Results 31 to 40 of about 39,925 (149)

Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion

Frontiers in Immunology, 2018
Red blood cell (RBC) alloimmunization represents a significant immunological challenge for some patients. While a variety of immune constituents likely contribute to the initiation and orchestration of alloantibodies to RBC antigens, identification of ...
Seema R. Patel, David R. Gibb, Kathryn Girard-Pierce, Xiaoxi Zhou, Lilian Cataldi Rodrigues, Connie M. Arthur, Ashley L. Bennett, Ryan P. Jajosky, Megan Fuller, Cheryl L. Maier, Patricia E. Zerra, Satheesh Chonat, Nicole H. Smith, Christopher A. Tormey, Jeanne E. Hendrickson, Sean R. Stowell   +15 more
doaj   +1 more source

Analysis of red blood cell alloimmunization among inpatients: 104 588 cases

Zhongguo shuxue zazhi, 2023
Objective To analyze the yield, specificity and detection time of red blood cell(RBC)alloimmunization in 104 588 inpatients. Methods The clinical information of patients who underwent at least one antibody screening in our hospital from November 2017 to ...
Shuling DONG, Jie SONG, Shuya WANG, Qiankun YANG, Xianping LYU   +4 more
doaj   +1 more source

Study of alloimmunization and autoimmunization in Iranian β-thalassemia major patients

Asian Journal of Transfusion Science, 2016
Background: Thalassemia is one of the most common monogenic disorders characterized by reduced production of globin chains. Although regular red blood cell (RBC) transfusion support is the main treatment for these patients, it may be associated with ...
Kambiz Davari, Mohammad Soleiman Soltanpour   +1 more
doaj   +1 more source

Anti‐Erythrocyte Antibody Formation in Individuals With and Without Known Sensitisation Pathways Reflecting Indications for Extended Immunohaematology Screening

Journal of Clinical Laboratory Analysis, EarlyView.
– The yearly incidence of anti‐red blood cell antibodies stratified by participant groups and temporal evolution. – Overall significance p = 3.756 × 10−29. ABSTRACT Background Blood transfusion therapies are of vital importance for many patient groups.
Milanka Milosavić, Marko Lilić, Gordana Guzijan, Dušan Vučetić   +3 more
wiley   +1 more source

Analysis of red cell alloimmunization in multi transfused patients at a Tertiary care teaching hospital

Journal of Family Medicine and Primary Care, 2020
Background: Red blood cell (RBC) alloimmunization is an immune response against foreign RBC antigens; this generally occurs after sensitization due to multiple blood transfusions and pregnancies.
Anjali Handa, Neetu Kukar, Ram N Maharishi, Neha Syal, Harkiran Arora   +4 more
doaj   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Alloimmunization is associated with older age of transfused red blood cells in sickle cell disease [PDF]

, 2015
Red blood cell (RBC) alloimmunization is a significant clinical complication of sickle cell disease (SCD). It can lead to difficulty with cross-matching for future transfusions and may sometimes trigger life-threatening delayed hemolytic transfusion ...
Park, Yara A., Payal C. Desai, Bahjat Qaqish, Emily R. Pfaff, Desai, Payal C., Deal, Allison M., Leyna M. Hebden, Qaqish, Bahjat, Hebden, Leyna M., Kenneth I. Ataga, Pfaff, Emily R., Allison M. Deal, Yara A. Park, Ataga, Kenneth I.   +13 more
core   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source

Incidence and frequency of various red blood cell antibodies and the experience of providing antigen-negative transfusion support for patients at a tertiary care super specialty hospital

Global Journal of Transfusion Medicine, 2019
Introduction: The presence of red blood cell (RBC) auto and/or alloantibodies can pose a serious challenge of finding transfusion support for such patients.
Ruhi Mehra, Minal Rane, Ujwala D'Mello, Rajesh B Sawant   +3 more
doaj   +1 more source