Results 81 to 90 of about 32,744 (263)

Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone

Frontiers in Cellular Neuroscience, 2014
A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor ...
Pierrick ePoisbeau, Florence eKeller, Florence eKeller, Maya eAouad, Nisrine eKamoun, Ghislaine eGroyer, Michael eSchumacher   +6 more
doaj   +1 more source

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin [PDF]

, 2016
José Manuel Entrena, Cristina Sánchez–Fernández, Francisco R. Nieto, Rafael González‐Cano, Sandra Yeste, Enrique J. Cobos, José M. Baeyens   +6 more
openalex   +1 more source

Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene‐related peptide sensitization

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The aim of this study was to determine the photoreceptor basis of light avoidance in mice and assess the effect of CGRP sensitization on this behavior. Background Prior studies have suggested that photophobia is mediated by a subset of retinal ganglion cells (RGCs) that contain melanopsin, making them intrinsically photosensitive ...
Eric A. Kaiser, Audrey Cavanah, Geoffrey K. Aguirre, Frances E. Jensen   +3 more
wiley   +1 more source

Bilateral mechanical and thermal hyperalgesia and tactile allodynia after chronic compression of dorsal root ganglion in mice [PDF]

, 2011
Ronggui Chen, Weiwei Kong, Da-Long Ge, Ceng Luo, San-Jue Hu   +4 more
openalex   +1 more source

Administration of the Sleep‐Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia

Journal of Sleep Research, EarlyView.
ABSTRACT Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood.
Viviane S. Hambrecht‐Wiedbusch, Angelo V. Colmenero, Alejandra Mondino, Graciela Mentz, Steven E. Harte, Giancarlo Vanini   +5 more
wiley   +1 more source

Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti‐inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia [PDF]

, 2012
Jenny L. Wilkerson, Katherine R. Gentry, Ellen C. Dengler, James A. Wallace, Audra A. Kerwin, Megan Kuhn, A. M. Zvonok, Ganesh A. Thakur, Alexandros Makriyannis, Erin D. Milligan   +9 more
openalex   +1 more source

Differences in Plasma Exposure of Cannabidiol and Cannabidiolic Acid Following Oral Administration to Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT There has been a growing interest in the use of cannabinoids in horses in recent years. Several studies have reported on the pharmacokinetics of cannabidiol (CBD) in horses. However, cannabidiolic acid (CBDA) has received less attention, despite limited evidence suggesting clinically beneficial effects in other species.
Carl Ekstrand, Peter Michanek, Elin Hernlund, Ronette Gehring, Kristin Spjut, Matilda Salomonsson   +5 more
wiley   +1 more source

Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice

, 2020
Jacob R. Bumgarner, William H. Walker, Jennifer A. Liu, James C. Walton, Randy J. Nelson   +4 more
openalex   +2 more sources

Metabotropic glutamate receptor 5‐mediated inhibition of inward‐rectifying K ⁺ channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice [PDF]

, 2023
Yike Li, Yanyan Zhang, Jiu Lin, Yajing Liu, Yueling Li, Yu‐Heng Feng, Jiashuo Zhao, Cheng Zhou, Fei Liu, Jiefei Shen   +9 more
openalex   +1 more source

The Development of Mechanical Allodynia in Diabetic Rats Revealed by Single-Cell RNA-Seq

, 2022
Han Zhou, Xiaosheng Yang, Chenlong Liao, Hongjin Chen, Yiwei Wu, Binran Xie, Fukai Ma, WenChuan Zhang   +7 more
openalex   +1 more source