Research progress in RBC alloimmunization [PDF]
Frontiers in ImmunologyRed blood cell (RBC) alloimmunization is a common and clinically significant immunological phenomenon in transfusion medicine, pregnancy management, and organ transplantation.
Zike Fu, Xinxin Hao, Wa Gao, Quishi Wang
exaly +4 more sources
FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization [PDF]
Frontiers in Immunology, 2022 Passive immunization with anti-D can prevent maternal alloimmunization to RhD thereby preventing hemolytic disease of the fetus and newborn. Unexpectedly, anti-D fails in some cases and some monoclonal anti-D preparations paradoxically enhances ...
Annie Qiu +10 more
doaj +2 more sources
Type 1 Interferon Gene Signature Promotes RBC Alloimmunization in a Lupus Mouse Model [PDF]
Frontiers in Immunology, 2020 Red blood cell (RBC) transfusion exposes recipients to hundreds of unmatched minor RBC antigens. This exposure can lead to production of alloantibodies that promote clinically significant hemolytic events.
June Young Lee +8 more
doaj +2 more sources
Transfusion and Apheresis Science, 2023 Background and aims: As the alloimmunization remains a major complication associated with RBC transfusions in SCD patients and can be associated with Delayed Hemolytic Transfusion Reactions (DHTRs), this study was undertaken to assess the effects of ...
Lilian Castilho
exaly +3 more sources
Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice [PDF]
The Journal of Clinical InvestigationAdministration of anti-RhD immunoglobulin (Ig) to decrease maternal alloimmunization (antibody-mediated immune suppression [AMIS]) was a landmark clinical development.
Arijita Jash +6 more
doaj +2 more sources
Type I interferon signature strength correlates with alloimmunization-associated transcriptomic programs in systemic lupus erythematosus: A multi-cohort analysis. [PDF]
PLoS ONERed blood cell (RBC) alloimmunization is a clinically significant complication in transfused patients whose immunological determinants remain incompletely understood.
Jaeeun Yoo
doaj +2 more sources
Alloantigen Copy Number as a Critical Factor in RBC Alloimmunization [PDF]
Transfusion Medicine Reviews, 2023 James C Zimring +2 more
exaly +2 more sources
Impact of Rh five-antigen–matched transfusion on alloimmunization and clinical outcomes in patients requiring repeated red blood cell transfusions: a prospective randomized controlled study [PDF]
Frontiers in MedicineBackgroundRed blood cell (RBC) alloimmunization remains a significant challenge in patients requiring repeated transfusions, complicating transfusion procedures and increasing healthcare resource utilization.
Xiaolu Xie +3 more
doaj +2 more sources
Erythrocyte Alloimmunization and Transfusion Strategies in Sickle Cell Disease: A Single-Center Analysis [PDF]
Journal of Blood MedicineAbdulaziz Yusuf,1,2 Abrar Ahmad,1 Hesham A El-Beshbishy,3 Heba Badie Gong,3 Chahed Walid Chahdah,3 Tahani Bakhsh4 1Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; 2Blood Bank Department, Dr. Soliman Fakeeh
Yusuf A +5 more
doaj +2 more sources
Reticulocytes in donor blood units enhance red blood cell alloimmunization
Haematologica, 2023 Although red blood cell (RBC) transfusions save lives, some patients develop clinically-significant alloantibodies against donor blood group antigens, which then have adverse effects in multiple clinical settings. Few effective measures exist to prevent
Tiffany A. Thomas +12 more
doaj +1 more source