Results 91 to 100 of about 14,033 (212)

Hemolysis Inhibits Humoral B Cell Responses and Modulates Alloimmunization Risk in Patients with Sickle Cell Disease.

Blood, 2020
Red blood cell alloimmunization remains a barrier for safe and effective transfusions in sickle cell disease (SCD), but the associated risk factors remain largely unknown.
M. Pal, Weili Bao, Rikang Wang, Yunfeng Liu, X. An, W. Mitchell, C. Lobo, C. Minniti, Patricia A. Shi, D. Manwani, K. Yazdanbakhsh, H. Zhong   +11 more
semanticscholar   +1 more source

Scaling of prehospital blood: A model describing impact on U.S. blood donors, distribution and cost

Transfusion, EarlyView.
Abstract Background Prehospital transfusion improves survival in traumatic and medical hemorrhage, but the blood supply implications of scaling this capability across U.S. emergency medical services (EMS) systems are unclear. Study Design and Methods We developed an analytic model incorporating national estimates of prehospital transfusion demand, EMS ...
Pampee P. Young, David Wood, John B. Holcomb, Donald H. Jenkins, Matthew J. Levy   +4 more
wiley   +1 more source

Free Fetal DNA Testing to Guide Early Intervention in the Management of the Kell Alloimmunized Pregnancy

Prenatal Diagnosis, EarlyView.
Kenneth J. Moise Jr, Thomas Trevett, Stephanie Moench, Erin Moise   +3 more
wiley   +1 more source

A global survey of blood transfusion practices for patients with sickle cell disease

Transfusion, EarlyView.
Abstract Background Sickle cell disease (SCD) affects over 7 million people globally, with blood transfusion remaining a cornerstone of management. However, contemporary transfusion practices across diverse settings remain poorly characterized. We evaluated global transfusion practices for patients with SCD to identify gaps and inform resource ...
Jeremy W. Jacobs, Arwa Z. Al‐Riyami, Jeannie Callum, Meghan Delaney, David Daniel, Jenny White, Christopher Bocquet, Mohammed Farouk, Claude Tayou, Chinelo P. Onyenekwu, Kristina Prus, Divjot Singh Lamba, Julie Makani, Quentin Eichbaum, Luiz Amorim, Silvano Wendel, France Pirenne, Vernon Louw, Evan M. Bloch   +18 more
wiley   +1 more source

From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

, 2014
Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to ...
Chaker Aloui, Sandrine Laradi, Nicolas Maillard, Christophe Mariat, Fabrice Cognasse, Olivier Garraud, Antoine Prigent, Léna Absi   +7 more
core   +1 more source

Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS-III) database

British Journal of Haematology, 2018
Despite the significance of red blood cell (RBC) alloimmunization, the lack of standardized registries in the US has prevented the completion of large studies.
M. Karafin, Matt Westlake, R. Hauser, C. Tormey, P. Norris, Nareg H. Roubinian, Yan-Yun Wu, D. Triulzi, S. Kleinman, J. Hendrickson   +9 more
semanticscholar   +1 more source

Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine

Advances in Hematology, 2018
Background. Transfusion of red blood cells (RBC) is an essential therapeutic tool in sickle cell disease (SCD). Repeated RBC transfusions can cause alloimmunization which causes difficulty in cross-matching and finding compatible blood for transfusions ...
Fekri Samarah, Mahmoud A. Srour, Dirgham Yaseen, Kamal Dumaidi   +3 more
doaj   +1 more source

Prenatal treatment of severe fetal hemolytic disease due to anti-M alloimmunization by serial intrauterine transfusions

Taiwanese Journal of Obstetrics & Gynecology, 2017
Objective: Fetal hemolytic disease is a common cause of fetal hydrops and fetal morbidity and mortality. Despite its relatively low frequency, the anti-M IgG antibody is one of the causes of severe fetal anemia and intrauterine death; only a few cases ...
Lin Li, Linhuan Huang, Guangping Luo, Yanmin Luo, Qun Fang   +4 more
doaj   +1 more source

Mapping obstetric biobanks: A scoping review highlighting gaps in the study of alloimmunized pregnancies

Transfusion, EarlyView.
Abstract Background Maternal red cell alloimmunization can cause hemolytic disease of the fetus and newborn (HDFN), yet prediction of disease severity remains limited. Biobanks that link pregnancy biospecimens with clinical and laboratory data could accelerate translational research; however, the landscape of relevant obstetric biobanks has not been ...
Orlin Chowdhury, Chantal Armali, Catherine Devion, Sasha Kyser‐Burke, Akash Gupta, Noor Niyar N. Ladhani, Harley Meirovich, Hubert Tsui, Noah Zweig, Yulia Lin, Heather VanderMeulen   +10 more
wiley   +1 more source

The Nrf2 Activator CDDO-Imidazole Suppresses Inflammation-Induced Red Blood Cell Alloimmunization

Antioxidants
Experimental Objective: During red blood cell (RBC) transfusion, inflammation promotes the production of anti-RBC alloantibodies that can cause significant hemolytic events.
Che-Yu Chang, Rosario Hernández-Armengol, Kausik Paul, June Young Lee, Karina Nance, Tomohiro Shibata, Peibin Yue, Christian Stehlik, David R. Gibb   +8 more
doaj   +1 more source