Results 1 to 10 of about 10,210 (217)

Platelet alloimmunization in transfusion-dependent thalassemia patients from Southern China (2014-2023) [PDF]

Frontiers in Immunology
Patients with transfusion-dependent thalassemia (TDT) are at high risk of alloimmunization. While previous research is predominantly focused on red blood cell alloimmunization, the potential risks of platelet alloimmunization are frequently ...
Yuchen Huang, Yuxi Chen, Qiuhong Mo, Huihui Mo, Fang Lu, Hengcong Li, Lilan Li, Jierun Chen, Lihong Jiang, Yan Zhou, Zhoulin Zhong   +10 more
doaj   +2 more sources

Red Cell Alloimmunization Among Transfused Chronic Kidney Disease Patients: A Hospital-Based Study in Southwestern Uganda [PDF]

Journal of Blood Medicine
Elizabeth A John,1 Enoch Muwanguzi,1 Robert Wagubi,1 Simon Peter Rugera,1 Charles Nkubi Bagenda,1 Rose Muhindo,2 Benson Okongo1 1Department of Medical Laboratory Science, Mbarara University of Science and Technology, Mbarara City, Uganda; 2Department of ...
John EA, Muwanguzi E, Wagubi R, Rugera SP, Bagenda CN, Muhindo R, Okongo B   +6 more
doaj   +2 more sources

Impact of HLA alloimmunization on clinical outcomes of severe aplastic anemia treated with immunosuppressive therapy [PDF]

Blood Advances
: Immune aplastic anemia (iAA) frequently results in transfusion dependence on platelets and packed red blood cells, increasing the risk for complications.
Jibran Durrani, Leonard N. Chen, Ruba N. Shalhoub, Valentina Baez, Joshua Glass, Nu Ri Cha, Xiaoyang Ma, Zhijie Wu, Shouguo Gao, Jennifer Lotter, Olga Rios, Colin O. Wu, Willy A. Flegel, Neal S. Young, Emma M. Groarke, Bhavisha A. Patel   +15 more
doaj   +2 more sources

The Nrf2 Activator CDDO-Imidazole Suppresses Inflammation-Induced Red Blood Cell Alloimmunization [PDF]

Antioxidants
Experimental Objective: During red blood cell (RBC) transfusion, inflammation promotes the production of anti-RBC alloantibodies that can cause significant hemolytic events.
Che-Yu Chang, Rosario Hernández-Armengol, Kausik Paul, June Young Lee, Karina Nance, Tomohiro Shibata, Peibin Yue, Christian Stehlik, David R. Gibb   +8 more
doaj   +2 more sources

RBC Alloimmunization in Sudanese Multi-transfused Patients [PDF]

Journal of Bioscience and Applied Research, 2020
Background: Blood transfusions are a life-saving measure to replace blood lost through severe bleeding or as a life-saving treatment for various hematological conditions. Blood transfusions are high-risk procedures. One of these risks is alloimmunization.
Hager Elkobani, Sahar Elbager, Magdi Bayoumi   +2 more
doaj   +1 more source

FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization

Frontiers in Immunology, 2022
Passive immunization with anti-D can prevent maternal alloimmunization to RhD thereby preventing hemolytic disease of the fetus and newborn. Unexpectedly, anti-D fails in some cases and some monoclonal anti-D preparations paradoxically enhances ...
Annie Qiu, Anabel Miller, Flavia Dei Zotti, Manjula Santhanakrishnan, Jeanne E. Hendrickson, Maria Tredicine, Sean R. Stowell, Chance John Luckey, James C. Zimring, James C. Zimring, Krystalyn E. Hudson   +10 more
doaj   +1 more source

Alloimmunization to erythrocyte antigens in patients receiving multiple blood transfusions: Clinico-immunohematological and demographic risk factors and impact of extended red cell phenotyping

Global Journal of Transfusion Medicine, 2021
Background and Objectives: The risk of red blood cell (RBC) alloimmunization is always a concern for multi-transfused patients. Various factors have been found to be associated with alloimmunization. Alloimmunization rates were reported from 4% to 50%, 1.
Sudipta Sekhar Das, Rathindra Nath Biswas, Mahammad Safi, Rafique Uz Zaman   +3 more
doaj   +1 more source

Red Blood Cell Alloimmunization and Its Associated Factors among Chronic Liver Disease Patients in a Teaching Hospital in Northeastern Malaysia

Diagnostics, 2023
Red blood cell (RBC) alloimmunization is an important complication of blood transfusion. Variations in the frequency of alloimmunization have been noted among different patient populations. We aimed to determine the prevalence of RBC alloimmunization and
Siti Zaleha S. Abdullah, Mohd Nazri Hassan, Marini Ramli, Marne Abdullah, Noor Haslina Mohd Noor   +4 more
doaj   +1 more source

Factors influencing transfusion-associated HLA sensitization in patients bridged to heart transplantation using ventricular assist device. [PDF]

, 2020
BackgroundBridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti-HLA antibodies associated with rejection of subsequent allografts ...
Adler, Eric, Elkind, Jae, Morris, Gerald P, Ostberg-Braun, Oscar, Silva Enciso, Jorge, Sobczyk, Juliana   +5 more
core   +1 more source

Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia

Anemia, 2023
Introduction. The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients.
Fahd A. Kuriri, Abdulrahman Ahmed, Fehaid Alanazi, Fahad Alhumud, Mohammed Ageeli Hakami, Osama Atiatalla Babiker Ahmed   +5 more
doaj   +1 more source