Results 1 to 10 of about 9,102 (145)

Not as “D”eadly as once thought – the risk of D-alloimmunization and hemolytic disease of the fetus and newborn following RhD-positive transfusion in trauma

Hematology, 2023
The use of blood products to resuscitate injured and massively bleeding patients in the prehospital and early in-hospital phase of the resuscitation is increasing.
M. Yazer, G. Panko, J. Holcomb, Alesia Kaplan, Christine M. Leeper, J. Seheult, D. Triulzi, P. Spinella   +7 more
semanticscholar   +1 more source

Prior Immunization to an Intracellular Antigen Enhances Subsequent Red Blood Cell Alloimmunization in Mice.

Blood, 2023
Antibodies to red blood cell (RBC) alloantigens can increase morbidity and mortality in transfusion recipients. However, alloimmunization rates can vary dramatically, with some patients never generating alloantibodies following transfusion, while others ...
R. Jajosky, S. Patel, Shang-Chuen Wu, K. Patel, M. Covington, M. Vallecillo-Zúniga, Diyoly Ayona, Ashley Bennett, C. J. Luckey, K. Hudson, J. Hendrickson, Stepahanie C Eisenbarth, C. Josephson, P. Zerra, S. Stowell, C. Arthur   +15 more
semanticscholar   +1 more source

Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice

Transfusion, 2023
The impact of blood storage on red blood cell (RBC) alloimmunization remains controversial, with some studies suggesting enhancement of RBC‐induced alloantibody production and others failing to observe any impact of storage on alloantibody formation ...
C. Maier, R. Jajosky, S. Patel, H. Verkerke, Megan D Fuller, J. W. Allen, P. Zerra, R. Fasano, S. Chonat, C. Josephson, D. Gibb, S. Eisenbarth, C. J. Luckey, K. Hudson, J. Hendrickson, C. Arthur, S. Stowell   +16 more
semanticscholar   +1 more source

Proinflammatory state promotes red blood cell alloimmunization in pediatric patients with sickle cell disease

Blood Advances, 2023
Key Points • Transfusion during proinflammatory events increases alloimmunization in patients with sickle cell disease, which is not mitigated by HU.• High transfusion burden and HbSS and HbSβ0–thalassemia genotypes are additional risk factors for ...
Yan Zheng, J. Gossett, Pei-Lin Chen, Martha Barton, M. Ryan, Jing Yu, G. Kang, J. Hankins, S. Chou   +8 more
semanticscholar   +1 more source

The Development and Consequences of Red Blood Cell Alloimmunization

Annual Review of Pathology, 2022
While red blood cell (RBC) transfusion is the most common medical intervention in hospitalized patients, as with any therapeutic, it is not without risk.
C. Arthur, S. Stowell
semanticscholar   +1 more source

Incidence of anti‐D alloimmunization in D‐negative individuals receiving D‐positive red blood cell transfusion: A systematic review and meta‐analysis

Vox Sanguinis, 2022
The transfusion of D‐negative red blood cells (RBCs) to D‐negative patients has been widely adopted to prevent anti‐D alloimmunization, especially in women of childbearing age.
Yanli Ji, G. Luo, Yongshui Fu
semanticscholar   +1 more source

Pathophysiology of Alloimmunization [PDF]

Transfusion Medicine and Hemotherapy, 2019
<b><i>Introduction:</i></b> Alloimmunization is caused by exposure to erythrocytes from a donor that expresses blood group antigens other than those of the recipient and is related to processes that alter the balance of the immune system. Knowing the pathophysiology of alloimmunization process is essential to understand clinical
Soledad Gómez-Ruiz, Jorge Vela-Ojeda, Jorge Vela-Ojeda, Laura Montiel-Cervantes, Laura Montiel-Cervantes, Rubiraida Molina-Aguilar, Rubiraida Molina-Aguilar, Elba Reyes-Maldonado   +7 more
openaire   +3 more sources

Rate of D‐alloimmunization in trauma does not depend on the number of RhD‐positive units transfused: The BEST collaborative study

Transfusion, 2022
Evidence indicates the life‐saving benefits of early blood product transfusion in severe trauma resuscitation. Many of these products will be RhD‐positive, so understanding the D‐alloimmunization rate is important.
J. Seheult, J. Callum, M. Delaney, Rosanna Drake, N. Dunbar, S. Harm, J. R. Hess, Bryon P Jackson, A. Javanbakht, S. Moore, Melissa S. Murphy, J. Raval, J. Staves, Erin E Tuott, S. Wendel, A. Ziman, M. Yazer   +16 more
semanticscholar   +1 more source

Red blood cell alloimmunization among recipients of blood transfusion in India: A systematic review and meta‐analysis

Vox Sanguinis, 2022
There is a varied prevalence of red cell alloimmunization being reported from different parts of India. This study aimed to estimate the overall prevalence of alloimmunization in India by performing a systematic review of the literature and to establish ...
S. Shastry, Deepika Chenna, A. Basavarajegowda, Soumya Das, R. Chaudhary   +4 more
semanticscholar   +1 more source

Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice

Transfusion, 2022
Alloimmunization can be a significant barrier to red blood cell (RBC) transfusion. While alloantigen matching protocols hold promise in reducing alloantibody formation, transfusion‐dependent patients can still experience RBC alloimmunization and ...
C. Arthur, S. Patel, Asish Sharma, P. Zerra, S. Chonat, R. Jajosky, R. Fasano, Ravindra K. Patel, Ashley Bennett, Xiaoxi Zhou, C. J. Luckey, K. Hudson, S. Eisenbarth, C. Josephson, J. Roback, J. Hendrickson, S. Stowell   +16 more
semanticscholar   +1 more source