto, Elena Ferrari, Gabriele Siciliano, Sara Gori, Filippo Baldacci   +7 more
doaj   +1 more source

Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain

Frontiers in Physiology, 2017
Abnormal Ca2+ channel physiology, expression levels, and hypersensitivity to heat have been implicated in several pain states following treatment with chemotherapeutic agents.
Mustafa Nazıroğlu, Nady Braidy
doaj   +1 more source

Physical function and perceived pain following inpatient intensive interdisciplinary pain treatment for children and adolescents

PM&R, EarlyView.
Abstract Background Chronic pain among children and adolescents negatively impacts overall functioning and quality of life. Although Intensive Interdisciplinary Pain Treatment (IIPT) programs aim to reduce functional impairment and perceived pain, overall evidence is limited and restricted by small sample sizes and limited diversity in pain diagnoses ...
Mayank Seth, Kate Vieni, Kathryn Hottinger, Katherine Bentley   +3 more
wiley   +1 more source

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice [PDF]

, 2014
OBJECTIVE: Osteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal ...
Bevan, S, Chang, Y M, De Souza, R, Fed Mato Grosso, Gentry, C, King's, Knights, C B, Pitsillides, A A, Poulet, B, UCL, Wilson, A M   +10 more
core   +4 more sources

Dietary Supplementation with Palmitoyl-Glucosamine Co-Micronized with Curcumin Relieves Osteoarthritis Pain and Benefits Joint Mobility

Animals, 2020
Chronic mixed pain and orthopedic dysfunction are the most frequently associated consequences of canine osteoarthritis (OA). An unmet need remains for safe and effective therapies for OA.
Enrico Gugliandolo, Alessio Filippo Peritore, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Ramona D’Amico, Rosanna Di Paola, Carlo Schievano, Salvatore Cuzzocrea, Rosalia Crupi   +10 more
doaj   +1 more source

What is all the noise about pain management? Analgesia in cases of noise fear related to discomfort can reduce the need for extensive training plans

Veterinary Record Case Reports, EarlyView.
Abstract A 6‐year‐old, male, entire Jack Russell terrier was referred for noise fear and subsequently diagnosed with underlying musculoskeletal discomfort. Significant improvements in the signs were reported by the clients by initially addressing the underlying discomfort using a combination of analgesia (1.7 mg/kg carprofen once a day), environmental ...
Beverley M. Wilson, Daniel S. Mills
wiley   +1 more source

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source