Results 81 to 90 of about 30,446 (212)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, Volume 38, Issue 4, Page 220-228, April 2026.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Nationwide Survey of Atopic Myelitis and Plexin D1‐Immunoglobulin G‐Related Pain

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 593-606, March 2026.
ABSTRACT Objective To elucidate the features of plexin D1‐immunoglobulin (Ig)G‐associated neuropathic pain and its relationship to atopic myelitis (AM) in a nationwide Japanese survey. Methods A preliminary survey questionnaire was sent to 1574 selected departments (neurology and pediatrics/pediatric neurology) to explore the numbers of AM and plexin ...
Jun‐ichi Kira, Xu Zhang, Takayuki Fujii, Mikio Mitsuishi, Miho Ushijima, Sato Yoshidomi, Ayako Sakoda, Tomohiro Imamura, Satoshi Kuwabara, Noriko Isobe, Yuri Nakamura   +10 more
wiley   +1 more source

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

Severe Postpartum Inguinal Neuralgia Relieved by Ultrasound‐Guided Nerve Blocks: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Postpartum groin pain is common, but neuropathic pain caused by injury to the ilio‐inguinal, iliohypogastric, or genitofemoral nerves is rarely described and may be overlooked. We present the case of a 33‐year‐old breastfeeding woman who developed excruciating left inguinal pain that began shortly before a Pfannenstiel cesarean section and ...
Dan Sebastian Dirzu, Carmen Bianca Crivii   +1 more
wiley   +1 more source

Effects of Tetrodotoxin on Safety, and Sensory and Respiratory Systems: A Dose‐Escalating Study in Healthy Volunteers

European Journal of Pain, Volume 30, Issue 3, March 2026.
ABSTRACT Background Chronic pain affects approximately 1.5 billion individuals worldwide, and currently available treatments often fail to provide adequate analgesia. Consequently, there is a need to explore novel analgesic compounds, including tetrodotoxin.
Kiki W. K. Kuijpers, Rutger Van Der Schrier, Albert Dahan, Monique Van Velzen   +3 more
wiley   +1 more source

Bedside Neuromodulation of Persistent Pain and Allodynia with Caloric Vestibular Stimulation

Biomedicines
Background: Caloric vestibular stimulation (CVS) is a well-established neurological diagnostic technique that also induces many phenomenological modulations, including reductions in phantom limb pain (PLP), spinal cord injury pain (SCIP), and central ...
Trung T. Ngo, Wendy N. Barsdell, Phillip C. F. Law, Carolyn A. Arnold, Michael J. Chou, Andrew K. Nunn, Douglas J. Brown, Paul B. Fitzgerald, Stephen J. Gibson, Steven M. Miller   +9 more
doaj   +1 more source

A Freshwater Pearl Mussel Polysaccharide Alleviates Inflammatory Pain by Targeting Peripheral Cytokines and Spinal Astroglial NLRP3/GFAP Responses

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Mussel polysaccharide (MP), a novel food resource from pearl mussels, alleviates inflammatory pain in rats in a dose‐dependent manner. It acts by dually inhibiting peripheral inflammation (reducing paw swelling and pro‐inflammatory cytokines) and spinal neuroinflammation via the NLRP3 and astrocyte pathway.
Chen Hu, Weiwei Xu, Yingjian Zhu, Yushan He, Jiayuan Xu, Xiaomei Wang, Furong Niu, Guangming Chen, Hongchang Zhou   +8 more
wiley   +1 more source

Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis

Glia, Volume 74, Issue 3, March 2026.
Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Amelia Trimarco, Matteo Audano, Rosa La Marca, Marta Pellegatta, Paolo Canevazzi, Mariaconcetta Cariello, Marta Falco, Silvia Pedretti, Gabriele Imperato, Alessandro Cestaro, Paola Podini, Giorgia Dina, Angelo Quattrini, Luca Massimino, Donatella Caruso, Nico Mitro, Carla Taveggia   +16 more
wiley   +1 more source

Hell's Itch: An Acute Reaction to Sunburn Exposure

JEADV Clinical Practice, Volume 5, Issue 1, Page 234-236, March 2026.
ABSTRACT Hell's itch is a neurocutaneous dysesthesia following sunburn that is underreported in scientific literature despite considerable discussion online. ‘Hell's itch’ describes an acute, uncontrollable itch with intense stabbing pain several days post‐sunburn and often follows an inciting event such as water exposure.
Colin Kelly, Connor Stonesifer, Brian W. Morrison   +2 more
wiley   +1 more source