Results 21 to 30 of about 3,855 (116)

Management challenge of a rare concomitant platelet glycoprotein IV/CD36 and IIb/IIIa deficiencies: Case illustration

Transfusion, Volume 65, Issue 4, Page 767-772, April 2025.
Abstract Introduction/Background Platelet membrane glycoproteins (GPs) serve several functions, the most significant of which is their role in primary hemostasis. Among these, GP IIb/IIIa is the primary fibrinogen receptor and is essential for platelet aggregation.
Tro Sekayan, Elizabeth S. Allen, Patricia Kopko, Laura D. Stephens, Mitchell Zhao, Brian R. Curtis, Mia J. Sullivan, Valerie Trapp‐Stamborski, Annette von Drygalski   +8 more
wiley   +1 more source

Differences in the product characteristics and clinical use of granulocytes for transfusion: The BEST Collaborative study

Transfusion, EarlyView.
Abstract Background Whether granulocytes for transfusion are beneficial remains uncertain, although some evidence suggests that efficacy may be dose‐related. Granulocytes are mostly produced by apheresis procedure, but other means of production are increasingly used.
Lorna Cain, Charles Lafrance, Suzy Morton, Catherine Latour, Mélissa Girard, Pierre Tiberghien, Virginie de la Taille, Suvro Sankha Datta, Mrigender Singh Virk, Jennifer Andrews, Vered Yahalom, Ana María Pugliese, Romina Alba, Richard Charlewood, Susy Kirwan, Ana Paula Hitomi Yokoyama, Jose Mauro Kutner, Eva Alonso Nogues, Nuria Martinez i Llonch, James Daly, David O. Irving, Torsten J. Schulze, Elise Huisman, Kaatje Le Poole, Hans Vrielink, Nabiha H. Saifee, Monica B. Pagano, Simon Stanworth, The Biomedical Excellence for Safer Transfusion Collaborative   +28 more
wiley   +1 more source

Comparison of conventional tube technique with automated gel microcolumn assay for antenatal antibody monitoring

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Timely identification of pregnancies at risk of severe haemolytic disease of the fetus and newborn (HDFN) requires accurate and reproducible antibody titration. This study aimed to establish a critical titre for the gel microcolumn assay (GMA) corresponding to the critical titre of ≥16 for the conventional tube ...
Kati Sulin, Mikko Arvas, Suvi Toivonen, Katri Haimila, Jaana Mättö, Inna Sareneva, Riina Jernman, Anna Parhamaa, Susanna Sainio   +8 more
wiley   +1 more source

Breaking down barriers: Recruiting donors of African ancestry in Ireland

Vox Sanguinis, EarlyView.
Abstract Background and Objectives The diversity of the donor pool has an impact on blood provision for patients with inherited blood disorders, such as sickle cell anaemia. Many patients are critically dependent on red cell transfusions and due to uneven antigen distribution among different ethnic groups, they are at high risk of red cell ...
Allison Waters, Niamh O'Flaherty, Ellen McSweeney, Safa Eltom, Barry Egan, Tor Hervig   +5 more
wiley   +1 more source

Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice

The Journal of Physiology, EarlyView.
Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida, Meghann L. Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M. N. Quezado   +4 more
wiley   +1 more source

Neonatal alloimmune thrombocytopenia

BMJ, 2003
Neonatal alloimmune thrombocytopenia—caused by movement of maternal alloantibodies directed against fetal platelet antigens across the placenta—is the most common cause of severe neonatal thrombocytopenia.1 These alloantibodies cause thrombocytopenia, which may result in intracranial haemorrhage.2 3 Most cases arise unexpectedly, and prompt diagnosis ...
H Yarranton, David L. Allen, J Birchall, R Rayment, J Hewertson, Michael F. Murphy, David J. Roberts   +6 more
openaire   +4 more sources

Impact of Voxelotor on Red Blood Cell Exchange Therapeutic Procedures: Evaluation of Multi‐Institutional Procedure Data

Journal of Clinical Apheresis, Volume 40, Issue 3, June 2025.
ABSTRACT Hemoglobin S (HbS) polymerization inhibitor drugs such as voxelotor can result in a split peak in HbS as well as additional peaks with hemoglobin A in quantitative methods of HbS measurement. It is unclear how these results should be used to make transfusion decisions.
Sally Campbell‐Lee, Ming Jin, Lisandro Fortuny, Daniel Sop, Suzanne Thibodeaux, Susan D‐Roseff   +5 more
wiley   +1 more source

Grand Challenges in Alloimmunity and Transplantation [PDF]

Frontiers in Immunology, 2011
The pioneering Times Although the concept of Transplantation could be traced back as early as Saint Cosmas and Damian most famous miracle, grafting of a leg to replace a patient’s ulcered leg, it is not before the 50’s that it entered reality.
openaire   +4 more sources

Hermansky‐Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies

IUBMB Life, Volume 77, Issue 5, May 2025.
ABSTRACT Hermansky‐Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome‐related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous albinism, bleeding tendency, and, in some cases, pulmonary fibrosis, granulomatous colitis, and ...
Francesca Tondi, Roberta Annamaria Cirsmaru, Chiara Conti, Antonia Follenzi, Paolo Gresele, Cristina Olgasi, Loredana Bury   +6 more
wiley   +1 more source

Comparison of intrauterine transfusion techniques in hemolytic disease of the fetus and newborn

Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 5, Page 589-596, May 2025.
ABSTRACT Objectives Intrauterine transfusions (IUTs) are the cornerstone in treatment for hemolytic disease of the fetus and newborn (HDFN). It has been suggested that a non‐vascular intraperitoneal blood transfusion used in conjunction with an intravascular IUT can slow the decrease in fetal hemoglobin (Hb) levels, potentially extending the interval ...
R. M. van 't Oever, V. M. van Duijn, F. Slaghekke, M. C. Haak, D. P. de Winter, E. Lopriore, M. de Haas, S. Le Cessie, E. J. T. Verweij   +8 more
wiley   +1 more source